Display options
Cite
Garimella PS, Rennke HG, Strom JA. Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature. CEN Case Rep. 2015;4(1):20-23doi: 10.1007/s13730-014-0132-3.
Garimella, P. S., Rennke, H. G., & Strom, J. A. (2015). Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature. CEN case reports, 4(1), 20-23. https://doi.org/10.1007/s13730-014-0132-3
Garimella, Pranav S, et al. "Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature." CEN case reports vol. 4,1 (2015): 20-23. doi: https://doi.org/10.1007/s13730-014-0132-3
Garimella PS, Rennke HG, Strom JA. Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature. CEN Case Rep. 2015 Apr 01;4(1):20-23. doi: 10.1007/s13730-014-0132-3. PMID: 26101727; PMCID: PMC4473777.
Copy Download .nbib Format: NLM
Share it on

CEN Case Rep. 2015 Apr 01;4(1):20-23. doi: 10.1007/s13730-014-0132-3.

Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature.

CEN case reports

Pranav S Garimella, Helmut G Rennke, James A Strom

Affiliations

  1. Division of Nephrology, Tufts Medical Center, 800 Washington St, Box 391, Boston, MA 02411, USA, [email protected].
  2. Division of Pathology, Brigham and Women's Hospital, Boston, USA.
  3. Division of Nephrology, St. Elizabeth Medical Center, Boston, USA.

PMID: 26101727 PMCID: PMC4473777 DOI: 10.1007/s13730-014-0132-3

Abstract

Although kidney injury associated with intravenous bisphosphonate therapy is well documented, there are very few reported instances of oral bisphosphonate therapy leading to focal segmental glomerulosclerosis (FSGS) and kidney failure. We report the case of a 79-year-old woman who developed acute kidney injury due to collapsing FSGS while receiving therapy with weekly oral alendronate therapy for osteoporosis. Withdrawal of alendronate and treatment with corticosteroids resulted in partial recovery of kidney function for a period of 16 months until she developed progressive kidney failure needing long-term dialysis. This case report and the literature review highlight the fact that oral bisphosphonates may be associated with a risk of developing FSGS.

Keywords: Alendronate; Bisphosphonate; Collapsing glomerulosclerosis; Dialysis; FSGS; Proteinuria

References

  1. Osteoporos Int. 2012 Jul;23(7):2059-62 - PubMed
  2. Kidney Int. 2008 Dec;74(11):1385-93 - PubMed
  3. Kidney Int. 2004 Feb;65(2):634-41 - PubMed
  4. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6222s-6230s - PubMed
  5. NDT Plus. 2009 Feb;2(1):91-2 - PubMed
  6. J Am Soc Nephrol. 1999 Jan;10(1):51-61 - PubMed
  7. Cancer Res. 1998 Dec 1;58(23):5294-7 - PubMed
  8. J Am Soc Nephrol. 2006 Oct;17(10):2854-63 - PubMed
  9. Br J Haematol. 2002 Nov;119(2):496-9 - PubMed
  10. Am J Kidney Dis. 2006 Jun;47(6):1075-80 - PubMed
  11. Clin Exp Nephrol. 2009 Feb;13(1):85-8 - PubMed
  12. Osteoporos Int. 2007 Oct;18(10):1435-8 - PubMed
  13. Nephrol Dial Transplant. 2002 Oct;17(10):1856-7 - PubMed
  14. Proc (Bayl Univ Med Cent). 2007 Jul;20(3):249-53 - PubMed
  15. Cancer. 2000 Jun 15;88(12 Suppl):2961-78 - PubMed
  16. J Am Soc Nephrol. 2001 Jun;12(6):1164-72 - PubMed

Publication Types

Grant support