Display options
Cite
Dharma S, Hapsari R, Siswanto BB, et al. Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. Int J Angiol. 2015;24(2):127-32doi: 10.1055/s-0035-1544178.
Dharma, S., Hapsari, R., Siswanto, B. B., van der Laarse, A., & Jukema, J. W. (2015). Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. The International journal of angiology : official publication of the International College of Angiology, Inc, 24(2), 127-32. https://doi.org/10.1055/s-0035-1544178
Dharma, Surya, et al. "Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction." The International journal of angiology : official publication of the International College of Angiology, Inc vol. 24,2 (2015): 127-32. doi: https://doi.org/10.1055/s-0035-1544178
Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW. Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. Int J Angiol. 2015 Jun;24(2):127-32. doi: 10.1055/s-0035-1544178. PMID: 26060384; PMCID: PMC4452600.
Copy Download .nbib Format: NLM
Share it on

Int J Angiol. 2015 Jun;24(2):127-32. doi: 10.1055/s-0035-1544178.

Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction.

The International journal of angiology : official publication of the International College of Angiology, Inc

Surya Dharma, Rosmarini Hapsari, Bambang B Siswanto, Arnoud van der Laarse, J Wouter Jukema

Affiliations

  1. Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
  2. Department of Cardiology and Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  3. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

PMID: 26060384 PMCID: PMC4452600 DOI: 10.1055/s-0035-1544178

Abstract

We aim to test the hypothesis that blood leukocyte count adds prognostic information in patients with acute non-ST-elevation myocardial infarction (non-STEMI). A total of 585 patients with acute non-STEMI (thrombolysis in myocardial infarction risk score ≥ 3) were enrolled in this cohort retrospective study. Blood leukocyte count was measured immediately after admission in the emergency department. The composite of death, reinfarction, urgent revascularization, and stroke during hospitalization were defined as the primary end point of the study. The mean age of the patients was 61 ± 9.6 years and most of them were male (79%). Using multivariate Cox regression analysis involving seven variables (history of smoking, hypertension, heart rate > 100 beats/minute, serum creatinine level > 1.5 mg/dL, blood leukocyte count > 11,000/µL, use of β-blocker, and use of angiotensin-converting enzyme inhibitor), leukocyte count > 11,000/µL demonstrated to be a strong predictor of the primary end point (hazard ratio = 3.028; 95% confidence interval = 1.69-5.40, p < 0.001). The high blood leukocyte count on admission is an independent predictor of cardiovascular events in patients with acute non-STEMI.

Keywords: acute non-STEMI; cardiovascular event; leukocyte count; predictor

References

  1. Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3399-405 - PubMed
  2. Am J Cardiol. 2001 Mar 1;87(5):636-9, A10 - PubMed
  3. J Clin Epidemiol. 2001 Mar;54(3):316-22 - PubMed
  4. J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38 - PubMed
  5. JAMA. 2000 Aug 16;284(7):835-42 - PubMed
  6. Curr Opin Crit Care. 2006 Oct;12(5):412-9 - PubMed
  7. Heart. 2003 Apr;89(4):389-92 - PubMed
  8. Am J Epidemiol. 2001 Oct 15;154(8):758-64 - PubMed
  9. J Am Coll Cardiol. 2004 Nov 16;44(10):1945-56 - PubMed
  10. Circulation. 2004 Mar 23;109(11):1343-8 - PubMed
  11. Jpn Heart J. 2003 Mar;44(2):201-11 - PubMed
  12. Am J Epidemiol. 1996 Jun 1;143(11):1107-15 - PubMed
  13. J Am Coll Cardiol. 2001 Nov 15;38(6):1654-61 - PubMed
  14. BMC Med Genet. 2004 Jun 01;5:13 - PubMed
  15. Haemostasis. 1999 Sep;29(1):41-9 - PubMed
  16. J Cardiovasc Pharmacol. 1998;32 Suppl 3:S62-6 - PubMed
  17. Circulation. 1995 Jun 1;91(11):2844-50 - PubMed
  18. Arch Intern Med. 2003 Oct 27;163(19):2345-53 - PubMed
  19. Neth Heart J. 2012 Jun;20(6):254-9 - PubMed

Publication Types