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Sverzellati N, Lynch DA, Pistolesi M, et al. PHYSIOLOGIC AND QUANTITATIVE COMPUTED TOMOGRAPHY DIFFERENCES BETWEEN CENTRILOBULAR AND PANLOBULAR EMPHYSEMA IN COPD. Chronic Obstr Pulm Dis. 2014;1(1):125-132doi: 10.15326/jcopdf.1.1.2014.0114.
Sverzellati, N., Lynch, D. A., Pistolesi, M., Kauczor, H. U., Grenier, P. A., Wilson, C., & Crapo, J. D. (2014). PHYSIOLOGIC AND QUANTITATIVE COMPUTED TOMOGRAPHY DIFFERENCES BETWEEN CENTRILOBULAR AND PANLOBULAR EMPHYSEMA IN COPD. Chronic obstructive pulmonary diseases (Miami, Fla.), 1(1), 125-132. https://doi.org/10.15326/jcopdf.1.1.2014.0114
Sverzellati, Nicola, et al. "PHYSIOLOGIC AND QUANTITATIVE COMPUTED TOMOGRAPHY DIFFERENCES BETWEEN CENTRILOBULAR AND PANLOBULAR EMPHYSEMA IN COPD." Chronic obstructive pulmonary diseases (Miami, Fla.) vol. 1,1 (2014): 125-132. doi: https://doi.org/10.15326/jcopdf.1.1.2014.0114
Sverzellati N, Lynch DA, Pistolesi M, Kauczor HU, Grenier PA, Wilson C, Crapo JD. PHYSIOLOGIC AND QUANTITATIVE COMPUTED TOMOGRAPHY DIFFERENCES BETWEEN CENTRILOBULAR AND PANLOBULAR EMPHYSEMA IN COPD. Chronic Obstr Pulm Dis. 2014;1(1):125-132. doi: 10.15326/jcopdf.1.1.2014.0114. PMID: 26029738; PMCID: PMC4447143.
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Chronic Obstr Pulm Dis. 2014;1(1):125-132. doi: 10.15326/jcopdf.1.1.2014.0114.

PHYSIOLOGIC AND QUANTITATIVE COMPUTED TOMOGRAPHY DIFFERENCES BETWEEN CENTRILOBULAR AND PANLOBULAR EMPHYSEMA IN COPD.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Nicola Sverzellati, David A Lynch, Massimo Pistolesi, Hans-Ulrich Kauczor, P A Grenier, C Wilson, J D Crapo

Affiliations

  1. Department of Surgery, Section of Diagnostic Imaging, University of Parma, Parma, Italy.
  2. Division of Radiology, National Jewish Health, Denver, USA.
  3. Section of Respiratory Medicine, Department of Internal Medicine, University of Florence, Italy.
  4. Diagnostic and Interventional Radiology, University Clinic Heidelberg, Germany.
  5. Service de Radiologie Polyvalente, Diagnostique and Interventionelle, Hospital Pitie-Salpetriere, Paris, France.
  6. Division of Biostatistics and Bioinformatics, National Jewisj Health, Denver, Denver, USA.
  7. Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, USA.

PMID: 26029738 PMCID: PMC4447143 DOI: 10.15326/jcopdf.1.1.2014.0114

Abstract

BACKGROUND: The purpose was to define the differences between centrilobular (CLE) and panlobular emphysema (PLE) phenotypes in cigarette smokers with COPD by a combined qualitative-quantitative computed tomography (CT) analysis.

METHODS: Chest CT scans of 116 cigarette smokers were visually scored by 22 chest radiologists and 29 pulmonologists in a single setting for the predominant emphysema phenotype (e.g. CLE or PLE) and automatically quantified for emphysema{% low attenuation area (LAA) ≤ -950 HU - %LAA

RESULTS: Although more frequent than CLE in GOLD stages 3 and 4 (p = 0.01), PLE was also scored in 38.2% of combined GOLD stages 1 and 2. PLE was positively associated with %LAA

CONCLUSIONS: PLE likely represents a more advanced phase of emphysema, which may also occur in earlier COPD stages and show different interplay with airway disease as compared to CLE.

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