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Moysés-Neto M, Costa RS, Rodrigues FF, et al. Minimal change disease: a variant of lupus nephritis. NDT Plus. 2010;4(1):20-2doi: 10.1093/ndtplus/sfq179.
Moysés-Neto, M., Costa, R. S., Rodrigues, F. F., Vieira Neto, O. M., Reis, M. A., Louzada Júnior, P., Romão, E. A., & Dantas, M. (2011). Minimal change disease: a variant of lupus nephritis. NDT plus, 4(1), 20-2. https://doi.org/10.1093/ndtplus/sfq179
Moysés-Neto, Miguel, et al. "Minimal change disease: a variant of lupus nephritis." NDT plus vol. 4,1 (2011): 20-2. doi: https://doi.org/10.1093/ndtplus/sfq179
Moysés-Neto M, Costa RS, Rodrigues FF, Vieira Neto OM, Reis MA, Louzada Júnior P, Romão EA, Dantas M. Minimal change disease: a variant of lupus nephritis. NDT Plus. 2011 Feb;4(1):20-2. doi: 10.1093/ndtplus/sfq179. Epub 2010 Oct 22. PMID: 25984093; PMCID: PMC4421630.
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NDT Plus. 2011 Feb;4(1):20-2. doi: 10.1093/ndtplus/sfq179. Epub 2010 Oct 22.

Minimal change disease: a variant of lupus nephritis.

NDT plus

Miguel Moysés-Neto, Roberto S Costa, Fernanda F Rodrigues, Osvaldo M Vieira Neto, Marlene A Reis, Paulo Louzada Júnior, Elen A Romão, Márcio Dantas

Affiliations

  1. Faculty of Medicine of Ribeirão Preto , University of São Paulo , Ribeirão Preto, SP , Brazil.
  2. Faculty of Medicine of Triângulo Mineiro , Federal University of Triângulo Mineiro , Uberaba, MG , Brazil.

PMID: 25984093 PMCID: PMC4421630 DOI: 10.1093/ndtplus/sfq179

Abstract

Some patients with systemic lupus erythematosus (SLE) present with nephrotic syndrome due to minimal change disease (MCD). Histopathological diagnosis of patients with SLE and nephrotic-range proteinuria has shown that these patients present with diffuse proliferative glomerulonephritis and membranous glomerulonephritis, World Health Organization (WHO) classes IV and V, respectively, more frequently than the other classes. In the present study, we reported a case of nephrotic syndrome and renal biopsy-proven MCD associated with SLE. A complete remission occurred after steroid treatment, which was followed by a relapse 15 months later with a concomitant reactivation of SLE. A second biopsy showed WHO class IIb lupus nephritis. Prednisone treatment was restarted, and the patient went into complete remission again. The association of MCD and SLE may not be a coincidence, and MCD should be considered as an associated SLE nephropathy.

Keywords: lupus nephritis; minimal change disease; prednisone

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