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Silva AP, Gundlach K, Büchel J, et al. Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. Int J Endocrinol. 2015;2015:308190doi: 10.1155/2015/308190.
Silva, A. P., Gundlach, K., Büchel, J., Jerónimo, T., Fragoso, A., Silva, C., Guilherme, P., Santos, N., Faísca, M., & Neves, P. (2015). Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. International journal of endocrinology, 2015308190. https://doi.org/10.1155/2015/308190
Silva, Ana Paula, et al. "Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients." International journal of endocrinology vol. 2015 (2015): 308190. doi: https://doi.org/10.1155/2015/308190
Silva AP, Gundlach K, Büchel J, Jerónimo T, Fragoso A, Silva C, Guilherme P, Santos N, Faísca M, Neves P. Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients. Int J Endocrinol. 2015;2015:308190. doi: 10.1155/2015/308190. Epub 2015 May 18. PMID: 26089881; PMCID: PMC4451161.
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Int J Endocrinol. 2015;2015:308190. doi: 10.1155/2015/308190. Epub 2015 May 18.

Low Magnesium Levels and FGF-23 Dysregulation Predict Mitral Valve Calcification as well as Intima Media Thickness in Predialysis Diabetic Patients.

International journal of endocrinology

Ana Paula Silva, Kristina Gundlach, Janine Büchel, Teresa Jerónimo, André Fragoso, Claudia Silva, Patrícia Guilherme, Nélio Santos, Marília Faísca, Pedro Neves

Affiliations

  1. Nephrology, Hospital de Faro, Rua Leão Penedo, 8000-386 Faro, Portugal.
  2. Fresenius Medical Care Deutschland GmbH, 61352 Bad Homburg, Germany.
  3. Pathology Clinic, Hospital de Faro, 8000-386 Faro, Portugal.
  4. Cardiology, Hospital de Faro, 8000-386 Faro, Portugal.
  5. Pharmacology, Gnostic Laboratory, 8000-386 Faro, Portugal.

PMID: 26089881 PMCID: PMC4451161 DOI: 10.1155/2015/308190

Abstract

Background. Mitral valve calcification and intima media thickness (IMT) are common complications of chronic kidney disease (CKD) implicated with high cardiovascular mortality. Objective. To investigate the implication of magnesium and fibroblast growth factor-23 (FGF-23) levels with mitral valve calcification and IMT in CKD diabetic patients. Methods. Observational, prospective study involving 150 diabetic patients with mild to moderate CKD, divided according to Wilkins Score. Carotid-echodoppler and transthoracic echocardiography were used to assess calcification. Statistical tests used to establish comparisons between groups, to identify risk factors, and to establish cut-off points for prediction of mitral valve calcification. Results. FGF-23 values continually increased with higher values for both IMT and calcification whereas the opposite trend was observed for magnesium. FGF-23 and magnesium were found to independently predict mitral valve calcification and IMT (P < 0.05). Using Kaplan-Meier analysis, the number of deaths was higher in patients with lower magnesium levels and poorer Wilkins score. The mean cut-off value for FGF-23 was 117 RU/mL and for magnesium 1.7 mg/dL. Conclusions. Hypomagnesemia and high FGF-23 levels are independent predictors of mitral valve calcification and IMT and are risk factors for cardiovascular mortality in this population. They might be used as diagnostic/therapeutic targets in order to better manage the high cardiovascular risk in CKD patients.

References

  1. Am J Nephrol. 2012;36(3):228-37 - PubMed
  2. Biomed Pharmacother. 2003 Mar;57(2):88-97 - PubMed
  3. Magnes Res. 2013 Jul-Sep;26(3):100-8 - PubMed
  4. Int J Nephrol. 2010 Dec 30;2010:167984 - PubMed
  5. Hypertension. 2009 Mar;53(3):524-31 - PubMed
  6. J Am Soc Hypertens. 2013 Sep-Oct;7(5):344-52 - PubMed
  7. Hypertension. 2010 Sep;56(3):453-62 - PubMed
  8. J Am Soc Nephrol. 2001 Nov;12(11):2511-6 - PubMed
  9. Nephrol Dial Transplant. 2010 Dec;25(12):3983-9 - PubMed
  10. Ann Intern Med. 1999 Mar 16;130(6):461-70 - PubMed
  11. Am J Kidney Dis. 1998 Nov;32(5 Suppl 3):S112-9 - PubMed
  12. J Am Soc Nephrol. 2011 Oct;22(10):1913-22 - PubMed
  13. Clin Kidney J. 2014 Apr;7(2):161-6 - PubMed
  14. Magnes Res. 2004 Jun;17(2):102-8 - PubMed
  15. Nephrol Dial Transplant. 2011 Aug;26(8):2433-8 - PubMed
  16. J Am Soc Nephrol. 2001 Oct;12(10):2131-8 - PubMed
  17. Kidney Int. 1987 Sep;32(3):388-94 - PubMed
  18. Diabetes Care. 2010 Jan;33 Suppl 1:S62-9 - PubMed
  19. Curr Cardiovasc Imaging Rep. 2011 Oct;4(5):370-377 - PubMed
  20. Nephrology (Carlton). 2012 Jul;17(5):433-44 - PubMed
  21. Am J Med. 2013 Sep;126(9):825-31 - PubMed
  22. Kidney Int. 2014 Jan;85(1):174-81 - PubMed
  23. Clin Nephrol. 2007 Oct;68(4):222-7 - PubMed
  24. Magnes Res. 2007 Dec;20(4):237-44 - PubMed
  25. Nephrol Dial Transplant. 2005 Jul;20(7):1295-8 - PubMed
  26. Nephrol Dial Transplant. 1997 Sep;12(9):2036-7 - PubMed
  27. Circ Res. 2004 Sep 17;95(6):560-7 - PubMed
  28. Nephrol Dial Transplant. 2011 May;26(5):1662-9 - PubMed
  29. J Bone Miner Res. 2010 Oct;25(10):2091-7 - PubMed
  30. Int J Nephrol. 2011;2011:364890 - PubMed
  31. Hemodial Int. 2009 Oct;13(4):453-9 - PubMed
  32. Lab Anim. 1998 Oct;32(4):483-91 - PubMed
  33. Nat Rev Nephrol. 2014 May;10(5):268-78 - PubMed
  34. Am J Hypertens. 2010 Dec;23 (12 ):1292-8 - PubMed
  35. Nephrol Dial Transplant. 2003 Sep;18(9):1731-40 - PubMed
  36. J Am Soc Nephrol. 2005 Jul;16(7):2205-15 - PubMed
  37. Clin Kidney J. 2012 Feb;5(Suppl 1):i52-i61 - PubMed
  38. Nefrologia. 2013;33(3):389-99 - PubMed
  39. J Am Soc Echocardiogr. 2008 Feb;21(2):93-111; quiz 189-90 - PubMed
  40. Int J Hypertens. 2014;2014:381082 - PubMed
  41. Int J Hypertens. 2012;2012:754250 - PubMed
  42. Clin J Am Soc Nephrol. 2007 Mar;2(2):366-73 - PubMed
  43. World J Nephrol. 2012 Apr 6;1(2):43-53 - PubMed
  44. J Mol Med (Berl). 2010 May;88(5):467-75 - PubMed
  45. J Am Soc Nephrol. 2004 Aug;15(8):2208-18 - PubMed
  46. Nephrol Dial Transplant. 2010 Aug;25(8):2679-85 - PubMed
  47. Atherosclerosis. 2011 Nov;219(1):280-4 - PubMed
  48. J Am Coll Nutr. 2006 Jun;25(3):210-5 - PubMed
  49. Int Urol Nephrol. 2008;40(4):1075-82 - PubMed

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