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Miyachi M, Matsuno T, Asano K, et al. Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1. J Clin Biochem Nutr. 2015;56(3):171-8doi: 10.3164/jcbn.14-109.
Miyachi, M., Matsuno, T., Asano, K., & Mataga, I. (2015). Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1. Journal of clinical biochemistry and nutrition, 56(3), 171-8. https://doi.org/10.3164/jcbn.14-109
Miyachi, Masashiro, et al. "Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1." Journal of clinical biochemistry and nutrition vol. 56,3 (2015): 171-8. doi: https://doi.org/10.3164/jcbn.14-109
Miyachi M, Matsuno T, Asano K, Mataga I. Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1. J Clin Biochem Nutr. 2015 May;56(3):171-8. doi: 10.3164/jcbn.14-109. Epub 2015 Jan 29. PMID: 26060346; PMCID: PMC4454080.
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J Clin Biochem Nutr. 2015 May;56(3):171-8. doi: 10.3164/jcbn.14-109. Epub 2015 Jan 29.

Anti-inflammatory effects of astaxanthin in the human gingival keratinocyte line NDUSD-1.

Journal of clinical biochemistry and nutrition

Masashiro Miyachi, Tomonori Matsuno, Kazunari Asano, Izumi Mataga

Affiliations

  1. Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan.

PMID: 26060346 PMCID: PMC4454080 DOI: 10.3164/jcbn.14-109

Abstract

Oral lichen planus is a chronic inflammatory disease that affects the mucous membrane of the oral cavity and can contribute to the development of other diseases. Inflammation in oral lichen planus is a T-cell-mediated autoimmune disease that acts through cytotoxic CD8(+) T cells to trigger apoptosis of keratinocytes. However, the specific cause of oral lichen planus remains unknown and no effective medical treatment has yet been established. Astaxanthin is a carotenoid pigment with capacity for anti-inflammatory and anti-oxidant activities. In this study, we evaluated whether astaxanthin could be used to improve the pathology of oral lichen planus by reducing inflammation. In particular, the anti-inflammatory effects of astaxanthin on the chronic inflammation caused by lipopolysaccharide derived from Escherichia coli O55 in human gingival keratinocytes (NDUSD-1) were evaluated. Following astaxanthin treatment, localization of nuclear factor κB/p65 and the level of inflammatory cytokines (interleukin-6, tumor necrosis factor-α) tended to decrease, and cell proliferation significantly increased in vitro. These results suggest that astaxanthin could be useful for improving chronic inflammation such as that associated with oral lichen planus.

Keywords: astaxanthin; chronic inflammation; human gingival keratinocyte; inflammatory cytokine; nuclear factor κB/p65

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