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Huang RC, Prescott SL, Godfrey KM, et al. Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother-offspring cohort studies. J Nutr Sci. 2015;4:e12doi: 10.1017/jns.2014.69.
Huang, R. C., Prescott, S. L., Godfrey, K. M., & Davis, E. A. (2015). Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother-offspring cohort studies. Journal of nutritional science, 4e12. https://doi.org/10.1017/jns.2014.69
Huang, R-C, et al. "Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother-offspring cohort studies." Journal of nutritional science vol. 4 (2015): e12. doi: https://doi.org/10.1017/jns.2014.69
Huang RC, Prescott SL, Godfrey KM, Davis EA. Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother-offspring cohort studies. J Nutr Sci. 2015 Apr 10;4:e12. doi: 10.1017/jns.2014.69. eCollection 2015. PMID: 26090093; PMCID: PMC4463019.
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J Nutr Sci. 2015 Apr 10;4:e12. doi: 10.1017/jns.2014.69. eCollection 2015.

Assessment of cardiometabolic risk in children in population studies: underpinning developmental origins of health and disease mother-offspring cohort studies.

Journal of nutritional science

R-C Huang, Susan L Prescott, Keith M Godfrey, Elizabeth A Davis

Affiliations

  1. Telethon Kids Institute , University of Western Australia , Roberts Road , Subiaco , WA , Australia ; 'In-FLAME' the International Inflammation Network , World Universities Network (WUN) ; Department of Endocrinology , Princess Margaret Hospital , Roberts Road , Subiaco , WA , Australia.
  2. Telethon Kids Institute , University of Western Australia , Roberts Road , Subiaco , WA , Australia ; 'In-FLAME' the International Inflammation Network , World Universities Network (WUN) ; School of Paediatrics and Child Health Research , University of Western Australia , Roberts Road , Subiaco , Australia.
  3. MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre , University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton , UK.
  4. Telethon Kids Institute , University of Western Australia , Roberts Road , Subiaco , WA , Australia ; Department of Endocrinology , Princess Margaret Hospital , Roberts Road , Subiaco , WA , Australia.

PMID: 26090093 PMCID: PMC4463019 DOI: 10.1017/jns.2014.69

Abstract

Pregnancy and birth cohorts have been utilised extensively to investigate the developmental origins of health and disease, particularly in relation to understanding the aetiology of obesity and related cardiometabolic disorders. Birth and pregnancy cohorts have been utilised extensively to investigate this area of research. The aim of the present review was twofold: first to outline the necessity of measuring cardiometabolic risk in children; and second to outline how it can be assessed. The major outcomes thought to have an important developmental component are CVD, insulin resistance and related metabolic outcomes. Conditions such as the metabolic syndrome, type 2 diabetes and CHD all tend to have peak prevalence in middle-aged and older individuals but assessments of cardiometabolic risk in childhood and adolescence are important to define early causal factors and characterise preventive measures. Typically, researchers investigating prospective cohort studies have relied on the thesis that cardiovascular risk factors, such as dyslipidaemia, hypertension and obesity, track from childhood into adult life. The present review summarises some of the evidence that these factors, when measured in childhood, may be of value in assessing the risk of adult cardiometabolic disease, and as such proceeds to describe some of the methods for assessing cardiometabolic risk in children.

Keywords: Cardiovascular risk; DOHaD, developmental origins of health and disease; DXA, dual-energy X-ray absorptiometry; IMT, intima media thickness; Metabolic disease; NAFLD, non-alcoholic fatty liver disease; PWV, pulse wave velocity; Paediatric health; Population studies; TNFR, TNF receptor

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