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Gurusinghe S, Wallace EM, Lim R. The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia. Pregnancy Hypertens. 2013;4(1):3-6doi: 10.1016/j.preghy.2013.09.002.
Gurusinghe, S., Wallace, E. M., & Lim, R. (2014). The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia. Pregnancy hypertension, 4(1), 3-6. https://doi.org/10.1016/j.preghy.2013.09.002
Gurusinghe, Seshini, et al. "The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia." Pregnancy hypertension vol. 4,1 (2014): 3-6. doi: https://doi.org/10.1016/j.preghy.2013.09.002
Gurusinghe S, Wallace EM, Lim R. The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia. Pregnancy Hypertens. 2014 Jan;4(1):3-6. doi: 10.1016/j.preghy.2013.09.002. Epub 2013 Sep 17. PMID: 26104245.
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Pregnancy Hypertens. 2014 Jan;4(1):3-6. doi: 10.1016/j.preghy.2013.09.002. Epub 2013 Sep 17.

The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia.

Pregnancy hypertension

Seshini Gurusinghe, Euan M Wallace, Rebecca Lim

Affiliations

  1. The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.
  2. The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia; Department of Obstetrics and Gynecology, Monash University, Australia.
  3. The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia; Department of Obstetrics and Gynecology, Monash University, Australia. Electronic address: [email protected].

PMID: 26104245 DOI: 10.1016/j.preghy.2013.09.002

Abstract

Anti-angiogenic factors such as sFlt/sEng contribute to the pathology seen in preeclampsia. Activin A, which is released by the placenta following exposure to oxidative stress and elevated in preeclampsia, may interact with sFlt/sEng during the disease process. Using placental explant cultures, we determined that transcription of sFLT1, ENG and INHBA was upregulated following exposure to oxidative stress or IL-6. Explants treated with Activin A did not increase transcription of sFLT1, ENG. Conversely, treatment of placental explants with sFlt/sEng did not increase transcription of INHBA. These data may suggest that Activin A and sFlt/sEng contribute to preeclampsia via separate pathways.

Copyright © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

Keywords: Inflammation; Oxidative stress; Preeclampsia; Pregnancy

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