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Respir Med Case Rep. 2014 Mar 15;12:13-5. doi: 10.1016/j.rmcr.2013.12.007. eCollection 2014.

Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae.

Respiratory medicine case reports

Masafumi Seki, Hisao Yoshida, Kazuyoshi Gotoh, Nobuyuki Hamada, Daisuke Motooka, Shota Nakamura, Norihisa Yamamoto, Shigeto Hamaguchi, Yukihiro Akeda, Hiroshi Watanabe, Tetsuya Iida, Kazunori Tomono

Affiliations

  1. Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.
  2. Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita City, Osaka, Japan.
  3. Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Kurume, Japan.
  4. Laboratory for Clinical of Clinical Research on Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita City, Osaka, Japan.

PMID: 26029528 PMCID: PMC4061431 DOI: 10.1016/j.rmcr.2013.12.007

Abstract

A 64-year-old male patient was admitted with respiratory failure, although chest X-rays revealed only mild bronchiolitis. Streptococcus pneumoniae, which usually presents as massive lobular pneumonia, was isolated from sputum, however, pan-pathogen screening using a next-generation sequencer also detected human metapneumovirus genome fragments.

Keywords: Co-infection; Human metapneumovirus; Next-generation sequencer; Real-time PCR; Streptococcus pneumoniae

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