Display options
Cite
Rozema JJ, Koppen C, Bral N, et al. Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal Cross-Linking. Asia Pac J Ophthalmol (Phila). 2013;2(1):15-9doi: 10.1097/APO.0b013e3182729df0.
Rozema, J. J., Koppen, C., Bral, N., & Tassignon, M. J. (2013). Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal Cross-Linking. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 2(1), 15-9. https://doi.org/10.1097/APO.0b013e3182729df0
Rozema, Jos J, et al. "Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal Cross-Linking." Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) vol. 2,1 (2013): 15-9. doi: https://doi.org/10.1097/APO.0b013e3182729df0
Rozema JJ, Koppen C, Bral N, Tassignon MJ. Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal Cross-Linking. Asia Pac J Ophthalmol (Phila). 2013 Jan-Feb;2(1):15-9. doi: 10.1097/APO.0b013e3182729df0. PMID: 26107862.
Copy Download .nbib Format: NLM
Share it on

Asia Pac J Ophthalmol (Phila). 2013 Jan-Feb;2(1):15-9. doi: 10.1097/APO.0b013e3182729df0.

Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal Cross-Linking.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Jos J Rozema, Carina Koppen, Nathalie Bral, Marie-José Tassignon

Affiliations

  1. From the *Department of Ophthalmology, Antwerp University Hospital, Edegem; and †Department of Medicine, Antwerp University, Wilrijk, Belgium.

PMID: 26107862 DOI: 10.1097/APO.0b013e3182729df0

Abstract

PURPOSE: To study the forward and backward light scatter in keratoconic corneas before and after cross-linking.

DESIGN: An institutional, prospective, cross-sectional study was conducted.

METHODS: This study includes 35 eyes of 25 patients with keratoconus scheduled for either standard corneal collagen cross-linking with riboflavin (CXL) or transepithelial corneal cross-linking (TE-CXL). A group of 26 healthy myopic eyes from 26 prerefractive patients was included as normal reference. Before and 6 months after cross-linking, forward light scatter was measured using the compensation comparison method, whereas backward light scatter was measured using Scheimpflug imaging.

RESULTS: In keratoconic eyes, backward light scatter originating from the corneal stroma was [mean (SD)] 27.2% (8.2%) higher than in the normal eyes (P < 0.001). In the anterior stroma, this increased backscatter was significantly correlated with the maximum corneal curvature Kmax as a measure of keratoconus severity (Pearson ρ = 0.582, P = 0.003). For forward light scatter, no significant difference was seen between the normal and keratoconus groups, nor was there any correlation with keratoconus severity. After CXL, the backscatter increased significantly by [mean (SD)] 33.0% (9.5%) in the entire corneal stroma (P = 0.001), whereas for TE-CXL, no significant increase was seen. Forward scatter increased significantly by [mean (SD)] 0.10 (0.10) log units (P = 0.009) and 0.09 (0.10) log units (P = 0.003) for CXL and TE-CXL, respectively, which is near the detection limit for an average patient.

CONCLUSIONS: Unlike TE-CXL, CXL increases the already-elevated stromal backscatter in keratoconus. Forward scatter increases equally for both techniques.

Publication Types