Front Cell Neurosci. 2015 Jun 08;9:217. doi: 10.3389/fncel.2015.00217. eCollection 2015.

Emerging roles of Axin in cerebral cortical development.

Frontiers in cellular neuroscience

Tao Ye, Amy K Y Fu, Nancy Y Ip

PMID: 26106297 PMCID: PMC4458687 DOI: 10.3389/fncel.2015.00217

Abstract

Proper functioning of the cerebral cortex depends on the appropriate production and positioning of neurons, establishment of axon-dendrite polarity, and formation of proper neuronal connectivity. Deficits in any of these processes greatly impair neural functions and are associated with various human neurodevelopmental disorders including microcephaly, cortical heterotopias, and autism. The application of in vivo manipulation techniques such as in utero electroporation has resulted in significant advances in our understanding of the cellular and molecular mechanisms that underlie neural development in vivo. Axin is a scaffold protein that regulates neuronal differentiation and morphogenesis in vitro. Recent studies provide novel insights into the emerging roles of Axin in gene expression and cytoskeletal regulation during neurogenesis, neuronal polarization, and axon formation. This review summarizes current knowledge on Axin as a key molecular controller of cerebral cortical development.

Keywords: Axin; axon formation; cerebral cortex; cytoskeletal regulation; neurogenesis; polarization

References

1. Curr Opin Cell Biol. 2008 Dec;20(6):707-15 - PubMed
2. Neuron. 2000 Jul;27(1):33-44 - PubMed
3. Annu Rev Neurosci. 2002;25:127-49 - PubMed
4. Neuron. 2005 May 5;46(3):383-8 - PubMed
5. Cell. 2009 Mar 20;136(6):1017-31 - PubMed
6. Nature. 2005 Oct 27;437(7063):1370-5 - PubMed
7. Nat Neurosci. 2001 Aug;4(8):781-2 - PubMed
8. JAMA. 2011 Nov 9;306(18):2001-10 - PubMed
9. Curr Opin Cell Biol. 2005 Dec;17(6):648-57 - PubMed
10. Neuron. 2004 Mar 25;41(6):881-90 - PubMed
11. Nat Rev Mol Cell Biol. 2005 Oct;6(10):777-88 - PubMed
12. Nat Rev Neurosci. 2007 Jun;8(6):427-37 - PubMed
13. Mol Cell Biol. 2001 Aug;21(15):5132-41 - PubMed
14. EMBO J. 2004 Jun 2;23 (11):2235-45 - PubMed
15. Cell Rep. 2014 Dec 11;9(5):1635-43 - PubMed
16. Elife. 2014 Jul 29;3:e02663 - PubMed
17. Nat Neurosci. 2004 Feb;7(2):136-44 - PubMed
18. Nat Neurosci. 2001 Feb;4(2):143-50 - PubMed
19. Cereb Cortex. 2009 Oct;19(10):2439-50 - PubMed
20. J Cell Sci. 2005 Mar 1;118(Pt 5):993-1005 - PubMed
21. Dev Biol. 2001 Dec 1;240(1):237-46 - PubMed
22. EMBO J. 2006 Apr 19;25(8):1646-58 - PubMed
23. Am J Hum Genet. 2000 May;66(5):1705-9 - PubMed
24. Neuron. 2013 Aug 21;79(4):665-79 - PubMed
25. J Neurosci. 2011 Sep 21;31(38):13613-24 - PubMed
26. Curr Opin Neurobiol. 2005 Feb;15(1):29-33 - PubMed
27. Neuroscience. 2001;103(4):865-72 - PubMed
28. J Cell Sci. 2004 Nov 15;117(Pt 24):5721-9 - PubMed
29. Curr Biol. 2001 Jan 9;11(1):44-9 - PubMed
30. Neuron. 2003 Mar 6;37(5):751-64 - PubMed
31. J Neurosci. 2002 Apr 15;22(8):3161-73 - PubMed
32. Neurosignals. 2004 May-Jun;13(3):99-113 - PubMed
33. Neuron. 2012 Oct 18;76(2):353-69 - PubMed
34. J Comp Neurol. 2002 Dec 2;454(1):1-14 - PubMed
35. Genes Dev. 2008 Jan 1;22(1):106-20 - PubMed
36. Nat Rev Neurosci. 2010 Aug;11(8):539-51 - PubMed
37. J Neurosci. 2010 Dec 15;30(50):16766-76 - PubMed
38. Cell. 2007 May 4;129(3):565-77 - PubMed
39. ACS Chem Neurosci. 2012 Nov 21;3(11):963-71 - PubMed
40. Cell Signal. 1999 Nov;11(11):777-88 - PubMed
41. Genes Dev. 2001 Jun 1;15(11):1427-34 - PubMed
42. Dev Neurosci. 2008;30(1-3):24-32 - PubMed
43. Cell. 1997 Jul 11;90(1):181-92 - PubMed
44. Prog Neurobiol. 2005 Sep-Oct;77(1-2):38-56 - PubMed
45. Nature. 2009 Oct 1;461(7264):614-20 - PubMed
46. Cell. 2007 Jan 12;128(1):29-43 - PubMed
47. Cell. 2010 Jul 9;142(1):144-57 - PubMed
48. Cell. 2005 Jan 14;120(1):137-49 - PubMed

Publication Types

• Journal Article
• Review