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Bing YH, Wu MC, Chu CP, et al. Facial stimulation induces long-term depression at cerebellar molecular layer interneuron-Purkinje cell synapses in vivo in mice. Front Cell Neurosci. 2015;9:214doi: 10.3389/fncel.2015.00214.
Bing, Y. H., Wu, M. C., Chu, C. P., & Qiu, D. L. (2015). Facial stimulation induces long-term depression at cerebellar molecular layer interneuron-Purkinje cell synapses in vivo in mice. Frontiers in cellular neuroscience, 9214. https://doi.org/10.3389/fncel.2015.00214
Bing, Yan-Hua, et al. "Facial stimulation induces long-term depression at cerebellar molecular layer interneuron-Purkinje cell synapses in vivo in mice." Frontiers in cellular neuroscience vol. 9 (2015): 214. doi: https://doi.org/10.3389/fncel.2015.00214
Bing YH, Wu MC, Chu CP, Qiu DL. Facial stimulation induces long-term depression at cerebellar molecular layer interneuron-Purkinje cell synapses in vivo in mice. Front Cell Neurosci. 2015 Jun 09;9:214. doi: 10.3389/fncel.2015.00214. eCollection 2015. PMID: 26106296; PMCID: PMC4460530.
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Front Cell Neurosci. 2015 Jun 09;9:214. doi: 10.3389/fncel.2015.00214. eCollection 2015.

Facial stimulation induces long-term depression at cerebellar molecular layer interneuron-Purkinje cell synapses in vivo in mice.

Frontiers in cellular neuroscience

Yan-Hua Bing, Mao-Cheng Wu, Chun-Ping Chu, De-Lai Qiu

Affiliations

  1. Cellular Function Research Center, Yanbian University Yanji, Jilin Province, China ; Department of Physiology and Pathophysiology, College of Medicine, Yanbian University Yanji, Jilin Province, China.
  2. Cellular Function Research Center, Yanbian University Yanji, Jilin Province, China ; Department of Osteology, Affiliated Hospital of Yanbian University Yanji, Jilin Province, China.
  3. Cellular Function Research Center, Yanbian University Yanji, Jilin Province, China.

PMID: 26106296 PMCID: PMC4460530 DOI: 10.3389/fncel.2015.00214

Abstract

Cerebellar long-term synaptic plasticity has been proposed to provide a cellular mechanism for motor learning. Numerous studies have demonstrated the induction and mechanisms of synaptic plasticity at parallel fiber-Purkinje cell (PF-PC), parallel fiber-molecular layer interneurons (PF-MLI) and mossy fiber-granule cell (MF-GC) synapses, but no study has investigated sensory stimulation-evoked synaptic plasticity at MLI-PC synapses in the cerebellar cortex of living animals. We studied the expression and mechanism of MLI-PC GABAergic synaptic plasticity induced by a train of facial stimulation in urethane-anesthetized mice by cell-attached recordings and pharmacological methods. We found that 1 Hz, but not a 2 Hz or 4 Hz, facial stimulation induced a long-term depression (LTD) of GABAergic transmission at MLI-PC synapses, which was accompanied with a decrease in the stimulation-evoked pause of spike firing in PCs, but did not induce a significant change in the properties of the sensory-evoked spike events of MLIs. The MLI-PC GABAergic LTD could be prevented by blocking cannabinoid type 1 (CB1) receptors, and could be pharmacologically induced by a CB1 receptor agonist. Additionally, 1 Hz facial stimulation delivered in the presence of a metabotropic glutamate receptor 1 (mGluR1) antagonist, JNJ16259685, still induced the MLI-PC GABAergic LTD, whereas blocking N-methyl-D-aspartate (NMDA) receptors during 1 Hz facial stimulation abolished the expression of MLI-PC GABAergic LTD. These results indicate that sensory stimulation can induce an endocannabinoid (eCB)-dependent LTD of GABAergic transmission at MLI-PC synapses via activation of NMDA receptors in cerebellar cortical Crus II in vivo in mice. Our results suggest that the sensory stimulation-evoked MLI-PC GABAergic synaptic plasticity may play a critical role in motor learning in animals.

Keywords: NMDA receptor; cerebellar Purkinje cell; endocannabinoids receptor; in vivo cell-attached recording; molecular layer interneuron; plasticity; sensory stimulation

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