World J Hepatol. 2015 May 28;7(9):1265-71. doi: 10.4254/wjh.v7.i9.1265.

Hepatitis B among Inuit: A review with focus on Greenland Inuit.

World journal of hepatology

Karsten Fleischer Rex, Stig Andersen, Henrik Bygum Krarup

PMID: 26019742 PMCID: PMC4438501 DOI: 10.4254/wjh.v7.i9.1265

Abstract

Hepatitis B virus (HBV) infection is a disease with a highly variable course. Chronic HBV infection may cause end-stage liver disease including cirrhosis and hepatocellular carcinoma, which is the 3(rd) most common cause of cancer related death due to the poor prognosis. The prevalence of HBV infection is low in many countries. Still, it remains important due to the potential consequences of the disease. HBV is endemic in the Arctic with serologic markers of chronic HBV infection in up to 29% of the population in some areas in Greenland. Interestingly, Inuit populations rarely show signs of liver disease despite the fact that around half of all Inuit has been exposed to HBV and around 8% of Inuit are chronically infected with HBV. These findings have been consistent in surveys conducted for more than four decades among Arctic Inuit. We thus review HBV infection in the Arctic with focus on Greenland Inuit and compared with Inuit in Canada, Alaska and Siberia. The aspects described include epidemiology and monitoring of the disease, as well as treatment and the risk of liver cancer.

Keywords: Arctic; Greenland; Hepatitis B; Hepatitis D; Inuit; Liver cancer; Monitoring disease; Prevention

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