Display options
Cite
Federzoni EA, Gloor S, Jin J, et al. Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leuk Res Rep. 2015;4(1):32-5doi: 10.1016/j.lrr.2015.04.002.
Federzoni, E. A., Gloor, S., Jin, J., Shan-Krauer, D., Fey, M. F., Torbett, B. E., & Tschan, M. P. (2015). Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leukemia research reports, 4(1), 32-5. https://doi.org/10.1016/j.lrr.2015.04.002
Federzoni, Elena A, et al. "Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells." Leukemia research reports vol. 4,1 (2015): 32-5. doi: https://doi.org/10.1016/j.lrr.2015.04.002
Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP. Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leuk Res Rep. 2015 Apr 23;4(1):32-5. doi: 10.1016/j.lrr.2015.04.002. eCollection 2015. PMID: 25984443; PMCID: PMC4431638.
Copy Download .nbib Format: NLM
Share it on

Leuk Res Rep. 2015 Apr 23;4(1):32-5. doi: 10.1016/j.lrr.2015.04.002. eCollection 2015.

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.

Leukemia research reports

Elena A Federzoni, Severin Gloor, Jing Jin, Deborah Shan-Krauer, Martin F Fey, Bruce E Torbett, Mario P Tschan

Affiliations

  1. Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.
  2. Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland.
  3. Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
  4. Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
  5. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.

PMID: 25984443 PMCID: PMC4431638 DOI: 10.1016/j.lrr.2015.04.002

Abstract

In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differentiation cell models showed increased SENP5 expression upon induction of differentiation; in contrast, knocking down SENP5 resulted in significantly attenuated neutrophil differentiation. Our results support a new role of SENP5 in AML pathology, and in particular in the neutrophil differentiation of myeloid leukemic cells.

Keywords: AML; Acute myeloid leukemia; Neutrophil differentiation; SENP5; SUMO protease

References

  1. Trends Biochem Sci. 2007 Jun;32(6):286-95 - PubMed
  2. J Biol Chem. 2006 Jun 9;281(23):15869-77 - PubMed
  3. Nat Rev Cancer. 2010 Nov;10(11):775-83 - PubMed
  4. Nat Med. 2008 Dec;14(12):1333-42 - PubMed
  5. Cancer. 2006 Nov 1;107(9):2099-107 - PubMed
  6. Cell Rep. 2014 Jun 26;7(6):1815-23 - PubMed
  7. Nat Cell Biol. 2008 May;10 (5):538-46 - PubMed
  8. Nat Cell Biol. 2008 May;10 (5):547-55 - PubMed
  9. Blood. 2012 May 24;119(21):4963-70 - PubMed
  10. J Leukoc Biol. 2007 Jun;81(6):1599-608 - PubMed

Publication Types