Display options
Cite
Torres ER, Strack EF, Fernandez CE, et al. Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Prev Med Rep. 2015;2:319-325doi: 10.1016/j.pmedr.2015.04.013.
Torres, E. R., Strack, E. F., Fernandez, C. E., Tumey, T. A., & Hitchcock, M. E. (2015). Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Preventive medicine reports, 2319-325. https://doi.org/10.1016/j.pmedr.2015.04.013
Torres, Elisa R, et al. "Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies." Preventive medicine reports vol. 2 (2015): 319-325. doi: https://doi.org/10.1016/j.pmedr.2015.04.013
Torres ER, Strack EF, Fernandez CE, Tumey TA, Hitchcock ME. Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies. Prev Med Rep. 2015;2:319-325. doi: 10.1016/j.pmedr.2015.04.013. PMID: 26046015; PMCID: PMC4450803.
Copy Download .nbib Format: NLM
Share it on

Prev Med Rep. 2015;2:319-325. doi: 10.1016/j.pmedr.2015.04.013.

Physical Activity and White Matter Hyperintensities: A Systematic Review of Quantitative Studies.

Preventive medicine reports

Elisa R Torres, Emily F Strack, Claire E Fernandez, Tyler A Tumey, Mary E Hitchcock

Affiliations

  1. School of Nursing, 4123 Signe Skott Cooper Hall, 701 Highland Avenue, University of Wisconsin, Madison, WI 53705, 1 (608) 263-5268 Phone, 1 (608) 263-5323 Fax.
  2. College of Letters and Science, 1305 Linden Drive, University of Wisconsin, Madison, WI 53706.
  3. Department of Health Sciences Library, School of Medicine and Public Health, 2339 Health Sciences Learning Center, 750 Highland Avenue, Madison, WI 53705.

PMID: 26046015 PMCID: PMC4450803 DOI: 10.1016/j.pmedr.2015.04.013

Abstract

OBJECTIVE: White matter hyperintensities (WMH) are markers of brain white matter injury seen on magnetic resonance imaging. WMH increase with age and are associated with neuropsychiatric disorders. WMH progression can be slowed by controlling vascular risk factors in individuals with advanced disease. Since physical activity can decrease vascular risk factors, physical activity may slow the progression of WMH in individuals without advanced disease, thereby preventing neuropsychiatric disorders. The purpose of this systematic review was to examine the association between physical activity and WMH in individuals without advanced disease.

METHODS: Articles published in English through March 18, 2014 were searched using PubMed, Web of Science, Cochrane Library and EBSCOhost.

RESULTS: Six studies found that more physical activity was associated with less WMH, while 6 found no association. Physical activity is associated with less WMH in individuals without advanced disease when studies are longitudinal or take into consideration physical activity across the lifespan, have a younger sample of older adults, measure different types of physical activity beyond leisure or objectively measure fitness via V0

CONCLUSION: More physical activity was associated with less white matter hyperintensities in individuals without advanced disease.

Keywords: exercise; leukoaraiosis; magnetic resonance imaging

References

  1. J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):619-24 - PubMed
  2. Gerontology. 2012;58(5):398-406 - PubMed
  3. AJNR Am J Neuroradiol. 2009 Nov;30(10):1857-63 - PubMed
  4. Neurology. 1995 Nov;45(11):2077-84 - PubMed
  5. Stroke. 2010 Mar;41(3):554-6 - PubMed
  6. Public Health Rep. 1985 Mar-Apr;100(2):126-31 - PubMed
  7. BMC Med Genomics. 2009 Apr 07;2:16 - PubMed
  8. Neurology. 1999 Apr 12;52(6):1119-24 - PubMed
  9. Med Sci Sports Exerc. 2007 Aug;39(8):1435-45 - PubMed
  10. Circulation. 2005 Sep 13;112(11):1644-50 - PubMed
  11. Neuroimage. 2013 Nov 15;82:510-6 - PubMed
  12. PLoS One. 2013 Jul 05;8(7):e66844 - PubMed
  13. Sports Med. 2010 Jul 1;40(7):565-600 - PubMed
  14. JAMA. 2000 Apr 19;283(15):2008-12 - PubMed
  15. Br J Sports Med. 2003 Jun;37(3):197-206; discussion 206 - PubMed
  16. PLoS Med. 2009 Jul 21;6(7):e1000100 - PubMed
  17. Biol Psychiatry. 2008 Aug 15;64(4):273-80 - PubMed
  18. Hum Brain Mapp. 2011 Sep;32(9):1371-82 - PubMed
  19. Neurology. 2012 Oct 23;79(17):1802-8 - PubMed
  20. Neurotherapeutics. 2007 Jul;4(3):316-29 - PubMed
  21. Neurobiol Aging. 2004 Jan;25(1):3-4 - PubMed
  22. J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):639-47 - PubMed
  23. J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):848-54 - PubMed
  24. Neurology. 2007 Apr 10;68(15):1223-6 - PubMed
  25. Stroke. 2010 Apr;41(4):600-6 - PubMed
  26. Neurology. 2011 Jun 14;76(24):2112-8 - PubMed
  27. Neurodegener Dis. 2012;10(1-4):135-7 - PubMed
  28. Neurobiol Aging. 2010 Nov;31(11):1927-36 - PubMed
  29. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70 - PubMed

Publication Types

Grant support