Display options
Cite
Løset M, Johnson MP, Melton PE, et al. Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertens. 2014;4(2):178-85doi: 10.1016/j.preghy.2014.03.005.
Løset, M., Johnson, M. P., Melton, P. E., Ang, W., Huang, R. C., Mori, T. A., Beilin, L. J., Pennell, C., Roten, L. T., Iversen, A. C., Austgulen, R., East, C. E., Blangero, J., Brennecke, S. P., & Moses, E. K. (2014). Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy hypertension, 4(2), 178-85. https://doi.org/10.1016/j.preghy.2014.03.005
Løset, Mari, et al. "Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22." Pregnancy hypertension vol. 4,2 (2014): 178-85. doi: https://doi.org/10.1016/j.preghy.2014.03.005
Løset M, Johnson MP, Melton PE, Ang W, Huang RC, Mori TA, Beilin LJ, Pennell C, Roten LT, Iversen AC, Austgulen R, East CE, Blangero J, Brennecke SP, Moses EK. Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22. Pregnancy Hypertens. 2014 Apr;4(2):178-85. doi: 10.1016/j.preghy.2014.03.005. Epub 2014 Mar 22. PMID: 26104425.
Copy Download .nbib Format: NLM
Share it on

Pregnancy Hypertens. 2014 Apr;4(2):178-85. doi: 10.1016/j.preghy.2014.03.005. Epub 2014 Mar 22.

Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22.

Pregnancy hypertension

Mari Løset, Matthew P Johnson, Phillip E Melton, Wei Ang, Rae-Chi Huang, Trevor A Mori, Lawrence J Beilin, Craig Pennell, Linda T Roten, Ann-Charlotte Iversen, Rigmor Austgulen, Christine E East, John Blangero, Shaun P Brennecke, Eric K Moses

Affiliations

  1. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway. Electronic address: [email protected].
  2. Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  3. Centre for Genetic Origins of Health and Disease, The University of Western Australia, Perth, WA 6009, Australia.
  4. School of Women's and Infants' Health, The University of Western Australia, Perth, WA 6009, Australia.
  5. School of Medicine and Pharmacology, The University of Western Australia, Perth, WA 6000, Australia; Telethon Institute for Child Health Research, The University of Western Australia, Perth, WA 6008, Australia.
  6. School of Medicine and Pharmacology, The University of Western Australia, Perth, WA 6000, Australia.
  7. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway; Central Norway Regional Health Authority (RHA), N-7501 Stjørdal, Norway.
  8. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway; Centre of Molecular Inflammation Research, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway.
  9. Department of Perinatal Medicine, Royal Women's Hospital, The University of Melbourne, Parkville, VIC 3052, Australia; Department of Obstetrics & Gynaecology, The University of Melbourne, Parkville, VIC 3052, Australia.

PMID: 26104425 DOI: 10.1016/j.preghy.2014.03.005

Abstract

OBJECTIVE: Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were recently shown to associate with known cardiovascular risk factors in a Mexican American cohort. This study aimed to further evaluate the pleiotropic effects of these preeclampsia risk variants in an independent Australian population-based cohort.

METHODS: The four SNPs were genotyped in the Western Australian Pregnancy Cohort (Raine) Study that included DNA, clinical and biochemical data from 1246 mothers and 1404 of their now adolescent offspring. Genotype association analyses were undertaken using the SOLAR software.

RESULTS: Nominal associations (P<0.05) with cardiovascular risk factors were detected for all four SNPs. The LCT SNP was associated with decreased maternal height (P=0.005) and decreased blood glucose levels in adolescents (P=0.022). The LRP1B SNP was associated with increased maternal height (P=0.026) and decreased maternal weight (P=0.044). The RND3 SNP was associated with decreased triglycerides in adolescents (P=0.001). The GCA SNP was associated with lower risk in adolescents to be born of a preeclamptic pregnancy (P=0.003) and having a mother with prior preeclamptic pregnancy (P=0.033).

CONCLUSIONS: Our collective findings support the hypothesis that genetic mechanisms for preeclampsia and CVD are, at least in part, shared, but need to be interpreted with some caution as a Bonferroni correction for multiple testing adjusted the statistical significance threshold (adjusted P<0.001).

Copyright © 2014 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

Keywords: 2q22; Cardiovascular disease (CVD); Genetic association; Preeclampsia; Raine Study

Publication Types