Display options
Cite
Ljubic S, Jazbec A, Tomic M, et al. Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria. Int J Endocrinol. 2015;2015:372796doi: 10.1155/2015/372796.
Ljubic, S., Jazbec, A., Tomic, M., Piljac, A., Jurisic Erzen, D., Novak, B., Kastelan, S., Lovrencic, M. V., & Brkljacic, N. (2015). Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria. International journal of endocrinology, 2015372796. https://doi.org/10.1155/2015/372796
Ljubic, Spomenka, et al. "Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria." International journal of endocrinology vol. 2015 (2015): 372796. doi: https://doi.org/10.1155/2015/372796
Ljubic S, Jazbec A, Tomic M, Piljac A, Jurisic Erzen D, Novak B, Kastelan S, Lovrencic MV, Brkljacic N. Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria. Int J Endocrinol. 2015;2015:372796. doi: 10.1155/2015/372796. Epub 2015 May 18. PMID: 26089882; PMCID: PMC4451160.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol. 2015;2015:372796. doi: 10.1155/2015/372796. Epub 2015 May 18.

Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria.

International journal of endocrinology

Spomenka Ljubic, Anamarija Jazbec, Martina Tomic, Ante Piljac, Dubravka Jurisic Erzen, Branko Novak, Snjezana Kastelan, Marijana Vucic Lovrencic, Neva Brkljacic

Affiliations

  1. Department of Endocrinology and Metabolic Disease, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
  2. Faculty of Forestry, University of Zagreb, Svetosimunska 25, 10000 Zagreb, Croatia.
  3. Department of Ophthalmology, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
  4. Department of Internal Medicine, Rijeka University Hospital Center, Kresimirova 42, 51000 Rijeka, Croatia.
  5. Department of Diabetes, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
  6. Department of Ophthalmology, Dubrava Clinical Hospital, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
  7. Department of Laboratory Medicine, Merkur University Hospital, 10000 Zagreb, Croatia.
  8. Department of Cardiology, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.

PMID: 26089882 PMCID: PMC4451160 DOI: 10.1155/2015/372796

Abstract

Aims. To investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy. Methods. ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients. Results. Significant differences among ApN levels according to AER were found in both types of diabetes (F = 8.45, df = 2, P < 0.001). With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (F = 12.7, df = 1, P < 0.001). The best model for ApN (R (2) = 0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (R (2) = 0.2882) it included ppPG, LDL, and UA. Conclusion. ApN behaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroups with decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes.

References

  1. J Am Soc Nephrol. 2002 Jan;13(1):134-41 - PubMed
  2. J Clin Endocrinol Metab. 2007 Oct;92(10):3890-7 - PubMed
  3. Diabetes Obes Metab. 2007 May;9(3):246-58 - PubMed
  4. J Clin Endocrinol Metab. 2001 Jul;86(7):3257-65 - PubMed
  5. Nephrol Dial Transplant. 2005 Jan;20(1):129-34 - PubMed
  6. Nephrol Dial Transplant. 2008 May;23 (5):1621-7 - PubMed
  7. Nutr Metab (Lond). 2004 Oct 19;1(1):10 - PubMed
  8. Hypertension. 2004 Jun;43(6):1318-23 - PubMed
  9. Med Sci Monit. 2006 Jan;12(1):CR17-20 - PubMed
  10. Cardiovasc Res. 2010 Jun 1;86(3):471-7 - PubMed
  11. Diabetes Care. 2008 Jun;31(6):1165-9 - PubMed
  12. Circulation. 2003 Feb 11;107(5):671-4 - PubMed
  13. JAMA. 2004 Apr 14;291(14):1730-7 - PubMed
  14. Alcohol Clin Exp Res. 2003 Aug;27(8 Suppl):22S-25S - PubMed
  15. N Engl J Med. 2002 Nov 14;347(20):1557-65 - PubMed
  16. J Clin Endocrinol Metab. 2006 Jan;91(1):129-35 - PubMed
  17. Diabetes Care. 2004 Oct;27(10):2450-7 - PubMed
  18. Am J Cardiol. 2004 Apr 1;93(7):926-8 - PubMed
  19. Am J Gastroenterol. 2008 Mar;103(3):605-14 - PubMed
  20. Diabetes Res Clin Pract. 2010 May;88(2):177-83 - PubMed
  21. Circulation. 2006 Aug 15;114(7):623-9 - PubMed
  22. Diabetes Res Clin Pract. 2006 Jun;72(3):302-7 - PubMed
  23. Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):295-300 - PubMed
  24. Diabetes Care. 2004 Mar;27(3):739-45 - PubMed
  25. J Diabetes. 2015 Jan;7(1):31-40 - PubMed
  26. Med Hypotheses. 2007;69(6):1290-2 - PubMed
  27. J Am Soc Nephrol. 2006 Sep;17(9):2599-606 - PubMed
  28. Diabetes. 2002 Sep;51(9):2734-41 - PubMed
  29. BMJ. 1997 May 24;314(7093):1512-5 - PubMed
  30. Diabetes Care. 2009 Jan;32 Suppl 1:S62-7 - PubMed
  31. Clin Invest Med. 2009 Aug 01;32(4):E271-9 - PubMed
  32. Endocr J. 2007 Aug;54(4):553-8 - PubMed
  33. J Clin Invest. 2008 May;118(5):1645-56 - PubMed
  34. Diabetologia. 2005 Jun;48(6):1088-92 - PubMed
  35. J Clin Endocrinol Metab. 2004 Sep;89(9):4620-7 - PubMed
  36. J Hum Hypertens. 2008 Dec;22(12):856-63 - PubMed
  37. Eur J Endocrinol. 2003 Jun;148(6):657-62 - PubMed

Publication Types