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Turgeon DK, Brenner DE. Fecal DNA-Based Detection of Colorectal Neoplasia. Curr Colorectal Cancer Rep. 2007;3(4):171-177doi: 10.1007/s11888-007-0027-1.
Turgeon, D. K., & Brenner, D. E. (2007). Fecal DNA-Based Detection of Colorectal Neoplasia. Current colorectal cancer reports, 3(4), 171-177. https://doi.org/10.1007/s11888-007-0027-1
Turgeon, D Kim, and Brenner, Dean E. "Fecal DNA-Based Detection of Colorectal Neoplasia." Current colorectal cancer reports vol. 3,4 (2007): 171-177. doi: https://doi.org/10.1007/s11888-007-0027-1
Turgeon DK, Brenner DE. Fecal DNA-Based Detection of Colorectal Neoplasia. Curr Colorectal Cancer Rep. 2007 Oct;3(4):171-177. doi: 10.1007/s11888-007-0027-1. PMID: 26078729; PMCID: PMC4465177.
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Curr Colorectal Cancer Rep. 2007 Oct;3(4):171-177. doi: 10.1007/s11888-007-0027-1.

Fecal DNA-Based Detection of Colorectal Neoplasia.

Current colorectal cancer reports

D Kim Turgeon, Dean E Brenner

PMID: 26078729 PMCID: PMC4465177 DOI: 10.1007/s11888-007-0027-1

Abstract

Human DNA fragments, as well a as whole colonocytes, can be found in stool and interrogated for mutations associated with carcinogenesis. Multiplexed panels of point mutations in fecal DNA improved the sensitivity of cancer detection (51.6%; 95% CI, 34.8%-68%) compared with fecal occult blood testing (12.9%; 95% CI, 5.1-28.9). However, the multiplex panels are not more sensitive than fecal occult blood testing in detecting advanced adenomas. Markers of epigenetic events, such as DNA methylation of gene promoters in genes not previously known to be associated with carcinogenesis or colorectal cancer, have recently been shown to be potential markers for early detection. Future approaches to improve sensitivity of fecal DNA detection of colorectal adenocarcinoma may require the inclusion of epigenetic biomarkers, the use of colonocytes isolated from feces, or both.

References

  1. Gastroenterology. 1997 Jan;112(1):17-23 - PubMed
  2. J Natl Cancer Inst. 2001 Jun 6;93(11):858-65 - PubMed
  3. Clin Colorectal Cancer. 2006 Jan;5(5):338-43 - PubMed
  4. Nat Rev Cancer. 2002 Feb;2(2):91-100 - PubMed
  5. Gastroenterology. 1977 May;72(5 Pt 1):962-75 - PubMed
  6. Cancer. 1996 Apr 15;77(8 Suppl):1707-10 - PubMed
  7. Gastroenterology. 2004 May;126(5):1270-9 - PubMed
  8. Nat Rev Cancer. 2005 Mar;5(3):199-209 - PubMed
  9. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9236-41 - PubMed
  10. BMC Cancer. 2006 May 24;6:136 - PubMed
  11. N Engl J Med. 2004 Dec 23;351(26):2704-14 - PubMed
  12. JAMA. 2003 Mar 19;289(11):1414-20 - PubMed
  13. Gastroenterology. 2000 Nov;119(5):1219-27 - PubMed
  14. Cancer. 2006 Jan 15;106(2):277-83 - PubMed
  15. Cell. 1990 Jun 1;61(5):759-67 - PubMed
  16. Science. 1992 Apr 3;256(5053):102-5 - PubMed
  17. J Natl Cancer Inst. 2005 Aug 3;97(15):1107-9 - PubMed
  18. N Engl J Med. 2000 Jul 20;343(3):162-8 - PubMed
  19. Science. 2004 Apr 23;304(5670):554 - PubMed
  20. Pathology. 1999 Aug;31(3):230-8 - PubMed
  21. Biomarkers. 2003 Jan-Feb;8(1):51-61 - PubMed
  22. J Natl Cancer Inst. 2005 Aug 3;97(15):1124-32 - PubMed
  23. Clin Cancer Res. 2005 Feb 1;11(3):1203-9 - PubMed
  24. N Engl J Med. 2002 Jan 31;346(5):311-20 - PubMed
  25. Clin Colorectal Cancer. 2003 May;3(1):47-53 - PubMed
  26. Gastroenterology. 2003 Feb;124(2):544-60 - PubMed
  27. Aliment Pharmacol Ther. 2004 Sep 1;20(5):507-15 - PubMed
  28. Cancer. 2002 Nov 15;95(10):2211-22 - PubMed
  29. Gastroenterology. 2005 Dec;129(6):1918-27 - PubMed
  30. Gastroenterology. 2005 Jan;128(1):192-206 - PubMed

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