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Bhargava S, Perlman DM, Allen TL, et al. Adalimumab induced pulmonary sarcoid reaction. Respir Med Case Rep. 2013;10:53-5doi: 10.1016/j.rmcr.2013.07.002.
Bhargava, S., Perlman, D. M., Allen, T. L., Ritter, J. H., & Bhargava, M. (2013). Adalimumab induced pulmonary sarcoid reaction. Respiratory medicine case reports, 1053-5. https://doi.org/10.1016/j.rmcr.2013.07.002
Bhargava, S, et al. "Adalimumab induced pulmonary sarcoid reaction." Respiratory medicine case reports vol. 10 (2013): 53-5. doi: https://doi.org/10.1016/j.rmcr.2013.07.002
Bhargava S, Perlman DM, Allen TL, Ritter JH, Bhargava M. Adalimumab induced pulmonary sarcoid reaction. Respir Med Case Rep. 2013 Oct 26;10:53-5. doi: 10.1016/j.rmcr.2013.07.002. eCollection 2013. PMID: 26029514; PMCID: PMC3920421.
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Respir Med Case Rep. 2013 Oct 26;10:53-5. doi: 10.1016/j.rmcr.2013.07.002. eCollection 2013.

Adalimumab induced pulmonary sarcoid reaction.

Respiratory medicine case reports

S Bhargava, D M Perlman, T L Allen, J H Ritter, M Bhargava

Affiliations

  1. Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
  2. Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
  3. Department of Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.

PMID: 26029514 PMCID: PMC3920421 DOI: 10.1016/j.rmcr.2013.07.002

Abstract

Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology. There is evidence that Tumor Necrosis Factor alpha (TNF-α) antagonists are useful in the treatment of advanced or refractory disease. However, sarcoidosis-like reaction has been reported with TNF-α blockade in other inflammatory conditions. Here we report a case of sarcoid-like reaction in a patient with psoriatic arthritis shortly after initiation of adalimumab therapy. Stopping adalimumab and systemic anti-inflammatory therapy with corticosteroids resulted in resolution of pulmonary symptoms and chest radiographic findings. Though TNF-α plays a critical role in pathogenesis of sarcoidosis, the development of sarcoid reaction with TNF-α blockade is paradoxical and the mechanism of this response remains unknown. TNF-α induced sarcoid-reaction could involve multiple organs. Its development with one agent does not preclude therapy with other TNF-α blockers.

Keywords: Adalimumab; Sarcoid reaction; TNF blockers

References

  1. J Rheumatol. 2009 Dec;36(12):2847-8 - PubMed
  2. J Dermatol. 2010 May;37(5):471-4 - PubMed
  3. Eur Respir J. 2008 Jun;31(6):1189-96 - PubMed
  4. J Drugs Dermatol. 2012 May;11(5):609-12 - PubMed
  5. Am J Respir Crit Care Med. 2006 Oct 1;174(7):795-802 - PubMed
  6. Am J Respir Crit Care Med. 2004 Dec 15;170(12):1324-30 - PubMed
  7. N Engl J Med. 2007 Nov 22;357(21):2153-65 - PubMed
  8. Sarcoidosis Vasc Diffuse Lung Dis. 2006 Oct;23(3):201-8 - PubMed
  9. J Rheumatol. 2004 Oct;31(10):1955-8 - PubMed
  10. Bull NYU Hosp Jt Dis. 2012;70(3):167-71 - PubMed
  11. Clin Infect Dis. 2005 Aug 1;41 Suppl 3:S199-203 - PubMed
  12. J Intern Med. 2003 Jan;253(1):18-30 - PubMed
  13. Ann Rheum Dis. 2008 Jun;67(6):896-8 - PubMed
  14. Am J Clin Dermatol. 2008;9(1):1-14 - PubMed
  15. Australas J Dermatol. 2011 Aug;52(3):e8-11 - PubMed
  16. Arthritis Rheum. 2003 Jul;48(7):2077-8 - PubMed
  17. Int J Dermatol. 2011 May;50(5):619-25 - PubMed
  18. Dermatology. 2010;220(3):234-7 - PubMed
  19. J Clin Rheumatol. 2010 Sep;16(6):274-9 - PubMed
  20. Chest. 2003 Jul;124(1):177-85 - PubMed
  21. Clin Rheumatol. 2003 Feb;22(1):56-61 - PubMed
  22. Semin Arthritis Rheum. 2005 Apr;34(5 Suppl1):34-8 - PubMed
  23. Curr Rheumatol Rep. 2008 Dec;10(6):442-8 - PubMed
  24. Intern Med J. 2012 Jan;42(1):89-94 - PubMed
  25. J Eur Acad Dermatol Venereol. 2007 Apr;21(4):550-2 - PubMed
  26. Eur Respir J. 2000 Oct;16(4):768-80 - PubMed
  27. J Rheumatol. 2008 Nov;35(11):2279-82 - PubMed
  28. BioDrugs. 2003;17(6):425-31 - PubMed
  29. Rheumatology (Oxford). 2009 Aug;48(8):883-6 - PubMed
  30. Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):32-46 - PubMed
  31. J Med Econ. 2013;16(4):479-89 - PubMed
  32. Semin Arthritis Rheum. 2005 Apr;34(5 Suppl1):7-11 - PubMed
  33. Arch Bronconeumol. 2011 Apr;47(4):208-12 - PubMed
  34. J Rheumatol Suppl. 2005 Jan;72:46-7 - PubMed

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