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Ivanova J, Gluhcheva Y, Arpadjan S, et al. Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication. Interdiscip Toxicol. 2014;7(2):111-5doi: 10.2478/intox-2014-0015.
Ivanova, J., Gluhcheva, Y., Arpadjan, S., & Mitewa, M. (2014). Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication. Interdisciplinary toxicology, 7(2), 111-5. https://doi.org/10.2478/intox-2014-0015
Ivanova, Juliana, et al. "Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication." Interdisciplinary toxicology vol. 7,2 (2014): 111-5. doi: https://doi.org/10.2478/intox-2014-0015
Ivanova J, Gluhcheva Y, Arpadjan S, Mitewa M. Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication. Interdiscip Toxicol. 2014 Jun;7(2):111-5. doi: 10.2478/intox-2014-0015. Epub 2014 Nov 15. PMID: 26109887; PMCID: PMC4427723.
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Interdiscip Toxicol. 2014 Jun;7(2):111-5. doi: 10.2478/intox-2014-0015. Epub 2014 Nov 15.

Effects of cadmium and monensin on renal and cardiac functions of mice subjected to subacute cadmium intoxication.

Interdisciplinary toxicology

Juliana Ivanova, Yordanka Gluhcheva, Sonja Arpadjan, Mariana Mitewa

Affiliations

  1. Faculty of Medicine, Sofia University "St. Kl. Ohridski", Kozjak 1 Str., 1407 Sofia, Bulgaria.
  2. Institute of Experimental Morphology, Pathology and Anthropology with Museum, BAS, Acad. Georgi Bonchev Str., bl. 25, 1113 Sofia, Bulgaria.
  3. Faculty of Chemistry and Pharmacy, Sofia University, "St. Kl. Ohridski" J. Bourchier blvd 1, 1164 Sofia, Bulgaria.

PMID: 26109887 PMCID: PMC4427723 DOI: 10.2478/intox-2014-0015

Abstract

Cadmium (Cd) is a well-known nephrotoxic agent. Cd-induced renal dysfunction has been considered as one of the causes leading to the development of hypertension. The correlation between Cd concentration in blood and urine and cardiovascular diseases has been discussed in many epidemiological studies. A therapy with chelating agents is utilized for the treatment of toxic metal intoxication. Herein we present novel information indicating that monensin (applied as tetraethylammonium salt) is a promising chelating agent for the treatment of Cd-induced renal and cardiac dysfunction. The study was performed using the ICR mouse model. Adult ICR male mice were divided into three groups with six animals in each group: control (received distilled water and food ad libitum for 28 days); Cd-intoxicated (treated orally with 20 mg/kg b.w. Cd(II) acetate from day 1 to day 14 of the experimental protocol), and monensin treated group (intoxicated with Cd(II) acetate as described for the Cd-intoxicated group followed by oral treatment with 16 mg/kg b.w. tetraethylammonium salt of monensic acid for 2 weeks). Cd intoxication of the animals resulted in an increase of the organ weight/body weight indexes. Cd elevated significantly creatinine and glucose level in serum. Monensin treatment improved the organ weight/body weight ratios. The therapy of the Cd-intoxicated animals with monensin ameliorated the creatinine and glucose level in serum and decreased the concentration of the toxic metal ions in the heart and kidneys by 54% and 64%, respectively.

Keywords: Cadmium; cardiac function; chelating agents; in vivo model; monensin; renal function

References

  1. Wien Med Wochenschr. 1987 Dec 15;137(23):553-7 - PubMed
  2. Am J Epidemiol. 2010 Sep 15;172(6):671-81 - PubMed
  3. Toxicol Sci. 2008 Apr;102(2):207-18 - PubMed
  4. Toxicol Appl Pharmacol. 2009 Aug 1;238(3):289-93 - PubMed
  5. Curr Med Chem. 2005;12(23):2771-94 - PubMed
  6. Rev Med Interne. 2010 Feb;31(2):107-15 - PubMed
  7. Chem Biol Interact. 2008 Jul 30;174(2):88-97 - PubMed
  8. Environ Health Perspect. 2006 Apr;114(4):484-93 - PubMed
  9. Biometals. 2004 Oct;17(5):485-9 - PubMed
  10. Drug Chem Toxicol. 1982;5(3):305-17 - PubMed
  11. Environ Res. 2010 Feb;110(2):199-206 - PubMed
  12. Toxicol Lett. 2005 May 16;157(1):57-68 - PubMed
  13. Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):451-63 - PubMed
  14. Toxicol Appl Pharmacol. 1998 Mar;149(1):49-54 - PubMed
  15. Int J Environ Res Public Health. 2010 Jul;7(7):2745-88 - PubMed
  16. J Trace Elem Med Biol. 2012 Oct;26(4):279-84 - PubMed
  17. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1392-8 - PubMed
  18. Environ Health Perspect. 1994 Sep;102 Suppl 3:191-4 - PubMed
  19. N Engl J Med. 1999 Jan 14;340(2):115-26 - PubMed
  20. Toxicology. 2006 Oct 3;227(1-2):15-20 - PubMed
  21. Indian J Pharmacol. 2011 Feb;43(1):45-9 - PubMed
  22. Life Sci. 2006 Sep 13;79(16):1493-506 - PubMed
  23. Toxicology. 2007 Jan 5;229(1-2):145-56 - PubMed
  24. Biometals. 2011 Feb;24(1):105-15 - PubMed
  25. Toxicol Lett. 2010 Sep 15;198(1):77-82 - PubMed

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