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Berger JL, Samrao D, Huang M, et al. Primary gynecologic melanoma: A report of two unusual cases. Gynecol Oncol Rep. 2015;11:31-3doi: 10.1016/j.gore.2015.01.003.
Berger, J. L., Samrao, D., Huang, M., & Olawaiye, A. B. (2015). Primary gynecologic melanoma: A report of two unusual cases. Gynecologic oncology reports, 1131-3. https://doi.org/10.1016/j.gore.2015.01.003
Berger, Jessica L, et al. "Primary gynecologic melanoma: A report of two unusual cases." Gynecologic oncology reports vol. 11 (2015): 31-3. doi: https://doi.org/10.1016/j.gore.2015.01.003
Berger JL, Samrao D, Huang M, Olawaiye AB. Primary gynecologic melanoma: A report of two unusual cases. Gynecol Oncol Rep. 2015 Jan 17;11:31-3. doi: 10.1016/j.gore.2015.01.003. eCollection 2015 Jan. PMID: 26076092; PMCID: PMC4434166.
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Gynecol Oncol Rep. 2015 Jan 17;11:31-3. doi: 10.1016/j.gore.2015.01.003. eCollection 2015 Jan.

Primary gynecologic melanoma: A report of two unusual cases.

Gynecologic oncology reports

Jessica L Berger, Daman Samrao, Marilyn Huang, Alexander B Olawaiye

Affiliations

  1. Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
  2. Department of Pathology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

PMID: 26076092 PMCID: PMC4434166 DOI: 10.1016/j.gore.2015.01.003

Abstract

BACKGROUND: Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically.

CASES: A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab.

CONCLUSION: Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.

Keywords: Cervical melanoma; Immunotherapy; Multidisciplinary treatment; Ovarian melanoma

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