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Rohini K, Bhat S, Srikumar PS, et al. Serum PCT and its Relation to Body Weight Gain in Pulmonary Tuberculosis. Indian J Clin Biochem. 2014;30(3):329-33doi: 10.1007/s12291-014-0432-6.
Rohini, K., Bhat, S., Srikumar, P. S., & Mahesh Kumar, A. (2015). Serum PCT and its Relation to Body Weight Gain in Pulmonary Tuberculosis. Indian journal of clinical biochemistry : IJCB, 30(3), 329-33. https://doi.org/10.1007/s12291-014-0432-6
Rohini, K, et al. "Serum PCT and its Relation to Body Weight Gain in Pulmonary Tuberculosis." Indian journal of clinical biochemistry : IJCB vol. 30,3 (2015): 329-33. doi: https://doi.org/10.1007/s12291-014-0432-6
Rohini K, Bhat S, Srikumar PS, Mahesh Kumar A. Serum PCT and its Relation to Body Weight Gain in Pulmonary Tuberculosis. Indian J Clin Biochem. 2015 Jul;30(3):329-33. doi: 10.1007/s12291-014-0432-6. Epub 2014 Apr 18. PMID: 26089621; PMCID: PMC4469052.
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Indian J Clin Biochem. 2015 Jul;30(3):329-33. doi: 10.1007/s12291-014-0432-6. Epub 2014 Apr 18.

Serum PCT and its Relation to Body Weight Gain in Pulmonary Tuberculosis.

Indian journal of clinical biochemistry : IJCB

K Rohini, Surekha Bhat, P S Srikumar, A Mahesh Kumar

Affiliations

  1. Unit of Biochemistry, Faculty of Medicine, AIMST University, Semeling, 08100 Bedong, Malaysia.
  2. MSU-GEF International Medical School, Bangalore, India.
  3. Unit of Psychiatry, Faculty of Medicine, AIMST University, Bedong, Malaysia.
  4. Madras Medical Mission Hospital, Chennai, India.

PMID: 26089621 PMCID: PMC4469052 DOI: 10.1007/s12291-014-0432-6

Abstract

The present study was aimed at assessing alterations in serum PCT in terms of its relation to body weight gain in pulmonary tuberculosis (PTB) patients undergoing treatment. Among patients (25-75 years) diagnosed with pulmonary tuberculosis, those that were new smear positive, showed sputum conversion at the end of 2 months and were declared clinically cured at the end of 6 months, were included in the study (n = 40). Serum procalcitonin was determined by BRAHMS PCT-Q kit. Patients were divided into two study groups-Group 1 (n = 21; serum PCT > 2 ng/ml at diagnosis), Group 2 (n = 19; serum PCT > 10 ng/ml at diagnosis). Body weights of all patients were obtained at three different time points, PTB-0 (at diagnosis), PTB-2 (after 2 months of intensive treatment) and PTB-6 (after 6 months of treatment). In both groups, mean body weights at PTB-2 and PTB-6 were significantly higher than those at PTB-0 and at PTB-6 were significantly higher than those at PTB-2. However, percentage body weight gain following 2 months of intensive treatment was higher in group 1 (4.05 % gain, p < 0.01) than in group 2 (2.75 % body weight gain, p < 0.05). Thus, the percentage gain in group 1 was tending more towards the desirable minimum gain of 5 % during intensive phase. Increase in serum PCT levels in pulmonary tuberculosis is inversely associated with body weight gain during treatment. Thus, PCT could play a role in regulation of body weight gain in anorectic conditions like tuberculosis.

Keywords: Body weight; Chemotherapy; Malnutrition; Procalcitonin; Tuberculosis

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