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Narciso-Schiavon JL, Schiavon Lde L. Autoantibodies in chronic hepatitis C: A clinical perspective. World J Hepatol. 2015;7(8):1074-85doi: 10.4254/wjh.v7.i8.1074.
Narciso-Schiavon, J. L., & Schiavon, L. d. e. . L. (2015). Autoantibodies in chronic hepatitis C: A clinical perspective. World journal of hepatology, 7(8), 1074-85. https://doi.org/10.4254/wjh.v7.i8.1074
Narciso-Schiavon, Janaína Luz, and Schiavon, Leonardo de Lucca. "Autoantibodies in chronic hepatitis C: A clinical perspective." World journal of hepatology vol. 7,8 (2015): 1074-85. doi: https://doi.org/10.4254/wjh.v7.i8.1074
Narciso-Schiavon JL, Schiavon Lde L. Autoantibodies in chronic hepatitis C: A clinical perspective. World J Hepatol. 2015 May 18;7(8):1074-85. doi: 10.4254/wjh.v7.i8.1074. PMID: 26052396; PMCID: PMC4450184.
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World J Hepatol. 2015 May 18;7(8):1074-85. doi: 10.4254/wjh.v7.i8.1074.

Autoantibodies in chronic hepatitis C: A clinical perspective.

World journal of hepatology

Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon

Affiliations

  1. Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon, Department of Internal Medicine, Gastroenterology Division, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil.

PMID: 26052396 PMCID: PMC4450184 DOI: 10.4254/wjh.v7.i8.1074

Abstract

Non-organ-specific autoantibodies and thyroid autoantibodies have been frequently found in chronic carriers of hepatitis C virus (HCV). With respect to endomysial antibodies and tissue transglutaminase, it is controversial whether the prevalence of gluten-related seromarkers is higher in patients with HCV. In such cases, in addition to acknowledging any currently existing autoimmune disease, recognizing the risk of the patient developing an autoimmune disease during interferon (IFN)-based treatment must be a principle concern. From a clinical point-of-view, the presence of autoantibodies arouses suspicion that an autoimmune disease may be present or may be precipitated by IFN-based HCV treatment. In this paper, we review the prevalence of autoantibodies in individuals with hepatitis C, the clinical significance of these autoantibodies, and the approach recommended for such situations.

Keywords: Antibodies; Antinuclear; Autoimmune; Autoimmunity; Celiac disease; Diarrhea; Hashimoto disease; Hepatitis; Hepatitis C; Interferon-alpha; Thyroglobulin; Thyroid diseases; Transglutaminases

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