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Cell Mol Bioeng. 2015 Mar 01;8(1):32-50. doi: 10.1007/s12195-015-0377-8.

Substrate Stiffness Affects Human Keratinocyte Colony Formation.

Cellular and molecular bioengineering

Hoda Zarkoob, Sandeep Bodduluri, Sailahari V Ponnaluri, John C Selby, Edward A Sander

Affiliations

  1. Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
  2. Department of Dermatology, University of Iowa, Iowa City, IA, USA.

PMID: 26019727 PMCID: PMC4442095 DOI: 10.1007/s12195-015-0377-8

Abstract

Restoration of epidermal organization and function in response to a variety of pathophysiological insults is critically dependent on coordinated keratinocyte migration, proliferation, and stratification during the process of wound healing. These processes are mediated by the reconfiguration of both cell-cell (desmosomes, adherens junctions) and cell-matrix (focal adhesions, hemidesmosomes) junctions and the cytoskeletal filament networks that they serve to interconnect. In this study, we investigated the role of substrate elasticity (stiffness) on keratinocyte colony formation

References

  1. Burns. 2012 May;38(3):414-20 - PubMed
  2. J Biol Chem. 2006 Nov 17;281(46):35487-98 - PubMed
  3. J Dermatol Sci. 2011 Apr;62(1):1-7 - PubMed
  4. J Cell Sci Suppl. 1987;8:313-26 - PubMed
  5. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10891-6 - PubMed
  6. Exp Cell Res. 2007 May 1;313(8):1575-87 - PubMed
  7. Exp Dermatol. 1995 Jun;4(3):130-7 - PubMed
  8. J Biomech Eng. 2011 Sep;133(9):091011 - PubMed
  9. J Dermatol Surg Oncol. 1988 Jan;14(1):75-8 - PubMed
  10. PLoS One. 2014 Apr 16;9(4):e90976 - PubMed
  11. Nat Mater. 2012 May 27;11(7):642-9 - PubMed
  12. Am J Physiol Cell Physiol. 2002 Mar;282(3):C595-605 - PubMed
  13. Biophys J. 2006 Mar 15;90(6):2213-20 - PubMed
  14. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7 - PubMed
  15. Biorheology. 2009;46(3):191-205 - PubMed
  16. J Mech Behav Biomed Mater. 2013 Dec;28:397-409 - PubMed
  17. Nat Mater. 2014 Oct;13(10):979-87 - PubMed
  18. Mol Biol Cell. 2009 Jun;20(12 ):2954-62 - PubMed
  19. Lancet. 2012 Sep 15;380(9846):977-85 - PubMed
  20. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13661-5 - PubMed
  21. J Invest Dermatol. 2014 Jul;134(7):1862-72 - PubMed
  22. PLoS One. 2009 Jul 24;4(7):e6382 - PubMed
  23. J Mech Behav Biomed Mater. 2012 Jan;5(1):139-48 - PubMed
  24. J Invest Dermatol. 1991 Dec;97(6):985-94 - PubMed
  25. Biophys J. 2008 Dec 15;95(12):6044-51 - PubMed
  26. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5576-80 - PubMed
  27. J Cell Physiol. 2005 Jul;204(1):198-209 - PubMed
  28. J Vis Exp. 2010 Dec 14;(46):null - PubMed
  29. J Cell Biol. 2006 Jan 16;172(2):259-68 - PubMed
  30. J Cell Biol. 2009 Feb 23;184(4):481-90 - PubMed
  31. Nat Mater. 2013 Sep;12(9):856-63 - PubMed
  32. Exp Cell Res. 1994 Sep;214(1):381-8 - PubMed
  33. PLoS Comput Biol. 2014 Jun 05;10(6):e1003631 - PubMed
  34. Biophys J. 2013 Jul 2;105(1):11-20 - PubMed
  35. J Invest Dermatol. 1995 May;104(5):768-74 - PubMed
  36. Science. 1997 Apr 4;276(5309):75-81 - PubMed
  37. Biorheology. 2007;44(5-6):319-48 - PubMed

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