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Nurnberg ST, Cheng K, Raiesdana A, et al. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap. Genom Data. 2015;5:36-37doi: 10.1016/j.gdata.2015.05.007.
Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., Arora, K., Carcamo-Oribe, I., Xiong, Y., Tellakula, N., Nanda, V., Murthy, N., Boisvert, W. A., Hedin, U., Perisic, L., Aldi, S., Maegdefessel, L., Pjanic, M., Owens, G. K., Tallquist, M. D., & Quertermous, T. (2015). Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap. Genomics data, 536-37. https://doi.org/10.1016/j.gdata.2015.05.007
Nurnberg, S T, et al. "Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap." Genomics data vol. 5 (2015): 36-37. doi: https://doi.org/10.1016/j.gdata.2015.05.007
Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap. Genom Data. 2015 Sep 01;5:36-37. doi: 10.1016/j.gdata.2015.05.007. PMID: 26090325; PMCID: PMC4467834.
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Genom Data. 2015 Sep 01;5:36-37. doi: 10.1016/j.gdata.2015.05.007.

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap.

Genomics data

S T Nurnberg, K Cheng, A Raiesdana, R Kundu, C L Miller, J B Kim, K Arora, I Carcamo-Oribe, Y Xiong, N Tellakula, V Nanda, N Murthy, W A Boisvert, U Hedin, L Perisic, S Aldi, L Maegdefessel, M Pjanic, G K Owens, M D Tallquist, T Quertermous

Affiliations

  1. Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
  2. Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii 96813.
  3. Departments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, Sweden.
  4. Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908.

PMID: 26090325 PMCID: PMC4467834 DOI: 10.1016/j.gdata.2015.05.007

Abstract

TCF21 is a basic helix-loop-helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461).

References

  1. Genome Biol. 2009;10(3):R25 - PubMed
  2. Bioinformatics. 2009 May 1;25(9):1105-11 - PubMed
  3. Bioinformatics. 2010 Jan 1;26(1):139-40 - PubMed
  4. Genome Biol. 2010;11(10):R106 - PubMed

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