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Zhang L, Chong L, Cho J, et al. Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?. Asia Pac J Ophthalmol (Phila). 2012;1(6):374-83doi: 10.1097/APO.0b013e31827a9969.
Zhang, L., Chong, L., Cho, J., Liao, P. C., Shen, F., & Leung, Y. F. (2012). Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 1(6), 374-83. https://doi.org/10.1097/APO.0b013e31827a9969
Zhang, Liyun, et al. "Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?." Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) vol. 1,6 (2012): 374-83. doi: https://doi.org/10.1097/APO.0b013e31827a9969
Zhang L, Chong L, Cho J, Liao PC, Shen F, Leung YF. Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?. Asia Pac J Ophthalmol (Phila). 2012 Nov-Dec;1(6):374-83. doi: 10.1097/APO.0b013e31827a9969. PMID: 26107731.
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Asia Pac J Ophthalmol (Phila). 2012 Nov-Dec;1(6):374-83. doi: 10.1097/APO.0b013e31827a9969.

Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery?.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Liyun Zhang, Leelyn Chong, Jin Cho, Pin-Chao Liao, Feichen Shen, Yuk Fai Leung

Affiliations

  1. From the *Department of Biological Sciences, Purdue University; and †Department of Biochemistry and Molecular Biology, Indiana University School of Medicine Lafayette, West Lafayette, IN.

PMID: 26107731 DOI: 10.1097/APO.0b013e31827a9969

Abstract

The molecular basis of many early-onset eye diseases has been uncovered, but the number of available drug treatments for improving deteriorated vision is still scarce. Consequently, there is a high demand for new drugs to treat these diseases. This review first provides a brief synopsis of the use of zebrafish model for screening drugs with vision benefits. In particular, visual-motor response, the activity response of larvae to a change in light stimuli, is proposed to serve as a simple and efficient tool for screening drugs that may improve vision in various zebrafish visual mutants. The second part of the review discusses the identification of novel drug candidates, with particular emphasis on naturally derived chemicals including traditional Chinese medicines and nutritional therapies on retinal degenerative diseases. Many of these chemicals have been used in neuroprotection and/or have been consumed by many populations for good health and vision; thus, the screening of these chemicals with various zebrafish visual mutants would expedite the development of novel drugs for treating early-onset eye diseases.

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