Hepat Mon. 2015 Apr 25;15(5):e23618. doi: 10.5812/hepatmon.15(04)2015.23618. eCollection 2015 May.
Prevalence of National Responsiveness to HBV Vaccine After 22 Years of Iranian Expanded Program on Immunization (EPI): A Systematic Review and Meta-Analysis Study.
Hepatitis monthly
Reza Rezaee, Bahman Aghcheli, Vahdat Poortahmasebi, Mostafa Qorbani, Seyed Moayed Alavian, Seyed Mohammad Jazayeri
Affiliations
Affiliations
- Ministry of Health and Medical Education, Deputy of Curative Affairs, Budget Administration, Tehran, IR Iran.
- Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran.
- Department of Community Medicine, Alborz University of Medical Sciences, Karaj, IR Iran ; Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Iran.
- Middle East Liver Diseases Center (MELD Center), Tehran, IR Iran.
PMID: 26045701
PMCID: PMC4451270 DOI: 10.5812/hepatmon.15(04)2015.23618
Abstract
CONTEXT: Hepatitis B Virus expanded program on immunization (EPI) started on 1993 in Iran. Most surveys have assessed the level of response to vaccine by measuring the titers of anti-HBs. This meta- analysis aimed to summarize the Iranian published data on the rate of vaccine-responders versus non-responders. Moreover, the impact of variables such as age, gender, type of vaccine, etc. on the levels of responsiveness was evaluated.
EVIDENCE ACQUISITION: All published papers on this topic in Iranian and international journals with affiliation of "Iran" were reviewed using standard keywords up to 2014. We included our study to healthy participants with no previous HBV infection and who had already received a complete course of HB vaccine. The estimated prevalence and 95% confidence intervals in 28 eligible articles for HBV vaccine responders (anti-HBs > 10 IU/mL) and non-responders (10 <) were analyzed by random effect method due to between-study heterogeneity.
RESULTS: The age of subjects was between 6 months and 15 years old. Overall, 5991 (51.5%) were male and 4571 (48.5%) females. Overall, 80% were responders to vaccine versus 20% nonresponders. With increase in age, the number of responders to vaccine decreased significantly (P = 0.001). There was no strong difference between responders versus nonresponders to vaccine for gender, types of vaccine, ethnicity and living area.
CONCLUSIONS: The results arose from this meta-analysis highlighted the safety of vaccine and its effectiveness in stimulating immune response of vaccines, despite being different in generation, manufacturers and types. Moreover, there was no substantial difference between Iranian and other international investigations in the rate of nonresponsiveness to HBV vaccine.
Keywords: Anti-HBs; Expanded Program on Vaccination; HBV Vaccine; Nonresponder; Responder
References
- J Med Virol. 2014 Oct;86(10):1700-4 - PubMed
- Infection. 1989 Mar-Apr;17(2):70-6 - PubMed
- Indian Pediatr. 2004 Dec;41(12):1232-7 - PubMed
- Hepat Mon. 2010 Winter;10(1):17-21 - PubMed
- J Med Virol. 2009 Sep;81(9):1517-24 - PubMed
- Lancet. 2000 Feb 12;355(9203):561-5 - PubMed
- Int J Infect Dis. 2008 Mar;12(2):183-9 - PubMed
- Eur J Pediatr. 2012 Dec;171(12):1761-6 - PubMed
- J Pediatr (Rio J). 2004 Mar-Apr;80(2):113-8 - PubMed
- J Epidemiol Community Health. 2007 Jul;61(7):578-84 - PubMed
- Panminerva Med. 2010 Sep;52(3):177-82 - PubMed
- J Infect Dis. 2009 Jul 1;200(1):39-47 - PubMed
- East Mediterr Health J. 2013 Dec;19(12):990-4 - PubMed
- J Hepatol. 2009 Feb;50(2):426-31 - PubMed
- Acta Paediatr. 1998 Mar;87(3):336-8 - PubMed
- Vaccine. 2001 Aug 14;19(31):4544-8 - PubMed
- Vaccine. 1999 Jun 4;17(20-21):2661-6 - PubMed
- Saudi Med J. 2005 Feb;26(2):281-4 - PubMed
- Vaccine. 2013 Dec 17;32(1):62-8 - PubMed
- Trop Med Int Health. 2006 Oct;11(10):1496-502 - PubMed
- Rev Soc Bras Med Trop. 2011 Jul-Aug;44(4):412-5 - PubMed
- Ann Intern Med. 2005 Mar 1;142(5):333-41 - PubMed
- Med Princ Pract. 2007;16(4):306-9 - PubMed
- J Ayub Med Coll Abbottabad. 2006 Oct-Dec;18(4):4-9 - PubMed
- PLoS One. 2014 May 05;9(5):e95307 - PubMed
- Autoimmun Rev. 2003 Sep;2(5):248-57 - PubMed
- J Prev Med Hyg. 2014 Mar;55(1):1-3 - PubMed
- Lancet. 2005 Oct 15-21;366(9494):1379-84 - PubMed
- Hum Vaccin Immunother. 2013 Jul;9(7):1466-76 - PubMed
- J Gastrointestin Liver Dis. 2007 Dec;16(4):403-6 - PubMed
- Infection. 2009 Jun;37(3):266-9 - PubMed
- J Med Virol. 1996 Dec;50(4):283-8 - PubMed
- Vaccine. 2007 Apr 30;25(17):3511-4 - PubMed
- Vaccine. 1983 Dec;1(1):10-2 - PubMed
- East Mediterr Health J. 2008 Jul-Aug;14(4):960-5 - PubMed
Publication Types