Display options
Cite
Zhu TC, Liang X, Kim MM, et al. An IR Navigation System for Pleural PDT. Front Phys. 2015;3doi: 10.3389/fphy.2015.00009.
Zhu, T. C., Liang, X., Kim, M. M., Finlay, J. C., Dimofte, A., Rodriguez, C., Simone, C. B., Friedberg, J. S., & Cengel, K. A. (2015). An IR Navigation System for Pleural PDT. Frontiers in physics, 3. https://doi.org/10.3389/fphy.2015.00009
Zhu, Timothy C, et al. "An IR Navigation System for Pleural PDT." Frontiers in physics vol. 3 (2015). doi: https://doi.org/10.3389/fphy.2015.00009
Zhu TC, Liang X, Kim MM, Finlay JC, Dimofte A, Rodriguez C, Simone CB, Friedberg JS, Cengel KA. An IR Navigation System for Pleural PDT. Front Phys. 2015 Mar;3. doi: 10.3389/fphy.2015.00009. PMID: 25995987; PMCID: PMC4435962.
Copy Download .nbib Format: NLM
Share it on

Front Phys. 2015 Mar;3. doi: 10.3389/fphy.2015.00009.

An IR Navigation System for Pleural PDT.

Frontiers in physics

Timothy C Zhu, Xing Liang, Michele M Kim, Jarod C Finlay, Andreea Dimofte, Carmen Rodriguez, Charles B Simone, Joseph S Friedberg, Keith A Cengel

Affiliations

  1. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

PMID: 25995987 PMCID: PMC4435962 DOI: 10.3389/fphy.2015.00009

Abstract

Pleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for malignant pleural mesothelioma (MPM). In the current pleural PDT protocol, a moving fiber-based point source is used to deliver the light. The light fluences at multiple locations are monitored by several isotropic detectors placed in the pleural cavity. To improve the delivery of light fluence uniformity, an infrared (IR) navigation system is used to track the motion of the light source in real-time at a rate of 20 - 60 Hz. A treatment planning system uses the laser source positions obtained from the IR camera to calculate light fluence distribution to monitor the light fluence uniformity on the surface of the pleural cavity. A novel reconstruction algorithm is used to determine the pleural cavity surface contour. A dual-correction method is used to match the calculated fluences at detector locations to the detector readings. Preliminary data from a phantom shows superior light uniformity using this method. Light fluence uniformity from patient treatments is also shown with and without the correction method.

Keywords: Infrared camera; PDT; Pleural; navigation system

References

  1. Ann Thorac Surg. 1998 Oct;66(4):1128-33 - PubMed
  2. Ann Thorac Surg. 2012 May;93(5):1658-65; discussion 1665-7 - PubMed
  3. Comput Aided Surg. 2003;8(5):247-56 - PubMed
  4. Radiat Res. 1991 Jun;126(3):296-303 - PubMed
  5. Proc SPIE Int Soc Opt Eng. 2011 Feb 28;7886:null - PubMed
  6. J Urol. 2009 Feb;181(2):783-9; discussion 789-90 - PubMed
  7. Chest. 2001 Oct;120(4):1167-74 - PubMed
  8. Ann Surg Oncol. 1997 Dec;4(8):628-33 - PubMed
  9. Ann Thorac Surg. 2011 Jun;91(6):1738-45 - PubMed
  10. Proc SPIE Int Soc Opt Eng. 2009 Jan 24;7164:null - PubMed
  11. Neurosurg Focus. 2001 Dec 15;11(6):e5 - PubMed
  12. Photochem Photobiol. 1998 Sep;68(3):394-9 - PubMed
  13. Lancet Oncol. 2000 Dec;1:212-9 - PubMed
  14. Semin Thorac Cardiovasc Surg. 2009 Summer;21(2):172-6 - PubMed
  15. Proc SPIE Int Soc Opt Eng. 2010 Mar 4;7551:null - PubMed
  16. Lancet Oncol. 2004 Aug;5(8):497-508 - PubMed
  17. Photochem Photobiol. 1990 Aug;52(2):375-85 - PubMed
  18. Proc SPIE Int Soc Opt Eng. 2010 Mar 2;7551:null - PubMed
  19. J Natl Cancer Inst. 1998 Jun 17;90(12):889-905 - PubMed
  20. Photochem Photobiol. 1990 Mar;51(3):343-9 - PubMed
  21. Biomed Opt Express. 2011 Apr 15;2(5):1233-42 - PubMed
  22. J Clin Oncol. 2004 Jun 1;22(11):2192-201 - PubMed
  23. Photochem Photobiol. 1992 Jan;55(1):145-57 - PubMed
  24. Med Biol Eng Comput. 2006 Dec;44(12):1127-34 - PubMed

Publication Types

Grant support