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Syful Azlie MF, Hassan MR, Junainah S, et al. Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review. Med J Malaysia. 2015;70(1):24-30
Syful Azlie, M. F., Hassan, M. R., Junainah, S., & Rugayah, B. (2015). Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review. The Medical journal of Malaysia, 70(1), 24-30.
Syful Azlie, M F, et al. "Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review." The Medical journal of Malaysia vol. 70,1 (2015): 24-30.
Syful Azlie MF, Hassan MR, Junainah S, Rugayah B. Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review. Med J Malaysia. 2015 Feb;70(1):24-30. PMID: 26032525.
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Med J Malaysia. 2015 Feb;70(1):24-30.

Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review.

The Medical journal of Malaysia

M F Syful Azlie, M R Hassan, S Junainah, B Rugayah

Affiliations

  1. Ministry of Health Malaysia, Medical Development Division, MaHTAS, Health Technology Assessment Section, Level 4, Block E1, Complex E, Precint 1, Government Office Complex, 62590 Putrajaya, Malaysia. [email protected].
  2. Hospital Sultanah Bahiyah Kedah, Malaysia.
  3. Ministry of Health Malaysia, Medical Development Division, MaHTAS, Health Technology Assessment Section, Level 4, Block E1, Complex E, Precint 1, Government Office Complex, 62590 Putrajaya, Malaysia.

PMID: 26032525

Abstract

A systematic review on the effectiveness and costeffectiveness of Immunochemical faecal occult IFOBT for CRC screening was carried out. A total of 450 relevant titles were identified, 41 abstracts were screened and 18 articles were included in the results. There was fair level of retrievable evidence to suggest that the sensitivity and specificity of IFOBT varies with the cut-off point of haemoglobin, whereas the diagnostic accuracy performance was influenced by high temperature and haemoglobin stability. A screening programme using IFOBT can be effective for prevention of advanced CRC and reduced mortality. There was also evidence to suggest that IFOBT is cost-effective in comparison with no screening, whereby a two-day faecal collection method was found to be costeffective as a means of screening for CRC. Based on the review, quantitative IFOBT method can be used in Malaysia as a screening test for CRC. The use of fully automated IFOBT assay would be highly desirable.

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