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Bendstrup E, Hyldgaard C, Agerbæk M, et al. No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis. Respir Med Case Rep. 2014;12:47-9doi: 10.1016/j.rmcr.2013.12.010.
Bendstrup, E., Hyldgaard, C., Agerbæk, M., Andersen, C. U., & Hilberg, O. (2014). No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis. Respiratory medicine case reports, 1247-9. https://doi.org/10.1016/j.rmcr.2013.12.010
Bendstrup, Elisabeth, et al. "No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis." Respiratory medicine case reports vol. 12 (2014): 47-9. doi: https://doi.org/10.1016/j.rmcr.2013.12.010
Bendstrup E, Hyldgaard C, Agerbæk M, Andersen CU, Hilberg O. No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis. Respir Med Case Rep. 2014 May 02;12:47-9. doi: 10.1016/j.rmcr.2013.12.010. eCollection 2014. PMID: 26029540; PMCID: PMC4061441.
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Respir Med Case Rep. 2014 May 02;12:47-9. doi: 10.1016/j.rmcr.2013.12.010. eCollection 2014.

No effect of pirfenidone treatment in fulminant bleomycin-induced pneumonitis.

Respiratory medicine case reports

Elisabeth Bendstrup, Charlotte Hyldgaard, Mads Agerbæk, Charlotte U Andersen, Ole Hilberg

Affiliations

  1. Department of Respiratory Medicine and Allergology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.
  2. Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.
  3. Department of Clinical Pharmacology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

PMID: 26029540 PMCID: PMC4061441 DOI: 10.1016/j.rmcr.2013.12.010

Abstract

Bleomycin-induced pneumonitis (BIP) is a serious and potentially fatal adverse effect of bleomycin. Currently, BIP is treated on an empirical basis with high dose steroid. Pirfenidone is a new antifibrotic drug, which has been proven beneficial in idiopathic pulmonary fibrosis and is able to inhibit or reverse BIP in animal models. Here, the first two cases of human BIP treated with pirfenidone in addition to steroid therapy are presented. Unfortunately, both patients died, which may be explained by the initiation of therapy at a late stage. Therefore, studies of early or prophylactic treatment with pirfenidone in relation to bleomycin-containing chemotherapy regimens are needed.

Keywords: Bleomycin; Pirfenidone; Pneumonitis

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