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Weiand D, Barlow G. The rising tide of bloodstream infections with Actinomyces species: bimicrobial infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user. Oxf Med Case Reports. 2014;2014(9):156-8doi: 10.1093/omcr/omu059.
Weiand, D., & Barlow, G. (2014). The rising tide of bloodstream infections with Actinomyces species: bimicrobial infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user. Oxford medical case reports, 2014(9), 156-8. https://doi.org/10.1093/omcr/omu059
Weiand, Daniel, and Barlow, Gavin. "The rising tide of bloodstream infections with Actinomyces species: bimicrobial infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user." Oxford medical case reports vol. 2014,9 (2014): 156-8. doi: https://doi.org/10.1093/omcr/omu059
Weiand D, Barlow G. The rising tide of bloodstream infections with Actinomyces species: bimicrobial infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user. Oxf Med Case Reports. 2014 Dec 23;2014(9):156-8. doi: 10.1093/omcr/omu059. eCollection 2014 Dec. PMID: 25988064; PMCID: PMC4370021.
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Oxf Med Case Reports. 2014 Dec 23;2014(9):156-8. doi: 10.1093/omcr/omu059. eCollection 2014 Dec.

The rising tide of bloodstream infections with Actinomyces species: bimicrobial infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user.

Oxford medical case reports

Daniel Weiand, Gavin Barlow

Affiliations

  1. Medical Microbiology , Hull Royal Infirmary , Hull , UK.
  2. Infectious Diseases , Castle Hill Hospital , Castle Road, Cottingham, East Yorkshire , HU16 5JQ.

PMID: 25988064 PMCID: PMC4370021 DOI: 10.1093/omcr/omu059

Abstract

Clinicians of all specialties need to be aware of a recent, nationwide increase in the number of Actinomyces bloodstream infections. We report a case of bimicrobial bloodstream infection with Actinomyces odontolyticus and Escherichia coli in an intravenous drug user. A 36-year-old, male intravenous drug user was admitted with acute-onset pleuritic chest pain, back pain, pyrexia, tachycardia, tachypnoea and hypotension. Chest CT showed multiple, bilateral, cavitating lung lesions, most likely the result of septic emboli originating from an infected deep venous thrombosis (DVT). Blood cultures led to a mixed growth of A. odontolyticus, identified by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF), and E. coli. The rising tide of bloodstream infections with Actinomyces species is likely to continue with the increasing availability of sophisticated molecular identification techniques, including MALDI-TOF. In this case, the results of antimicrobial susceptibility tests were particularly important because the E. coli was susceptible to ciprofloxacin, whereas the A. odontolyticus was resistant.

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