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Acta Naturae. 2015 Apr-Jun;7(2):87-94.

Detection of T-Cadherin Expression in Mouse Embryos.

Acta naturae

K A Rubina, V A Smutova, M L Semenova, A A Poliakov, S Gerety, D Wilkinson, E I Surkova, E V Semina, V Yu Sysoeva, V A Tkachuk

Affiliations

  1. Department of Biochemistry and Molecular Medicine, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovskiy Prosp., 31/5, 119192, Moscow, Russia.
  2. Department of Embryology, Biology Faculty, Lomonosov Moscow State University, Leninskie Gory, 1/12, 119234, Moscow, Russia.
  3. Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
  4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

PMID: 26085949 PMCID: PMC4463417

Abstract

The aim of the present study was to evaluate T-cadherin expression at the early developmental stages of the mouse embryo. Using in situ hybridization and immunofluorescent staining of whole embryos in combination with confocal microscopy, we found that T-cadherin expression is detected in the developing brain, starting with the E8.75 stage, and in the heart, starting with the E11.5 stage. These data suggest a possible involvement of T-cadherin in the formation of blood vessels during embryogenesis.

Keywords: T-cadherin; angiogenesis; embryogenesis; in situ hybridization

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