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Bastick AN, Runhaar J, Belo JN, et al. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015;17:152doi: 10.1186/s13075-015-0670-x.
Bastick, A. N., Runhaar, J., Belo, J. N., & Bierma-Zeinstra, S. M. (2015). Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis research & therapy, 17152. https://doi.org/10.1186/s13075-015-0670-x
Bastick, Alex N, et al. "Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies." Arthritis research & therapy vol. 17 (2015): 152. doi: https://doi.org/10.1186/s13075-015-0670-x
Bastick AN, Runhaar J, Belo JN, Bierma-Zeinstra SM. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015 Jun 08;17:152. doi: 10.1186/s13075-015-0670-x. PMID: 26050740; PMCID: PMC4483213.
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Arthritis Res Ther. 2015 Jun 08;17:152. doi: 10.1186/s13075-015-0670-x.

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies.

Arthritis research & therapy

Alex N Bastick, Jos Runhaar, Janneke N Belo, Sita M A Bierma-Zeinstra

Affiliations

  1. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, Rotterdam, 3000 CA, The Netherlands. [email protected].
  2. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, Rotterdam, 3000 CA, The Netherlands. [email protected].
  3. Department of Public Health and Primary Care, Leiden University Medical Center, PO Box 9600, Leiden, 2300 RC, The Netherlands. [email protected].
  4. Department of General Practice, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, Rotterdam, 3000 CA, The Netherlands. [email protected].

PMID: 26050740 PMCID: PMC4483213 DOI: 10.1186/s13075-015-0670-x

Abstract

INTRODUCTION: We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement.

METHOD: We searched for available observational studies up to January 2015 in Medline and Embase according to a specified search strategy. Studies that fulfilled our initial inclusion criteria were assessed for methodological quality. Data were extracted and the results were pooled, or if necessary summarized according to a best evidence synthesis.

RESULTS: Of 1,392 articles identified, 30 met the inclusion criteria and 38 determinants were investigated. Pooling was not possible due to large heterogeneity between studies. The best evidence synthesis showed strong evidence that age, ethnicity, body mass index, co-morbidity count, magnetic resonance imaging (MRI)-detected infrapatellar synovitis, joint effusion and baseline OA severity (both radiographic and clinical) are associated with clinical knee OA progression. There was moderate evidence showing that education level, vitality, pain-coping subscale resting, MRI-detected medial femorotibial cartilage loss and general bone marrow lesions are associated with clinical knee OA progression. However, evidence for the majority of determinants was limited (including knee range of motion or markers) or conflicting (including age, gender and joint line tenderness).

CONCLUSION: Strong evidence was found for multiple prognostic factors for progression of clinical knee OA. A large variety in definitions of clinical knee OA (progression) remains, which makes it impossible to summarize the evidence through meta-analyses. More research on prognostic factors for knee OA is needed using symptom progression as an outcome measure. Remarkably, only few studies have been performed using pain progression as an outcome measure. The pathophysiology of radiographic factors and their relation with symptoms should be further explored.

References

  1. Clin Orthop Relat Res. 2015 Sep;473(9):2969-89 - PubMed
  2. Arthritis Rheum. 2003 Dec;48(12):3359-70 - PubMed
  3. Ann Rheum Dis. 2004 Sep;63(9):1124-7 - PubMed
  4. Ann Rheum Dis. 2005 Dec;64(12):1727-30 - PubMed
  5. Arthritis Rheum. 2006 Oct 15;55(5):779-85 - PubMed
  6. Arthritis Rheum. 2007 Feb 15;57(1):13-26 - PubMed
  7. Ann Rheum Dis. 2007 Dec;66(12):1599-603 - PubMed
  8. Skeletal Radiol. 2008 Jul;37(7):609-17 - PubMed
  9. Osteoarthritis Cartilage. 2008 Aug;16(8):897-902 - PubMed
  10. Rheum Dis Clin North Am. 2008 Aug;34(3):515-29 - PubMed
  11. BMC Musculoskelet Disord. 2008;9:116 - PubMed
  12. Arthritis Rheum. 2009 Jan;60(1):189-98 - PubMed
  13. BMJ. 2001 Jul 28;323(7306):224-8 - PubMed
  14. Arthritis Rheum. 2002 Oct 15;47(5):556-62 - PubMed
  15. Pain. 2003 Jul;104(1-2):303-22 - PubMed
  16. Nat Clin Pract Rheumatol. 2009 Mar;5(3):149-58 - PubMed
  17. Osteoarthritis Cartilage. 2013 Sep;21(9):1185-90 - PubMed
  18. Pain. 2013 Dec;154(12):2775-81 - PubMed
  19. Arthritis Rheum. 2009 Jul 15;61(7):925-36 - PubMed
  20. Spine (Phila Pa 1976). 2009 Aug 15;34(18):1929-41 - PubMed
  21. Knee. 2009 Dec;16(6):494-500 - PubMed
  22. Osteoarthritis Cartilage. 2010 Jan;18(1):24-33 - PubMed
  23. Ann Rheum Dis. 2010 Apr;69(4):644-7 - PubMed
  24. BMC Musculoskelet Disord. 2010;11:86 - PubMed
  25. Arthritis Res Ther. 2010;12(2):R58 - PubMed
  26. Ann Rheum Dis. 2010 Oct;69(10):1816-22 - PubMed
  27. Arthritis Care Res (Hoboken). 2010 Oct;62(10):1415-25 - PubMed
  28. Arthritis Care Res (Hoboken). 2010 Nov;62(11):1527-32 - PubMed
  29. Rheumatology (Oxford). 2010 Dec;49(12):2413-9 - PubMed
  30. Ann Rheum Dis. 2011 Jan;70(1):60-7 - PubMed
  31. Arthritis Care Res (Hoboken). 2011 Aug;63(8):1115-25 - PubMed
  32. BMC Musculoskelet Disord. 2011;12:269 - PubMed
  33. Osteoarthritis Cartilage. 2012 May;20(5):388-95 - PubMed
  34. Arthritis Rheum. 2012 May;64(5):1447-56 - PubMed
  35. Joint Bone Spine. 2012 May;79(3):298-303 - PubMed
  36. Osteoarthritis Cartilage. 2012 Jun;20(6):503-10 - PubMed
  37. Ann Rheum Dis. 2012 Sep;71(9):1517-23 - PubMed
  38. Arthritis Care Res (Hoboken). 2013 Jan;65(1):15-22 - PubMed
  39. Ann Rheum Dis. 2013 May;72(5):707-14 - PubMed
  40. Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53 - PubMed
  41. Osteoarthritis Cartilage. 2013 Dec;21(12):1865-75 - PubMed
  42. Osteoarthritis Cartilage. 2014 Jan;22(1):71-5 - PubMed
  43. Ann Rheum Dis. 2014 May;73(5):824-30 - PubMed
  44. Osteoarthritis Cartilage. 2014 May;22(5):622-30 - PubMed
  45. Ann Rheum Dis. 2014 Jul;73(7):1369-75 - PubMed
  46. Rheumatology (Oxford). 2014 Sep;53(9):1625-9 - PubMed
  47. Radiology. 2015 Mar;274(3):810-20 - PubMed
  48. Arthritis Rheumatol. 2015 Mar;67(3):714-23 - PubMed
  49. Arthritis Rheumatol. 2015 Mar;67(3):724-32 - PubMed

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