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Nauczyciel C, Robic S, Dondaine T, et al. The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder. J Mol Psychiatry. 2013;1:17doi: 10.1186/2049-9256-1-17.
Nauczyciel, C., Robic, S., Dondaine, T., Verin, M., Robert, G., Drapier, D., Naudet, F., & Millet, B. (2013). The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder. Journal of molecular psychiatry, 117. https://doi.org/10.1186/2049-9256-1-17
Nauczyciel, Cecilia, et al. "The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder." Journal of molecular psychiatry vol. 1 (2013): 17. doi: https://doi.org/10.1186/2049-9256-1-17
Nauczyciel C, Robic S, Dondaine T, Verin M, Robert G, Drapier D, Naudet F, Millet B. The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder. J Mol Psychiatry. 2013 Oct 23;1:17. doi: 10.1186/2049-9256-1-17. eCollection 2013. PMID: 26019865; PMCID: PMC4445576.
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J Mol Psychiatry. 2013 Oct 23;1:17. doi: 10.1186/2049-9256-1-17. eCollection 2013.

The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder.

Journal of molecular psychiatry

Cecilia Nauczyciel, Suzanne Robic, Thibaut Dondaine, Marc Verin, Gabriel Robert, Dominique Drapier, Florian Naudet, Bruno Millet

Affiliations

  1. Academic Department of Adult Psychiatry, Guillaume Régnier Hospital, EA 4712 35000, Rennes, France.
  2. Lyon Neuroscience Research Center INSERM U1028 - CNRS UMR 5292 Dynamics and Brain Cognition, 69675, Bron, France.
  3. Rennes University Hospital Centre Research Unit EA 4712 Behavior and Basal Ganglia, 35000, Rennes, France.
  4. Academic Department of Adult Psychiatry, Guillaume Régnier Hospital, EA 4712 35000, Rennes, France ; Rennes University Hospital Centre Research Unit EA 4712 Behavior and Basal Ganglia, 35000, Rennes, France.

PMID: 26019865 PMCID: PMC4445576 DOI: 10.1186/2049-9256-1-17

Abstract

OBJECTIVE: This review aimed to investigate the therapeutic potential of Deep Brain Stimulation (DBS) for treating resistant Major Depressive Disorder (MDD). We explored the role of Nucleus accumbens (Nac) as a target for treatment.

METHOD: We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD.

RESULTS: As a central relay-structure, the Nac seems to play a central role in MDD symptomatology. We investigated its role as a primary target for DBS in depressed patients. Anatomically the Nac is at the centre of the interactions between dopaminergic, serotoninergic and glutamatergic systems. Functionally, the Nac is involved in both normal and abnormal reward processes and in anhedonia and loss of motivation. Due to its central location between the emotional system, the cognitive system and motor control system, the Nac seems to have a central role in mood and feeling regulation.

CONCLUSION: According to encouraging recent studies, DBS seems to be a promising technique in resistant MDD treatment.

Keywords: Deep brain stimulation; Dopamine; Major depressive disorder; Nucleus accumbens

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