Display options
Cite
Reeves GC, Alhurani AS, Frazier SK, et al. The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure. BMJ Open Diabetes Res Care. 2015;3(1):e000077doi: 10.1136/bmjdrc-2014-000077.
Reeves, G. C., Alhurani, A. S., Frazier, S. K., Watkins, J. F., Lennie, T. A., & Moser, D. K. (2015). The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure. BMJ open diabetes research & care, 3(1), e000077. https://doi.org/10.1136/bmjdrc-2014-000077
Reeves, Geri C, et al. "The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure." BMJ open diabetes research & care vol. 3,1 (2015): e000077. doi: https://doi.org/10.1136/bmjdrc-2014-000077
Reeves GC, Alhurani AS, Frazier SK, Watkins JF, Lennie TA, Moser DK. The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure. BMJ Open Diabetes Res Care. 2015 May 30;3(1):e000077. doi: 10.1136/bmjdrc-2014-000077. eCollection 2015. PMID: 26056566; PMCID: PMC4452727.
Copy Download .nbib Format: NLM
Share it on

BMJ Open Diabetes Res Care. 2015 May 30;3(1):e000077. doi: 10.1136/bmjdrc-2014-000077. eCollection 2015.

The association of comorbid diabetes mellitus and symptoms of depression with all-cause mortality and cardiac rehospitalization in patients with heart failure.

BMJ open diabetes research & care

Geri C Reeves, Abdullah S Alhurani, Susan K Frazier, John F Watkins, Terry A Lennie, Debra K Moser

Affiliations

  1. Vanderbilt University , Tennessee , USA.
  2. University of Kentucky , Lexington , USA ; The University of Jordan , Amman , Jordan.
  3. University of Kentucky , Lexington , USA.
  4. University of Kentucky , Lexington , USA ; The University of Ulster , Newtownabbey , UK.

PMID: 26056566 PMCID: PMC4452727 DOI: 10.1136/bmjdrc-2014-000077

Abstract

BACKGROUND: More than 22% of individuals with diabetes mellitus have concomitant heart failure (HF), and the prevalence of diabetes in those with HF is nearly triple that of individuals without HF. Comorbid depressive symptoms are common in diabetes and HF. Depressive symptoms are an independent predictor of mortality in individuals with diabetes alone, as well as those with HF alone and are a predictor of rehospitalization in those with HF. However, the association of comorbid HF, diabetes and depressive symptoms with all-cause mortality and rehospitalization for cardiac causes has not been determined.

OBJECTIVE: The purpose of this study was to evaluate the association of comorbid HF, diabetes and depression with all-cause mortality and rehospitalization for cardiac cause.

METHOD: Patients provided data at baseline about demographic and clinical variables and depressive symptoms; patients were followed for at least 2 years. Participants were divided into four groups based on the presence and absence of diabetes and depressive symptoms. Cox regression analysis was used to determine whether comorbid diabetes and depressive symptoms independently predicted all-cause mortality and cardiac rehospitalization in these patients with HF.

RESULTS: Patients (n=663) were primarily male (69%), white (76%), and aged 61±13 years. All-cause mortality was independently predicted by the presence of concomitant diabetes and depressive symptoms (HR 3.71; 95% CI 1.49 to 9.25; p=0.005), and depressive symptoms alone (HR 2.29; 95% CI 0.94 to 5.40; p=0.05). The presence of comorbid diabetes and depressive symptoms was also an independent predictor of cardiac rehospitalization (HR 2.36; 95% CI 1.27 to 4.39; p=0.007).

CONCLUSIONS: Comorbid diabetes and depressive symptoms are associated with poorer survival and rehospitalization in patients with HF; effective strategies to regularly evaluate and effectively manage these comorbid conditions are necessary to improve survival and reduce rehospitalization rates.

Keywords: Heart Failure; Mortality; Type 1; Type 2 Diabetes

References

  1. J Cardiol. 2014 Dec;64(6):456-62 - PubMed
  2. J Affect Disord. 2012 Oct;142 Suppl:S8-21 - PubMed
  3. J Diabetes. 2015 Nov;7(6):864-71 - PubMed
  4. Cardiol Rev. 2006 Jul-Aug;14(4):164-9 - PubMed
  5. Circulation. 2001 Oct 23;104(17):2024-8 - PubMed
  6. Ann Behav Med. 2006 Oct;32(2):121-6 - PubMed
  7. Age Ageing. 2013 Sep;42(5):626-32 - PubMed
  8. Prev Med. 2014 Jun;63:36-42 - PubMed
  9. J Am Coll Cardiol. 2001 Aug;38(2):421-8 - PubMed
  10. JAMA. 1999 Nov 10;282(18):1737-44 - PubMed
  11. J Card Fail. 2004 Jun;10(3):258-71 - PubMed
  12. J Psychosom Res. 2014 Oct;77(4):296-301 - PubMed
  13. J Card Fail. 2011 Sep;17(9):755-63 - PubMed
  14. J Am Coll Cardiol. 2003 Sep 3;42(5):914-22 - PubMed
  15. Eur J Heart Fail. 2002 Aug;4(4):541-51 - PubMed
  16. Diabetes Care. 1999 Feb;22(2):233-40 - PubMed
  17. Int J Nurs Stud. 2009 Nov;46(11):1485-95 - PubMed
  18. Circulation. 2008 Oct 21;118(17):1768-75 - PubMed
  19. J Am Coll Cardiol. 2001 Jul;38(1):199-205 - PubMed
  20. Eur J Heart Fail. 2005 Mar 2;7(2):261-7 - PubMed
  21. Patient Prefer Adherence. 2015 Jan 28;9:191-7 - PubMed
  22. Med Sci Monit. 2004 Dec;10(12):CR643-8 - PubMed
  23. Am J Cardiol. 2005 Oct 15;96(8):1076-81 - PubMed
  24. BMC Health Serv Res. 2012 Nov 30;12:434 - PubMed
  25. Arch Intern Med. 2000 Nov 27;160(21):3278-85 - PubMed
  26. Arch Gen Psychiatry. 1998 Jul;55(7):580-92 - PubMed
  27. J Psychosom Res. 2000 Apr-May;48(4-5):493-500 - PubMed
  28. Arch Intern Med. 2001 Aug 13-27;161(15):1849-56 - PubMed
  29. Cardiol Clin. 2004 Nov;22(4):553-68 - PubMed
  30. J Card Fail. 2008 Apr;14(3):203-10 - PubMed
  31. J Gen Intern Med. 2007 Nov;22(11):1596-602 - PubMed
  32. Diabetes Care. 2003 Aug;26(8):2433-41 - PubMed
  33. Heart. 1998 Nov;80(5):437-41 - PubMed
  34. J Clin Epidemiol. 2004 Sep;57(9):978-84 - PubMed
  35. Heart Lung. 2014 Jul-Aug;43(4):299-305 - PubMed
  36. JACC Heart Fail. 2015 Feb;3(2):136-45 - PubMed
  37. Am J Cardiol. 2004 Dec 15;94(12):1577-80 - PubMed
  38. Circulation. 1996 Nov 1;94(9):2285-96 - PubMed

Publication Types

Grant support