Display options
Cite
Islam MH, Ahmad IZ, Salman MT. Neuroprotective effects of Nigella sativa extracts during germination on central nervous system. Pharmacogn Mag. 2015;11:S182-9doi: 10.4103/0973-1296.157729.
Islam, M. H., Ahmad, I. Z., & Salman, M. T. (2015). Neuroprotective effects of Nigella sativa extracts during germination on central nervous system. Pharmacognosy magazine, 11S182-9. https://doi.org/10.4103/0973-1296.157729
Islam, Mohammad Hayatul, et al. "Neuroprotective effects of Nigella sativa extracts during germination on central nervous system." Pharmacognosy magazine vol. 11 (2015): S182-9. doi: https://doi.org/10.4103/0973-1296.157729
Islam MH, Ahmad IZ, Salman MT. Neuroprotective effects of Nigella sativa extracts during germination on central nervous system. Pharmacogn Mag. 2015 May;11:S182-9. doi: 10.4103/0973-1296.157729. PMID: 26109765; PMCID: PMC4461959.
Copy Download .nbib Format: NLM
Share it on

Pharmacogn Mag. 2015 May;11:S182-9. doi: 10.4103/0973-1296.157729.

Neuroprotective effects of Nigella sativa extracts during germination on central nervous system.

Pharmacognosy magazine

Mohammad Hayatul Islam, Iffat Zareen Ahmad, Mohammad Tariq Salman

Affiliations

  1. Department of Bioengineering, Integral University, Dasauli, Lucknow, Uttar Pradesh, India.
  2. Department of Pharmacology, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.

PMID: 26109765 PMCID: PMC4461959 DOI: 10.4103/0973-1296.157729

Abstract

BACKGROUND: Nigella sativa Linn. which has many acclaimed medicinal properties is an indigenous herbaceous plant and belongs to the Ranunculaceae family, which grows in countries bordering the Mediterranean Sea, Pakistan and India.

OBJECTIVE: This study was designed to investigate the effects of N. sativa seed extracts of different germination phases on the central nervous system (CNS) responses in experimental animals.

MATERIALS AND METHODS: Anxiolytic, locomotor activity of extracts (1 g/kg of body weight) was evaluated in both stressed and unstressed animal models and antiepileptic effect was evaluated by maximal electroshock seizure model keeping diazepam (20 mg/kg) as a positive control. Antidepressant effect was evaluated by forced swim test and tail suspension test keeping imipramine (15 mg/kg) as a positive control.

RESULTS: All tested extracts of N. sativa during different phases of germination (especially 5(th) day germination phase) showed significant (P < 0.001) anxiolytic effect in comparison to control. Diazepam reduced locomotor activity in control (unstressed) rats but did not show affect in stressed rats while N. sativa extracts from germination phases significantly (P < 0.001) reduced locomotor activity in unstressed as well as stressed animals. All the extracts of N. sativa from different germination phases exhibited significant (P < 0.001) reduction in various phases of epileptic seizure on comparison with the reference standard (diazepam). During antidepressant test, N. sativa extracts exhibited a slight reduction in the immobility of rats.

CONCLUSION: During germination, especially in 5(th) day germination extract, N. sativa showed significant CNS depressant activity as compared to whole seeds that possibly may be due higher content of secondary metabolites produced during germination.

Keywords: Antidepressant; Nigella sativa; anxiety; central nervous system; epilepsy; germination

References

  1. Emerg Med Clin North Am. 2000 Nov;18(4):637-54 - PubMed
  2. Biochem Pharmacol. 2005 Feb 15;69(4):595-602 - PubMed
  3. Lancet. 1997 May 24;349(9064):1498-504 - PubMed
  4. J Biomed Biotechnol. 2010;2010:398312 - PubMed
  5. Adv Exp Med Biol. 1981;133:221-30 - PubMed
  6. Psychopharmacology (Berl). 2007 Dec;195(2):183-92 - PubMed
  7. Pharmacol Rep. 2011;63(3):660-9 - PubMed
  8. J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):1-2 - PubMed
  9. Pak J Pharm Sci. 1998 Jan;11(1):9-14 - PubMed
  10. Nature. 1978 Aug 3;274(5670):512-3 - PubMed
  11. Zhongguo Yao Li Xue Bao. 1991 Sep;12(5):387-90 - PubMed
  12. Pharmacol Rep. 2007 May-Jun;59(3):284-90 - PubMed
  13. Brain Res. 2010 Sep 17;1352:167-75 - PubMed
  14. J Neurosci Methods. 1985 Aug;14(3):149-67 - PubMed
  15. Int J Health Sci (Qassim). 2008 Jan;2(1):15-25 - PubMed
  16. Indian J Pharm Sci. 2008 Nov;70(6):740-4 - PubMed
  17. Int Immunopharmacol. 2005 Dec;5(13-14):1749-70 - PubMed
  18. Pak J Pharm Sci. 2009 Apr;22(2):139-44 - PubMed
  19. Neuropsychopharmacology. 2002 Feb;26(2):155-63 - PubMed
  20. Br J Pharmacol. 1983 Jul;79(3):637-43 - PubMed
  21. Epilepsy Res. 2003 Sep;56(1):17-26 - PubMed
  22. J Ethnopharmacol. 2003 Sep;88(1):63-8 - PubMed
  23. Methods Find Exp Clin Pharmacol. 2006 Mar;28(2):95-9 - PubMed
  24. Am J Clin Nutr. 1985 Nov;42(5 Suppl):1072-82 - PubMed
  25. Brain Res. 1990 Dec 3;535(1):96-100 - PubMed
  26. Pharmacol Res. 1997 Nov;36(5):381-5 - PubMed
  27. Behav Brain Res. 1996;73(1-2):43-6 - PubMed
  28. Epidemiol Psichiatr Soc. 2006 Jan-Mar;15(1):4-10 - PubMed
  29. Pharmacol Rep. 2007 Nov-Dec;59(6):699-707 - PubMed
  30. Pharmacol Biochem Behav. 1988 Nov;31(3):541-6 - PubMed
  31. Pharm Res. 1984 Sep;1(5):229-31 - PubMed
  32. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1502-7 - PubMed
  33. J Neurosci. 2011 Aug 31;31(35):12543-53 - PubMed
  34. J Biochem. 2003 Apr;133(4):501-5 - PubMed
  35. Phytomedicine. 2007 Sep;14(9):621-7 - PubMed
  36. Indian J Exp Biol. 2010 Apr;48(4):365-72 - PubMed
  37. J Clin Psychiatry. 2003 Jun;64(6):654-62 - PubMed
  38. Psychopharmacology (Berl). 1993;112(1):13-20 - PubMed

Publication Types