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Santoro ML, Gadelha A, Ota VK, et al. Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls. World J Biol Psychiatry. 2015;16(6):441-446doi: 10.3109/15622975.2015.1048724.
Santoro, M. L., Gadelha, A., Ota, V. K., Cunha, G. R., Asevedo, E., Noto, C. S., Spindola, L. M., Pan, P. M., Talarico, F., Mansur, R. B., Silva, P. N., Brietzke, E., Cordeiro, Q., Bressan, R. A., & Belangero, S. I. (2015). Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 16(6), 441-446. https://doi.org/10.3109/15622975.2015.1048724
Santoro, Marcos Leite, et al. "Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls." The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry vol. 16,6 (2015): 441-446. doi: https://doi.org/10.3109/15622975.2015.1048724
Santoro ML, Gadelha A, Ota VK, Cunha GR, Asevedo E, Noto CS, Spindola LM, Pan PM, Talarico F, Mansur RB, Silva PN, Brietzke E, Cordeiro Q, Bressan RA, Belangero SI. Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls. World J Biol Psychiatry. 2015 Sep;16(6):441-446. doi: 10.3109/15622975.2015.1048724. Epub 2015 Jun 18. PMID: 26089098.
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World J Biol Psychiatry. 2015 Sep;16(6):441-446. doi: 10.3109/15622975.2015.1048724. Epub 2015 Jun 18.

Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Marcos Leite Santoro, Ary Gadelha, Vanessa K Ota, Graccielle R Cunha, Elson Asevedo, Cristiano S Noto, Leticia M Spindola, Pedro M Pan, Fernanda Talarico, Rodrigo B Mansur, Patricia N Silva, Elisa Brietzke, Quirino Cordeiro, Rodrigo A Bressan, Sintia Iole Belangero

Affiliations

  1. a Genetics Division, Department of Morphology and Genetics , Universidade Federal de Sao Paulo (UNIFESP) , São Paulo , Brazil.
  2. b LiNC - Interdisciplinary Laboratory of Clinical Neurosciences, UNIFESP , São Paulo , Brazil.
  3. c PRISMA - Program of Recognition and Intervention in subjects At-Risk Mental States, UNIFESP , São Paulo , Brazil.
  4. d Department of Psychiatry , Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP) , São Paulo , Brazil.

PMID: 26089098 DOI: 10.3109/15622975.2015.1048724

Abstract

OBJECTIVES: This study aimed to investigate peripheral blood gene expression in ultra-high-risk subjects (UHR) compared to first-episode psychosis individuals (FEP) and healthy controls (HC).

METHODS: We enrolled 22 UHR, 66 FEP and 67 HC and investigated the expression of 12 genes using Taqman assays. We used the Univariate General Linear Model, as well as Bonferroni correction for multiple comparisons.

RESULTS: We found that UFD1L (ubiquitin fusion degradation 1 like (yeast)) gene was upregulated in UHR group compared to HC and FEP (P = 3.44 × 10

CONCLUSIONS: These genes are directly related to neurodevelopmental processes and have been associated to schizophrenia. Recent findings described that DISC1 overexpression can disrupt MBP expression, thus, we think that these alterations in UHR individuals could be associated with a common process. UFD1L showed a different pattern of expression only for UHR group, suggesting that they can be under an acute endoplasmatic reticulum stress, demanding elevated levels of Ufd1. Further studies can improve knowledge on disease progression and putative targets to preventive strategies.

Keywords: DISC1; MBP; UFD1L; gene expression; schizophrenia

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