Iran J Pediatr. 2014 Dec;24(6):715-22. Epub 2014 Nov 28.

Presepsin (scd14) as a marker of serious bacterial infections in chemotherapy induced severe neutropenia.

Iranian journal of pediatrics

Elham Olad, Iraj Sedighi, Azim Mehrvar, Maryam Tashvighi, Vahid Fallahazad, Amirabbas Hedayatiasl, Hossein Esfahani

PMID: 26019777 PMCID: PMC4442833

Abstract

OBJECTIVE: Timely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children.

METHODS: In addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013. Fifteen episodes had positive bacterial cultures and 18 had fever. The mean sCD14 values were compared in the presence or absence of fever, positive blood culture and other clinical conditions. Also, mean levels compared in different white cell counts and different four combination settings of fever and blood culture.

FINDINGS: It was statistically higher in febrile episodes, in the presence of oral mucositis, indwelling catheter infection, otitis media, and post toxic epidermal necrolysis sepsis and in instances of death within 15 days. Leukocyte count did not affect sCD14 level and in combinations of fever and blood culture, mean sCD14 values were ranked as follow: febrile culture negatives, febrile culture positives, afebrile culture positives and afebrile culture negatives.

CONCLUSION: Although sCD14 was not sensitive in detection of bacteremia, in the absence of clinically detectable source of infection, it was significantly higher in culture positives.

Keywords: Cancer; Infection; Neutropenia; Pediatrics; Soluble CD14

References

1. Eur J Haematol. 2005 Apr;74(4):297-303 - PubMed
2. J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 2:12-4 - PubMed
3. J Infect Chemother. 2012 Dec;18(6):891-7 - PubMed
4. Eur J Med Res. 2001 Aug 27;6(8):351-8 - PubMed
5. Eur J Oral Sci. 2007 Apr;115(2):93-6 - PubMed
6. Clin Chim Acta. 2006 Apr;366(1-2):156-62 - PubMed
7. Pediatr Hematol Oncol. 2009 Sep;26(6):414-25 - PubMed
8. Res Commun Chem Pathol Pharmacol. 1994 Apr;84(1):17-25 - PubMed
9. J Infect Chemother. 2005 Oct;11(5):234-8 - PubMed
10. J Med Virol. 2003 Oct;71(2):188-94 - PubMed
11. J Infect Chemother. 2011 Dec;17 (6):764-9 - PubMed
12. Clin Exp Immunol. 2000 Feb;119(2):376-81 - PubMed
13. J Pediatr Hematol Oncol. 2007 Feb;29(2):107-11 - PubMed
14. Vet Res. 2003 May-Jun;34(3):307-16 - PubMed
15. Dermatology. 1993;186(1):45-9 - PubMed
16. Int J Legal Med. 2013 Jul;127(4):799-808 - PubMed
17. Int J Mol Med. 2002 Oct;10(4):441-9 - PubMed
18. Scand J Infect Dis. 2007;39(6-7):596-603 - PubMed
19. Clin Diagn Lab Immunol. 2002 Mar;9(2):440-5 - PubMed
20. Microbes Infect. 2004 Sep;6(11):990-5 - PubMed
21. Support Care Cancer. 2008 Sep;16(9):1035-40 - PubMed
22. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):699-704 - PubMed
23. Cell. 2011 Nov 11;147(4):868-80 - PubMed
24. Pediatr Res. 2010 Dec;68(6):490-3 - PubMed
25. Protein Expr Purif. 2003 Apr;28(2):310-20 - PubMed
26. Infection. 2008 Oct;36(5):396-407 - PubMed
27. Innate Immun. 2009 Apr;15(2):121-8 - PubMed
28. Eur J Clin Microbiol Infect Dis. 2004 Jul;23 (7):539-44 - PubMed
29. Infect Immun. 1999 Jan;67(1):417-20 - PubMed
30. J Periodontal Res. 2011 Feb;46(1):147-52 - PubMed
31. J Immunol. 2013 Feb 1;190(3):1304-11 - PubMed

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