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Dorajoo R, Liu J, Boehm BO. Genetics of Type 2 Diabetes and Clinical Utility. Genes (Basel). 2015;6(2):372-84doi: 10.3390/genes6020372.
Dorajoo, R., Liu, J., & Boehm, B. O. (2015). Genetics of Type 2 Diabetes and Clinical Utility. Genes, 6(2), 372-84. https://doi.org/10.3390/genes6020372
Dorajoo, Rajkumar, et al. "Genetics of Type 2 Diabetes and Clinical Utility." Genes vol. 6,2 (2015): 372-84. doi: https://doi.org/10.3390/genes6020372
Dorajoo R, Liu J, Boehm BO. Genetics of Type 2 Diabetes and Clinical Utility. Genes (Basel). 2015 Jun 23;6(2):372-84. doi: 10.3390/genes6020372. PMID: 26110315; PMCID: PMC4488669.
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Genes (Basel). 2015 Jun 23;6(2):372-84. doi: 10.3390/genes6020372.

Genetics of Type 2 Diabetes and Clinical Utility.

Genes

Rajkumar Dorajoo, Jianjun Liu, Bernhard O Boehm

Affiliations

  1. Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. [email protected].
  2. Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. [email protected].
  3. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore. [email protected].
  4. Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. [email protected].
  5. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. [email protected].
  6. Imperial College London, London, SW7 2AZ, UK. [email protected].
  7. Department of Endocrinology, Tan Tock Seng Hospital, Singapore 308433, Singapore. [email protected].

PMID: 26110315 PMCID: PMC4488669 DOI: 10.3390/genes6020372

Abstract

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting-for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions.

Keywords: clinical utility; genetics; type 2 diabetes

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