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Jiao HC, Ju JQ, Li YL, et al. Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2015;23(3):494-504doi: 10.1016/j.ctim.2015.04.002.
Jiao, H. C., Ju, J. Q., Li, Y. L., Ma, X. S., Jiang, H. Q., Zhao, J., Shen, Z. Z., & Yang, W. Q. (2015). Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine, 23(3), 494-504. https://doi.org/10.1016/j.ctim.2015.04.002
Jiao, Hua-Chen, et al. "Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials." Complementary therapies in medicine vol. 23,3 (2015): 494-504. doi: https://doi.org/10.1016/j.ctim.2015.04.002
Jiao HC, Ju JQ, Li YL, Ma XS, Jiang HQ, Zhao J, Shen ZZ, Yang WQ. Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2015 Jun;23(3):494-504. doi: 10.1016/j.ctim.2015.04.002. Epub 2015 Apr 09. PMID: 26051585.
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Complement Ther Med. 2015 Jun;23(3):494-504. doi: 10.1016/j.ctim.2015.04.002. Epub 2015 Apr 09.

Efficacy of Chinese herbal medicine on health-related quality of life (SF-36) in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials.

Complementary therapies in medicine

Hua-Chen Jiao, Jian-Qing Ju, Yun-Lun Li, Xue-Sheng Ma, Hai-Qiang Jiang, Jing Zhao, Zhen-Zhen Shen, Wen-Qing Yang

Affiliations

  1. Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 42, Cultural West Road, Jinan 250011, Shandong Province, People's Republic of China.
  2. Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China.
  3. Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 42, Cultural West Road, Jinan 250011, Shandong Province, People's Republic of China; Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China. Electronic address: [email protected].
  4. School of Natural Medicine, University of the Western Cape, Private Bag X1, Bellville 7535, South Africa.

PMID: 26051585 DOI: 10.1016/j.ctim.2015.04.002

Abstract

OBJECTIVES: This study aims to evaluate published randomized controlled trials (RCTs) of Chinese Herbal Medicine (CHM) improving health-related quality of life (HRQL) in hypertensive patients that employ the Short-Form 36-Item Health questionnaire (SF-36) as an outcome measure.

METHODS: Five electronic databases were searched up to October 2013 to identify RCTs of CHM for hypertension. The primary outcome was SF-36. Trial selection, data extraction, methodological quality assessment, and data analyses were conducted according to the Cochrane handbook.

RESULTS: Eleven RCTs with total of 1043 participants were identified. The majority of the included trials were assessed to be of poor methodological quality and high clinical heterogeneity. Meta-analysis shows a significant improvement both in physical component summary (PCS) measure and mental component summary (MCS) measure of SF-36, with physical functioning (WMD=8.54[5.34, 11.74], p<0.001), role physical (WMD=13.32[7.03, 19.61], p<0.001), bodily pain (WMD=10.53[6.46, 14.60], p<0.001), general health (WMD=-5.56[2.09, 9.02], p<0.001), vitality (WMD=6.84[4.33, 9.53], p<0.001), social functioning (WMD=7.50[2.63, 12.36], p<0.001), role emotional (WMD=12.06[4.45, 19.68], p<0.001) and mental health (WMD=-5.68[2.90, 8.47], p<0.001). CHM can also decrease systolic blood pressure (WMD=-4.45 [-6.71, -2.19], p<0.001) and relieve symptoms related to hypertension.

CONCLUSIONS: CHM appears to have beneficial effects on improvement of HRQL in hypertensive patients. However, the findings should be interpreted with caution due to the poor methodological quality and high clinical heterogeneity of the included trials. Further clinical trials should be carried out to provide more reliable evidence.

Copyright © 2015 Elsevier Ltd. All rights reserved.

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