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Nei T, Okabe M, Mikami I, et al. A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-γ. Respir Med Case Rep. 2012;8:10-3doi: 10.1016/j.rmcr.2012.11.003.
Nei, T., Okabe, M., Mikami, I., Koizumi, Y., Mase, H., Matsuda, K., Yamamoto, T., Takeda, S., Tanaka, K., & Dan, K. (2013). A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-γ. Respiratory medicine case reports, 810-3. https://doi.org/10.1016/j.rmcr.2012.11.003
Nei, Takahito, et al. "A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-γ." Respiratory medicine case reports vol. 8 (2013): 10-3. doi: https://doi.org/10.1016/j.rmcr.2012.11.003
Nei T, Okabe M, Mikami I, Koizumi Y, Mase H, Matsuda K, Yamamoto T, Takeda S, Tanaka K, Dan K. A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-γ. Respir Med Case Rep. 2012 Dec 31;8:10-3. doi: 10.1016/j.rmcr.2012.11.003. eCollection 2013. PMID: 26029606; PMCID: PMC3920570.
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Respir Med Case Rep. 2012 Dec 31;8:10-3. doi: 10.1016/j.rmcr.2012.11.003. eCollection 2013.

A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-γ.

Respiratory medicine case reports

Takahito Nei, Masahiro Okabe, Iwao Mikami, Yumika Koizumi, Hiroshi Mase, Kuniko Matsuda, Takeshi Yamamoto, Shinhiro Takeda, Keiji Tanaka, Kazuo Dan

Affiliations

  1. Division of Intensive Care and Cardiac Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan ; Department of Internal Medicine, Division of Respiratory Medicine, Infection and Oncology, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  2. Department of Internal Medicine, Division of Hematology, Gastroenterology and Endocrinology and Metabolism, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  3. Department of Surgery, Division of Thoracic Surgery, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  4. Division of Intensive Care and Cardiac Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
  5. Department of Internal Medicine, Division of Respiratory Medicine, Infection and Oncology, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

PMID: 26029606 PMCID: PMC3920570 DOI: 10.1016/j.rmcr.2012.11.003

Abstract

Disseminated non-tuberculous mycobacterium (dNTM) infection is rare in humans without human immunodeficiency virus (HIV) infection. Previous reports have shown autoantibodies to human interferon-gamma (IFN-γ), which play important roles in mycobacterium infection, in the sera of patients with non-HIV dNTM disease. Herein, we describe a 53-year-old male who was strongly suspected to have multicentric Castleman disease (MCD) based on bone marrow study and chest radiological findings. However, Mycobacterium kansasii was detected in respiratory samples including pleural effusion. We initiated anti-mycobacterial therapy under intensive care; he died on the 48(th) hospital day. We detected no hematological disorders, ruling out MCD postmortem. However, we detected M. kansasii in pulmonary, liver, spleen and bone marrow tissues. Moreover, anti-IFN-γ autoantibody was detected with strong neutralizing capacity for IFN-γ. We consider our present report to contribute to understanding of the relationship between anti-IFN-γ autoantibody and disease development.

Keywords: Anti-IFN-γ autoantibody; Disseminated non-tuberculous mycobacterium disease; Non-HIV patient

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