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Poloni S, Blom HJ, Schwartz IV. Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?. Biology (Basel). 2015;4(2):383-96doi: 10.3390/biology4020383.
Poloni, S., Blom, H. J., & Schwartz, I. V. (2015). Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?. Biology, 4(2), 383-96. https://doi.org/10.3390/biology4020383
Poloni, Soraia, et al. "Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?." Biology vol. 4,2 (2015): 383-96. doi: https://doi.org/10.3390/biology4020383
Poloni S, Blom HJ, Schwartz IV. Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?. Biology (Basel). 2015 Jun 03;4(2):383-96. doi: 10.3390/biology4020383. PMID: 26046927; PMCID: PMC4498306.
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Biology (Basel). 2015 Jun 03;4(2):383-96. doi: 10.3390/biology4020383.

Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?.

Biology

Soraia Poloni, Henk J Blom, Ida V D Schwartz

Affiliations

  1. Post-Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500 Prédio 43323M, Porto Alegre, RS 91501-970, Brazil. [email protected].
  2. Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Adolescent Medicine and Neonatology, University Medical Centre Freiburg, Mathildenstrasse 1, Freiburg 79106, Germany. [email protected].
  3. Post-Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500 Prédio 43323M, Porto Alegre, RS 91501-970, Brazil. [email protected].
  4. Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 Santa Cecília, Porto Alegre, RS 90035-903, Brazil. [email protected].

PMID: 26046927 PMCID: PMC4498306 DOI: 10.3390/biology4020383

Abstract

An association between sulfur amino acids (methionine, cysteine, homocysteine and taurine) and lipid metabolism has been described in several experimental and population-based studies. Changes in the metabolism of these amino acids influence serum lipoprotein concentrations, although the underlying mechanisms are still poorly understood. However, recent evidence has suggested that the enzyme stearoyl-CoA desaturase-1 (SCD-1) may be the link between these two metabolic pathways. SCD-1 is a key enzyme for the synthesis of monounsaturated fatty acids. Its main substrates C16:0 and C18:0 and products palmitoleic acid (C16:1) and oleic acid (C18:1) are the most abundant fatty acids in triglycerides, cholesterol esters and membrane phospholipids. A significant suppression of SCD-1 has been observed in several animal models with disrupted sulfur amino acid metabolism, and the activity of SCD-1 is also associated with the levels of these amino acids in humans. This enzyme also appears to be involved in the etiology of metabolic syndromes because its suppression results in decreased fat deposits (regardless of food intake), improved insulin sensitivity and higher basal energy expenditure. Interestingly, this anti-obesogenic phenotype has also been described in humans and animals with sulfur amino acid disorders, which is consistent with the hypothesis that SCD-1 activity is influenced by these amino acids, in particularly cysteine, which is a strong and independent predictor of SCD-1 activity and fat storage. In this narrative review, we discuss the evidence linking sulfur amino acids, SCD-1 and lipid metabolism.

Keywords: SCD-1; cysteine; homocysteine; homocystinuria; lipoproteins; stearoyl CoA desaturase-1; sulfur amino acids

References

  1. Adv Exp Med Biol. 2013;776:129-39 - PubMed
  2. Metabolism. 2013 Apr;62(4):509-17 - PubMed
  3. J Nutr. 2006 Jun;136(6 Suppl):1726S-1730S - PubMed
  4. Hum Mol Genet. 2001 Mar 1;10(5):433-43 - PubMed
  5. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1585-9 - PubMed
  6. Lipids Health Dis. 2013 Mar 13;12:34 - PubMed
  7. Can Fam Physician. 2000 Nov;46:2236-45 - PubMed
  8. Prostaglandins Leukot Essent Fatty Acids. 2013 Oct;89(5):297-303 - PubMed
  9. J Cell Biochem. 2013 Oct;114(10):2334-45 - PubMed
  10. J Biol Chem. 2011 Oct 21;286(42):36258-67 - PubMed
  11. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11482-6 - PubMed
  12. J Nutr Biochem. 2012 Apr;23(4):332-40 - PubMed
  13. Br J Nutr. 2013 Sep 14;110(5):871-9 - PubMed
  14. Atherosclerosis. 2010 Sep;212(1):268-73 - PubMed
  15. Ann Saudi Med. 2005 May-Jun;25(3):209-14 - PubMed
  16. Mol Nutr Food Res. 2012 Jun;56(6):900-11 - PubMed
  17. Obesity (Silver Spring). 2009 Jul;17(7):1435-40 - PubMed
  18. Mol Nutr Food Res. 2012 May;56(5):681-90 - PubMed
  19. FEBS Lett. 2009 Apr 17;583(8):1215-25 - PubMed
  20. Circ Res. 2006 Sep 15;99(6):598-606 - PubMed
  21. J Inherit Metab Dis. 2011 Feb;34(1):75-81 - PubMed
  22. Am J Clin Nutr. 2014 Jan;99(1):79-85 - PubMed
  23. J Biol Chem. 2004 Dec 17;279(51):52961-9 - PubMed
  24. Obesity (Silver Spring). 2013 Mar;21(3):E294-302 - PubMed
  25. J Bone Joint Surg Br. 1972 May;54(2):277-98 - PubMed
  26. J Biol Chem. 2002 Dec 20;277(51):49446-52 - PubMed
  27. Acta Biochim Biophys Sin (Shanghai). 2007 Jan;39(1):19-26 - PubMed
  28. Exp Mol Med. 2012 Nov 30;44(11):665-73 - PubMed
  29. Biomark Med. 2014;8(3):405-12 - PubMed
  30. Diabetologia. 2005 Oct;48(10):1999-2005 - PubMed
  31. Gene. 2014 Aug 10;546(2):443-7 - PubMed
  32. Nutrition. 2010 Nov-Dec;26(11-12):1201-4 - PubMed
  33. Ann Nutr Metab. 2008;52(3):196-203 - PubMed
  34. Am J Clin Nutr. 2008 Sep;88(3):738-46 - PubMed
  35. Nutr Metab Cardiovasc Dis. 2012 Dec;22(12):1031-8 - PubMed
  36. Mol Biol Rep. 2012 Mar;39(3):3001-7 - PubMed
  37. Mol Biol Cell. 1997 Nov;8(11):2281-90 - PubMed
  38. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E28-37 - PubMed
  39. J Nutr. 2006 Jun;136(6 Suppl):1666S-1669S - PubMed
  40. CMAJ. 2000 Jul 11;163(1):21-9 - PubMed
  41. J Nutr. 2006 Jun;136(6 Suppl):1636S-1640S - PubMed
  42. J Lipid Res. 2012 Aug;53(8):1646-53 - PubMed
  43. PLoS One. 2011;6(11):e27598 - PubMed
  44. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48 - PubMed
  45. J Lipid Res. 2001 Jul;42(7):1018-24 - PubMed
  46. FASEB J. 2005 Apr;19(6):599-601 - PubMed
  47. J Inherit Metab Dis. 2006 Feb;29(1):3-20 - PubMed
  48. J Nutr. 2004 Sep;134(9):2455S-2463S - PubMed
  49. Prog Lipid Res. 2013 Jan;52(1):15-42 - PubMed
  50. Nutr Metab Cardiovasc Dis. 2008 Jul;18(6):436-40 - PubMed
  51. Nutr Metab Cardiovasc Dis. 2006 Mar;16(2):128-36 - PubMed
  52. J Clin Invest. 2001 May;107(10):1263-73 - PubMed
  53. Obesity (Silver Spring). 2013 Sep;21(9):E512-9 - PubMed
  54. Mamm Genome. 2014 Oct;25(9-10):455-63 - PubMed
  55. J Inherit Metab Dis. 2011 Feb;34(1):17-32 - PubMed
  56. Cell Metab. 2007 Dec;6(6):484-96 - PubMed
  57. Nutr Rev. 2004 Jun;62(6 Pt 2):S3-12; discussion S13 - PubMed
  58. Br J Nutr. 2006 May;95(5):879-88 - PubMed
  59. J Biol Chem. 2009 Jul 24;284(30):19961-73 - PubMed
  60. Circulation. 2001 May 29;103(21):2544-9 - PubMed
  61. Circ Res. 2006 Mar 3;98 (4):564-71 - PubMed
  62. J Lipid Res. 2006 Oct;47(10):2280-90 - PubMed
  63. Can Fam Physician. 2008 Apr;54(4):536-41 - PubMed
  64. Clin Chem Lab Med. 2013 Mar 1;51(3):467-75 - PubMed
  65. Curr Opin Clin Nutr Metab Care. 2012 Jan;15(1):49-57 - PubMed
  66. J Inherit Metab Dis. 1997 Jun;20(2):270-85 - PubMed
  67. J Biol Chem. 2012 May 11;287(20):16187-98 - PubMed
  68. Diabetes. 2006 Jul;55(7):2032-41 - PubMed
  69. J Inherit Metab Dis. 1999 May;22(3):243-6 - PubMed
  70. J Lipid Res. 2011 Jan;52(1):104-12 - PubMed
  71. Braz J Med Biol Res. 2010 Jan;43(1):1-7 - PubMed
  72. Mol Genet Metab. 2012 Jul;106(3):382-3 - PubMed
  73. Eur J Pediatr. 1998 Apr;157 Suppl 2:S40-4 - PubMed

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