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Kato T, Kakuta Y, Yamanaka K, et al. Early diagnosis and treatment of breast cancer in Japanese kidney transplant recipients: a single center experience. Springerplus. 2015;4:196doi: 10.1186/s40064-015-0946-2.
Kato, T., Kakuta, Y., Yamanaka, K., Okumi, M., Abe, T., Imamura, R., Ichimaru, N., Takahara, S., & Nonomura, N. (2015). Early diagnosis and treatment of breast cancer in Japanese kidney transplant recipients: a single center experience. SpringerPlus, 4196. https://doi.org/10.1186/s40064-015-0946-2
Kato, Taigo, et al. "Early diagnosis and treatment of breast cancer in Japanese kidney transplant recipients: a single center experience." SpringerPlus vol. 4 (2015): 196. doi: https://doi.org/10.1186/s40064-015-0946-2
Kato T, Kakuta Y, Yamanaka K, Okumi M, Abe T, Imamura R, Ichimaru N, Takahara S, Nonomura N. Early diagnosis and treatment of breast cancer in Japanese kidney transplant recipients: a single center experience. Springerplus. 2015 Apr 25;4:196. doi: 10.1186/s40064-015-0946-2. eCollection 2015. PMID: 25992308; PMCID: PMC4431989.
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Springerplus. 2015 Apr 25;4:196. doi: 10.1186/s40064-015-0946-2. eCollection 2015.

Early diagnosis and treatment of breast cancer in Japanese kidney transplant recipients: a single center experience.

SpringerPlus

Taigo Kato, Yoichi Kakuta, Kazuaki Yamanaka, Masayoshi Okumi, Toyofumi Abe, Ryoichi Imamura, Naotsugu Ichimaru, Shiro Takahara, Norio Nonomura

Affiliations

  1. Department of Urology, Osaka University Graduate School of Medicine, 2-2 E4 Yamadaoka, Suita, Osaka, 565-0871 Japan.
  2. Department of Urology, Tokyo Women's Medical University Graduate School of Medicine, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo, 162-8666 Japan.
  3. Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871 Japan.

PMID: 25992308 PMCID: PMC4431989 DOI: 10.1186/s40064-015-0946-2

Abstract

BACKGROUND: The incidence of malignancies in kidney transplant recipients is increasing. Breast cancer is a common malignancy after kidney transplantation and can be more aggressive in kidney transplant recipients than in the general population. In this study, we evaluated the incidence and prognosis of breast cancer in kidney transplant recipients.

FINDINGS: Between 1993 and 2013, 750 kidney transplant patients were followed-up at our center. Since 1999, annual physical examination, mammography, and breast ultrasonography have been performed for such patients. Diagnostic studies, including core needle or mammotome biopsy, were performed for suspected malignancies. Patients with malignant neoplasm were administered the appropriate treatment and followed-up to assess tumor response and symptoms. Nine patients were diagnosed with breast cancer during the follow-up period. The mean age at the initial detection of the breast cancer was 47.7 ± 8.4 years. The mean interval from transplantation to diagnosis was 148.7 ± 37.1 months. Of the 9 patients, 8 were detected through the screening test; 7 were treated with breast conservative surgery and 1 was treated with modified radical mastectomy. The cancer stages were 0 (n = 2), I (n = 6), and II (n = 1). The incidence of breast cancer tended to be unchanged with time between transplantation and diagnosis, inconsistent with the increase in the duration of immunosuppression.

CONCLUSION: Annual screening tests are crucial in the early diagnosis of breast cancer. Early treatment of breast cancer can result in an excellent prognosis in kidney transplant recipients.

Keywords: Breast cancer; Kidney transplantation; Prognosis; Screening

References

  1. Am J Transplant. 2004 Mar;4(3):378-83 - PubMed
  2. JAMA. 2011 Nov 2;306(17):1891-901 - PubMed
  3. BMJ. 2010 Feb 11;340:c570 - PubMed
  4. N Engl J Med. 2012 Feb 9;366(6):520-9 - PubMed
  5. Lancet. 2000 May 27;355(9218):1886-7 - PubMed
  6. Kidney Int. 2004 Jul;66(1):383-9 - PubMed
  7. Asian Pac J Cancer Prev. 2013;14(5):3037-40 - PubMed
  8. Ann Intern Med. 2002 Sep 3;137(5 Part 1):347-60 - PubMed
  9. Am Surg. 2006 Feb;72(2):150-3 - PubMed
  10. Am J Transplant. 2008 Nov;8(11):2185-91 - PubMed
  11. Transplantation. 2005 Oct 15;80(2 Suppl):S254-64 - PubMed
  12. World J Surg Oncol. 2013 Mar 22;11:77 - PubMed
  13. Radiographics. 2003 Jul-Aug;23 (4):881-95 - PubMed
  14. Lancet. 1995 Sep 23;346(8978):796-8 - PubMed
  15. Jpn J Clin Oncol. 2013 Mar;43(3):328-36 - PubMed
  16. Am J Transplant. 2004 Jun;4(6):905-13 - PubMed
  17. J Am Soc Nephrol. 2000 Oct;11 Suppl 15:S1-86 - PubMed
  18. Transplantation. 2011 Aug 15;92(3):303-10 - PubMed
  19. Lancet. 2007 Jul 7;370(9581):59-67 - PubMed
  20. Transpl Int. 2006 Aug;19(8):607-20 - PubMed
  21. Transplantation. 2009 Apr 27;87(8 Suppl):S19-22 - PubMed
  22. Transplantation. 2003 Nov 27;76(10):1448-51 - PubMed
  23. Transplant Proc. 2007 Oct;39(8):2589-91 - PubMed
  24. Int J Cancer. 2010 Dec 15;127(12):2893-917 - PubMed
  25. Eur J Cancer. 2013 Jan;49(2):336-44 - PubMed
  26. JAMA. 2006 Dec 20;296(23):2823-31 - PubMed
  27. Nephrol Dial Transplant. 2002;17 Suppl 4:1-67 - PubMed
  28. Transplant Proc. 2002 Aug;34(5):1778-9 - PubMed
  29. Transplant Proc. 2003 Aug;35(5):1714-6 - PubMed
  30. Jpn J Clin Oncol. 2014 Feb;44(2):134-40 - PubMed

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