Display options
Cite
Cavasin MA, Stenmark KR, McKinsey TA. Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series). Pulm Circ. 2015;5(1):63-72doi: 10.1086/679700.
Cavasin, M. A., Stenmark, K. R., & McKinsey, T. A. (2015). Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series). Pulmonary circulation, 5(1), 63-72. https://doi.org/10.1086/679700
Cavasin, Maria A, et al. "Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series)." Pulmonary circulation vol. 5,1 (2015): 63-72. doi: https://doi.org/10.1086/679700
Cavasin MA, Stenmark KR, McKinsey TA. Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series). Pulm Circ. 2015 Mar;5(1):63-72. doi: 10.1086/679700. PMID: 25992271; PMCID: PMC4405717.
Copy Download .nbib Format: NLM
Share it on

Pulm Circ. 2015 Mar;5(1):63-72. doi: 10.1086/679700.

Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series).

Pulmonary circulation

Maria A Cavasin, Kurt R Stenmark, Timothy A McKinsey

Affiliations

  1. Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, Colorado, USA.
  2. Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA.

PMID: 25992271 PMCID: PMC4405717 DOI: 10.1086/679700

Abstract

Reversible lysine acetylation has emerged as a critical mechanism for controlling the function of nucleosomal histones as well as diverse nonhistone proteins. Acetyl groups are conjugated to lysine residues in proteins by histone acetyltransferases and removed by histone deacetylases (HDACs), which are also commonly referred to as lysine deacetylases. Over the past decade, many studies have shown that HDACs play crucial roles in the control of left ventricular (LV) cardiac remodeling in response to stress. Small molecule HDAC inhibitors block pathological hypertrophy and fibrosis and improve cardiac function in various preclinical models of LV failure. Only recently have HDACs been studied in the context of right ventricular (RV) failure, which commonly occurs in patients who experience pulmonary hypertension (PH). Here, we review recent findings with HDAC inhibitors in models of PH and RV remodeling, propose next steps for this newly uncovered area of research, and highlight potential for isoform-selective HDAC inhibitors for the treatment of PH and RV failure.

Keywords: epigenetics; histone deacetylases; pulmonary hypertension; right ventricle

References

  1. Curr Cardiol Rev. 2009 Jan;5(1):22-8 - PubMed
  2. Curr Hypertens Rep. 2013 Dec;15(6):614-22 - PubMed
  3. EMBO J. 1999 Sep 15;18(18):5099-107 - PubMed
  4. Circulation. 2013 Apr 9;127(14):e540 - PubMed
  5. Hypertension. 2010 Sep;56(3):437-44 - PubMed
  6. Curr Cancer Drug Targets. 2010 Dec;10(8):898-913 - PubMed
  7. Circ J. 2010 Apr;74(4):760-70 - PubMed
  8. J Mol Cell Cardiol. 2011 Jul;51(1):41-50 - PubMed
  9. Nat Chem Biol. 2013 May;9(5):319-25 - PubMed
  10. EMBO J. 2010 Mar 3;29(5):969-80 - PubMed
  11. Pulm Circ. 2013 Jan;3(1):226-44 - PubMed
  12. Circ Res. 2010 Feb 5;106(2):272-84 - PubMed
  13. J Biol Chem. 2005 Dec 2;280(48):40282-92 - PubMed
  14. Kidney Blood Press Res. 2013;37(4-5):229-39 - PubMed
  15. Cardiovasc Res. 2007 Dec 1;76(3):473-81 - PubMed
  16. Oncogene. 2002 Jan 17;21(3):427-36 - PubMed
  17. J Mol Cell Cardiol. 2011 Oct;51(4):491-6 - PubMed
  18. J Pharmacol Exp Ther. 2012 Apr;341(1):285-93 - PubMed
  19. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7835-40 - PubMed
  20. Circulation. 2012 Jul 24;126(4):455-67 - PubMed
  21. Circulation. 2013 Apr 9;127(14):e539 - PubMed
  22. Echocardiography. 1997 Mar;14(2):189-206 - PubMed
  23. J Mol Biol. 2004 Apr 16;338(1):17-31 - PubMed
  24. J Biol Chem. 2011 Sep 30;286(39):34346-55 - PubMed
  25. Biochem Soc Trans. 2009 Oct;37(Pt 5):1126-32 - PubMed
  26. J Biol Chem. 2011 Feb 18;286(7):5567-77 - PubMed
  27. Nature. 2000 Feb 17;403(6771):795-800 - PubMed
  28. J Clin Invest. 2003 Sep;112(6):863-71 - PubMed
  29. J Clin Invest. 2006 Jul;116(7):1853-64 - PubMed
  30. Expert Opin Investig Drugs. 2009 Nov;18(11):1605-17 - PubMed
  31. Cancer Lett. 2013 Feb 28;329(2):174-80 - PubMed
  32. Annu Rev Pharmacol Toxicol. 2012;52:303-19 - PubMed
  33. Annu Rev Physiol. 2013;75:23-47 - PubMed
  34. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14400-5 - PubMed
  35. Circulation. 2006 Jun 6;113(22):2579-88 - PubMed
  36. Circulation. 2009 Nov 17;120(20):1951-60 - PubMed
  37. J Am Chem Soc. 2010 Aug 11;132(31):10842-6 - PubMed
  38. Circulation. 2012 Jan 3;125(1):e2-e220 - PubMed
  39. Biochem Biophys Res Commun. 2009 Jan 30;379(1):1-5 - PubMed
  40. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H968-77 - PubMed
  41. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40 - PubMed
  42. Oncogene. 2006 Jul 27;25(32):4495-500 - PubMed
  43. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1859-63 - PubMed
  44. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94 - PubMed
  45. Circ Res. 2014 Jan 3;114(1):67-78 - PubMed
  46. Trends Cell Biol. 2008 Jun;18(6):291-7 - PubMed
  47. J Immunol. 2011 Sep 1;187(5):2711-22 - PubMed
  48. Curr Opin Genet Dev. 2008 Oct;18(5):404-10 - PubMed
  49. Cell Rep. 2012 Aug 30;2(2):419-31 - PubMed
  50. J Med Chem. 2007 Nov 15;50(23):5543-6 - PubMed
  51. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11 - PubMed
  52. Circ Res. 2012 Mar 2;110(5):739-48 - PubMed
  53. Am J Respir Crit Care Med. 2011 May 15;183(10 ):1402-10 - PubMed
  54. Mol Cell Biol. 2004 Oct;24(19):8374-85 - PubMed
  55. Mol Cell Biol. 2006 May;26(10):3875-88 - PubMed
  56. Nat Chem Biol. 2010 Mar;6(3):238-243 - PubMed
  57. Mol Cell Biol. 1999 Nov;19(11):7816-27 - PubMed
  58. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4070-5 - PubMed
  59. Mol Cell Biol. 2001 Sep;21(18):6312-21 - PubMed
  60. FEBS Lett. 2010 Feb 5;584(3):631-7 - PubMed
  61. J Mol Cell Cardiol. 2009 Dec;47(6):770-80 - PubMed
  62. Chem Biol. 2012 Jun 22;19(6):669-73 - PubMed
  63. Science. 2009 Aug 14;325(5942):834-40 - PubMed
  64. Circulation. 2006 Jan 3;113(1):51-9 - PubMed
  65. J Am Coll Cardiol. 2009 Apr 28;53(17):1573-619 - PubMed
  66. J Biol Chem. 2000 May 19;275(20):15594-9 - PubMed
  67. J Med Chem. 2004 Oct 7;47(21):5235-43 - PubMed
  68. Biopolymers. 2013 Feb;99(2):112-26 - PubMed
  69. Bioorg Med Chem Lett. 2008 Jan 15;18(2):726-31 - PubMed
  70. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8 - PubMed
  71. Nature. 2007 Jun 14;447(7146):859-63 - PubMed
  72. Mol Cell. 2000 Aug;6(2):233-44 - PubMed
  73. J Biol Chem. 2001 Dec 14;276(50):47496-507 - PubMed
  74. EMBO J. 1999 Sep 15;18(18):5085-98 - PubMed
  75. ACS Med Chem Lett. 2010 Oct 8;2(1):39-42 - PubMed
  76. J Mol Cell Cardiol. 2008 Dec;45(6):715-23 - PubMed
  77. Mol Cell Biol. 2008 May;28(10):3437-45 - PubMed
  78. FASEB J. 2008 Oct;22(10):3549-60 - PubMed
  79. Autophagy. 2007 Nov-Dec;3(6):643-5 - PubMed
  80. ChemMedChem. 2009 May;4(5):842-52 - PubMed
  81. Eur Respir J. 2012 Dec;40(6):1555-65 - PubMed
  82. Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908 - PubMed
  83. FASEB J. 2005 Jun;19(8):966-8 - PubMed
  84. Cardiovasc Res. 2007 Mar 1;73(4):667-77 - PubMed
  85. Mol Endocrinol. 2010 Jul;24(7):1349-58 - PubMed
  86. J Med Chem. 2012 Nov 26;55(22):9562-75 - PubMed
  87. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8 - PubMed
  88. Nature. 2000 Nov 2;408(6808):106-11 - PubMed
  89. J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):13S-24S - PubMed

Publication Types

Grant support