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Eid N, Enani S, Walton G, et al. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci. 2014;3:e46doi: 10.1017/jns.2014.16.
Eid, N., Enani, S., Walton, G., Corona, G., Costabile, A., Gibson, G., Rowland, I., & Spencer, J. P. (2014). The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. Journal of nutritional science, 3e46. https://doi.org/10.1017/jns.2014.16
Eid, Noura, et al. "The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation." Journal of nutritional science vol. 3 (2014): e46. doi: https://doi.org/10.1017/jns.2014.16
Eid N, Enani S, Walton G, Corona G, Costabile A, Gibson G, Rowland I, Spencer JP. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci. 2014 Oct 08;3:e46. doi: 10.1017/jns.2014.16. eCollection 2014. PMID: 26101614; PMCID: PMC4473134.
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J Nutr Sci. 2014 Oct 08;3:e46. doi: 10.1017/jns.2014.16. eCollection 2014.

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation.

Journal of nutritional science

Noura Eid, Sumia Enani, Gemma Walton, Giulia Corona, Adele Costabile, Glenn Gibson, Ian Rowland, Jeremy P E Spencer

Affiliations

  1. Department of Food and Nutritional Sciences , School of Chemistry , Food and Pharmacy , University of Reading , Reading RG6 6AP , UK.

PMID: 26101614 PMCID: PMC4473134 DOI: 10.1017/jns.2014.16

Abstract

The fruit of the date palm (Phoenix dactylifera L.) is a rich source of dietary fibre and polyphenols. We have investigated gut bacterial changes induced by the whole date fruit extract (digested date extract; DDE) and its polyphenol-rich extract (date polyphenol extract; DPE) using faecal, pH-controlled, mixed batch cultures mimicking the distal part of the human large intestine, and utilising an array of microbial group-specific 16S rRNA oligonucleotide probes. Fluorescence microscopic enumeration indicated that there was a significant increase in the growth of bifidobacteria in response to both treatments, whilst whole dates also increased bacteroides at 24 h and the total bacterial counts at later fermentation time points when compared with DPE alone. Bacterial metabolism of whole date fruit led to the production of SCFA, with acetate significantly increasing following bacterial incubation with DDE. In addition, the production of flavonoid aglycones (myricetin, luteolin, quercetin and apigenin) and the anthocyanidin petunidin in less than 1 h was also observed. Lastly, the potential of DDE, DPE and metabolites to inhibit Caco-2 cell growth was investigated, indicating that both were capable of potentially acting as antiproliferative agents in vitro, following a 48 h exposure. This potential to inhibit growth was reduced following fermentation. Together these data suggest that consumption of date fruits may enhance colon health by increasing beneficial bacterial growth and inhibiting the proliferation of colon cancer cells. This is an early suggestion that date intake by humans may aid in the maintenance of bowel health and even the reduction of colorectal cancer development.

Keywords: Colonic cancer inhibition; DDE, digested date extract; DPE, date polyphenol extract; Date palm fruit; Date polyphenols; FISH, fluorescence in situ hybridisation; FOS, fructo-oligosaccharide; Gut ecology; SRB, sulforhodamine B

References

  1. Anaerobe. 2010 Oct;16(5):483-8 - PubMed
  2. Food Chem Toxicol. 2010 Oct;48(10):3008-16 - PubMed
  3. J Nutr. 1995 Jun;125(6):1401-12 - PubMed
  4. Eur J Nutr. 2006 Feb;45(1):7-18 - PubMed
  5. Microbiology. 2010 Nov;156(Pt 11):3224-31 - PubMed
  6. Carcinogenesis. 1998 Feb;19(2):281-5 - PubMed
  7. Appl Environ Microbiol. 2000 Oct;66(10):4523-7 - PubMed
  8. Br J Nutr. 2001 Sep;86(3):341-8 - PubMed
  9. Lancet. 2003 May 3;361(9368):1496-501 - PubMed
  10. J Agric Food Chem. 2009 Aug 12;57(15):6485-501 - PubMed
  11. Br J Nutr. 2010 Nov;104(9):1353-6 - PubMed
  12. Chem Biol Interact. 2010 May 14;185(3):174-81 - PubMed
  13. Crit Rev Food Sci Nutr. 2006;46(2):161-83 - PubMed
  14. FEMS Microbiol Ecol. 2005 Apr 1;52(2):145-52 - PubMed
  15. J Agric Food Chem. 2006 Mar 22;54(6):2405-11 - PubMed
  16. Am J Clin Nutr. 2011 Jan;93(1):62-72 - PubMed
  17. J Agric Food Chem. 2012 Apr 18;60(15):3882-90 - PubMed
  18. Int J Food Microbiol. 2010 Jun 15;140(2-3):175-82 - PubMed
  19. Bioorg Med Chem. 2005 Sep 1;13(17):5195-205 - PubMed
  20. Nutr J. 2012 Jun 01;11:36 - PubMed
  21. Anaerobe. 2010 Aug;16(4):420-5 - PubMed
  22. FEMS Microbiol Ecol. 2013 Mar;83(3):792-805 - PubMed
  23. Biochem Biophys Res Commun. 2007 Oct 26;362(3):606-11 - PubMed
  24. Br J Nutr. 2010 Sep;104(5):701-8 - PubMed
  25. Br J Nutr. 2012 Aug;108(3):471-81 - PubMed
  26. Gut. 2000 Jan;46(1):73-7 - PubMed
  27. Appl Environ Microbiol. 1995 Aug;61(8):3069-75 - PubMed
  28. J Agric Food Chem. 2012 Mar 7;60(9):2136-47 - PubMed
  29. Curr Microbiol. 2009 Apr;58(4):338-42 - PubMed
  30. Syst Appl Microbiol. 1999 Sep;22(3):434-44 - PubMed
  31. Appl Environ Microbiol. 2011 Aug;77(15):5307-15 - PubMed
  32. Gut. 1988 Nov;29(11):1539-43 - PubMed
  33. Gastroenterology. 2001 Mar;120(4):889-99 - PubMed
  34. Br J Nutr. 2010 Oct;104(7):1007-17 - PubMed
  35. Appl Environ Microbiol. 2005 Jul;71(7):4153-5 - PubMed
  36. J Proteome Res. 2012 Dec 7;11(12):5573-85 - PubMed
  37. Br J Nutr. 2010 Aug;104 Suppl 2:S1-63 - PubMed
  38. J Agric Food Chem. 2013 Mar 13;61(10):2453-60 - PubMed
  39. J Natl Cancer Inst. 2001 Apr 4;93(7):525-33 - PubMed
  40. Nutr Rev. 2011 Jul;69(7):392-403 - PubMed
  41. Int J Food Microbiol. 2010 Feb 28;137(2-3):190-203 - PubMed
  42. Antioxid Redox Signal. 2013 May 10;18(14):1818-92 - PubMed
  43. FEMS Microbiol Ecol. 2008 Jun;64(3):482-93 - PubMed
  44. J Agric Food Chem. 2013 Jun 19;61(24):5834-40 - PubMed
  45. Appl Environ Microbiol. 1998 Sep;64(9):3336-45 - PubMed
  46. Biochem Biophys Res Commun. 2000 Oct 22;277(2):507-12 - PubMed
  47. J Nutr. 2012 Mar;142(3):470-7 - PubMed
  48. J Agric Food Chem. 2011 Dec 28;59(24):12815-20 - PubMed
  49. Br J Nutr. 2008 Jan;99(1):110-20 - PubMed
  50. J Nutr. 2003 Oct;133(10):3255S-3261S - PubMed
  51. Br J Nutr. 2010 Jul;104(2):233-40 - PubMed
  52. Br J Nutr. 2007 Sep;98(3):540-9 - PubMed
  53. Am J Clin Nutr. 2012 Jun;95(6):1323-34 - PubMed
  54. Br J Nutr. 2008 Apr;99(4):782-92 - PubMed
  55. J Agric Food Chem. 2012 Sep 12;60(36):8776-82 - PubMed
  56. Appl Microbiol Biotechnol. 1998 Feb;49(2):175-81 - PubMed
  57. Anaerobe. 2010 Oct;16(5):510-5 - PubMed

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