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De Toro J, Herschlik L, Waldner C, et al. Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications. Front Immunol. 2015;6:203doi: 10.3389/fimmu.2015.00203.
De Toro, J., Herschlik, L., Waldner, C., & Mongini, C. (2015). Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications. Frontiers in immunology, 6203. https://doi.org/10.3389/fimmu.2015.00203
De Toro, Julieta, et al. "Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications." Frontiers in immunology vol. 6 (2015): 203. doi: https://doi.org/10.3389/fimmu.2015.00203
De Toro J, Herschlik L, Waldner C, Mongini C. Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications. Front Immunol. 2015 May 04;6:203. doi: 10.3389/fimmu.2015.00203. eCollection 2015. PMID: 25999947; PMCID: PMC4418172.
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Front Immunol. 2015 May 04;6:203. doi: 10.3389/fimmu.2015.00203. eCollection 2015.

Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications.

Frontiers in immunology

Julieta De Toro, Leticia Herschlik, Claudia Waldner, Claudia Mongini

Affiliations

  1. Centro de Estudios Farmacológicos y Botánicos (CEFyBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires , Buenos Aires , Argentina.

PMID: 25999947 PMCID: PMC4418172 DOI: 10.3389/fimmu.2015.00203

Abstract

From the time when they were first described in the 1970s by the group of Johnstone and Stahl, exosomes are a target of constant research. Exosomes belong to the family of nanovesicles which are of great interest for their many functions and potential for diagnosis and therapy in multiples diseases. Exosomes originate from the intraluminal vesicles of late endosomal compartments named multivesicular bodies and the fusion of these late endosomes with the cell membrane result in the release of the vesicles into the extracellular compartment. Moreover, their generation can be induced by many factors including extracellular stimuli, such as microbial attack and other stress conditions. The primary role attributed to exosomes was the removal of unnecessary proteins from the cells. Now, several studies have demonstrated that exosomes are involved in cell-cell communication, even though their biological function is not completely clear. The participation of exosomes in cancer is the field of microvesicle research that has expanded more over the last years. Evidence proving that exosomes derived from tumor-pulsed dendritic cells, neoplastic cells, and malignant effusions are able to present antigens to T-cells, has led to numerous studies using them as cell-free cancer vaccines. Because exosomes derive from all cell types, they contain proteins, lipids, and micro RNA capable of regulating a variety of target genes. Much research is being conducted, which focuses on the employment of these vesicles as biomarkers in the diagnosis of cancer in addition to innovative biomarkers for diagnosis, prognosis, and management of cardiovascular diseases. Interesting findings indicating the role of exosomes in the pathogenesis of several diseases have encouraged researchers to consider their therapeutic potential not only in oncology but also in the treatment of autoimmune syndromes and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, in addition to infectious diseases such as tuberculosis, diphtheria, and toxoplasmosis as well as infections caused by prions or viruses such as HIV. The aim of this review is to disclose the emerging roles of exosomes in normal and pathological conditions and to discuss their potential therapeutic applications.

Keywords: biomarkers; cancer; exosomes; infectious disease therapy; neurodegenerative disorders; pharmacological; therapeutics

References

  1. Am J Reprod Immunol. 2014 Nov;72(5):440-57 - PubMed
  2. PLoS One. 2008 Jun 18;3(6):e2461 - PubMed
  3. BMC Cancer. 2009 Jul 20;9:244 - PubMed
  4. J Biol Chem. 2014 Aug 8;289(32):22284-305 - PubMed
  5. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):738-43 - PubMed
  6. Nat Med. 1998 May;4(5):594-600 - PubMed
  7. Adv Drug Deliv Rev. 2013 Mar;65(3):376-82 - PubMed
  8. J Biol Chem. 2012 May 4;287(19):15874-85 - PubMed
  9. J Control Release. 2015 Feb 10;199:145-55 - PubMed
  10. Stem Cell Res. 2010 May;4(3):214-22 - PubMed
  11. J Biol Chem. 1987 Jul 5;262(19):9412-20 - PubMed
  12. J Biotechnol. 2013 May 20;165(2):77-84 - PubMed
  13. Traffic. 2008 Jun;9(6):871-81 - PubMed
  14. Am J Reprod Immunol. 2007 Nov;58(5):389-402 - PubMed
  15. J Immunol. 2009 Feb 1;182(3):1548-59 - PubMed
  16. Blood. 2004 Nov 15;104(10):3257-66 - PubMed
  17. PLoS One. 2014 Jul 31;9(7):e103811 - PubMed
  18. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2925-33 - PubMed
  19. Front Cell Neurosci. 2013 Oct 30;7:182 - PubMed
  20. PLoS Pathog. 2014 Oct 02;10(10):e1004424 - PubMed
  21. FASEB J. 2012 Oct;26(10):4160-73 - PubMed
  22. Traffic. 2010 Jan;11(1):110-22 - PubMed
  23. PLoS One. 2009;4(4):e5219 - PubMed
  24. Cell Host Microbe. 2012 Oct 18;12(4):558-70 - PubMed
  25. J Allergy Clin Immunol. 2007 Dec;120(6):1418-24 - PubMed
  26. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7 - PubMed
  27. Genes Dev. 2005 Nov 15;19(22):2645-55 - PubMed
  28. J Extracell Vesicles. 2012 Apr 16;1:null - PubMed
  29. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9683-8 - PubMed
  30. Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22 - PubMed
  31. J Immunol Methods. 2002 Dec 15;270(2):211-26 - PubMed
  32. Curr Oncol. 2009 May;16(3):46-9 - PubMed
  33. Nat Med. 2012 Jun;18(6):883-91 - PubMed
  34. Cell Mol Life Sci. 2015 Mar;72(6):1185-96 - PubMed
  35. Cancer Res. 2005 Jun 15;65(12):5238-47 - PubMed
  36. J Transl Med. 2012 Jan 05;10:5 - PubMed
  37. Nat Med. 2001 Mar;7(3):297-303 - PubMed
  38. J Extracell Vesicles. 2013 Feb 15;2:null - PubMed
  39. J Immunol. 2010 Jan 1;184(1):236-43 - PubMed
  40. J Transl Med. 2011 Jan 14;9:9 - PubMed
  41. Immunol Lett. 2006 Nov 15;107(2):102-8 - PubMed
  42. Retrovirology. 2014 Nov 19;11:102 - PubMed
  43. J Immunol. 2003 Mar 15;170(6):3037-45 - PubMed
  44. Nat Rev Drug Discov. 2013 May;12(5):347-57 - PubMed
  45. J Transl Med. 2005 Feb 21;3(1):9 - PubMed
  46. J Proteomics. 2014 Jan 31;97:177-86 - PubMed
  47. Circ Res. 2014 Jan 17;114(2):325-32 - PubMed
  48. Mol Cell Neurosci. 2011 Feb;46(2):409-18 - PubMed
  49. PLoS One. 2012;7(9):e45974 - PubMed
  50. Am J Transplant. 2006 Jul;6(7):1541-50 - PubMed
  51. PLoS One. 2014 Jun 06;9(6):e98667 - PubMed
  52. Cancer Res. 2007 Aug 1;67(15):7458-66 - PubMed
  53. Biomed Res Int. 2014;2014:693157 - PubMed
  54. Am J Reprod Immunol. 2010 Jun;63(6):520-33 - PubMed
  55. Ann Oncol. 2004;15 Suppl 4:iv141-4 - PubMed
  56. Am J Pathol. 2007 Dec;171(6):2012-20 - PubMed
  57. Blood. 2012 Jan 19;119(3):756-66 - PubMed
  58. PLoS One. 2011;6(10):e26588 - PubMed
  59. Kidney Int. 2010 Oct;78(8):810-6 - PubMed
  60. Br J Cancer. 2005 Jan 31;92 (2):305-11 - PubMed
  61. J Exp Med. 1996 Mar 1;183(3):1161-72 - PubMed
  62. Lancet. 2002 Jul 27;360(9329):295-305 - PubMed
  63. Eur J Immunol. 2006 Jul;36(7):1772-81 - PubMed
  64. Methods Mol Biol. 2007;380:443-55 - PubMed
  65. Cell Death Dis. 2012 Aug 30;3:e381 - PubMed
  66. J Biol Chem. 2003 Dec 26;278(52):52347-54 - PubMed
  67. J Immunol. 2006 Sep 15;177(6):3757-62 - PubMed
  68. J Pathol. 2007 Apr;211(5):582-90 - PubMed
  69. Proteomics. 2009 Nov;9(21):4997-5000 - PubMed
  70. Nat Rev Immunol. 2002 Aug;2(8):569-79 - PubMed
  71. Hum Mol Genet. 2012 Oct 15;21(R1):R125-34 - PubMed
  72. J Biol Chem. 2005 Jun 17;280(24):23349-55 - PubMed
  73. Neoplasia. 2013 Mar;15(3):281-95 - PubMed
  74. J Immunol. 2007 Aug 1;179(3):1913-25 - PubMed
  75. Br J Cancer. 2009 May 19;100(10):1603-7 - PubMed
  76. Med Hypotheses. 2008;70(6):1226-7 - PubMed
  77. Clin Chem. 2011 Jan;57(1):18-32 - PubMed
  78. J Cereb Blood Flow Metab. 2013 Nov;33(11):1711-5 - PubMed
  79. J Immunol. 2008 Mar 15;180(6):4299-307 - PubMed
  80. Cell. 2013 May 23;153(5):1120-33 - PubMed
  81. Kidney Int. 2006 Nov;70(10):1847-57 - PubMed
  82. Leukemia. 2014 Apr;28(4):970-3 - PubMed
  83. Biochem Pharmacol. 2012 Jun 1;83(11):1484-94 - PubMed
  84. J Immunol. 2007 Aug 15;179(4):2242-9 - PubMed
  85. Mol Ther. 2013 Jan;21(1):185-91 - PubMed
  86. J Neurosurg. 2015 Apr;122(4):856-67 - PubMed
  87. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7 - PubMed
  88. Nat Biotechnol. 2011 Apr;29(4):341-5 - PubMed
  89. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10592-7 - PubMed
  90. Tuberculosis (Edinb). 2015 Jan;95(1):26-30 - PubMed
  91. J Biol Chem. 2014 Oct 17;289(42):29247-60 - PubMed
  92. PLoS One. 2010 Jul 22;5(7):e11469 - PubMed
  93. PLoS One. 2012;7(8):e44045 - PubMed
  94. Mol Neurodegener. 2012 Aug 24;7:42 - PubMed
  95. Blood. 2009 Feb 26;113(9):1957-66 - PubMed
  96. Am J Physiol Renal Physiol. 2009 Oct;297(4):F1006-16 - PubMed
  97. PLoS One. 2012;7(4):e34653 - PubMed
  98. Cancer Immunol Immunother. 2004 Mar;53(3):234-9 - PubMed
  99. Semin Thromb Hemost. 2010 Nov;36(8):907-16 - PubMed
  100. J Immunol. 2012 Sep 15;189(6):2833-42 - PubMed
  101. Infect Immun. 2007 Jan;75(1):220-30 - PubMed
  102. Nat Rev Immunol. 2009 Aug;9(8):581-93 - PubMed
  103. Biochim Biophys Acta. 2012 Jul;1820(7):940-8 - PubMed
  104. Biochem Biophys Res Commun. 2013 Feb 15;431(3):566-71 - PubMed
  105. PLoS Biol. 2013 Jul;11(7):e1001604 - PubMed
  106. Proteomics. 2013 May;13(10-11):1572-80 - PubMed
  107. Cell Microbiol. 2011 Jan;13(1):1-9 - PubMed
  108. Nat Cell Biol. 2008 Dec;10(12):1470-6 - PubMed
  109. Arch Neurol. 2009 Mar;66(3):382-9 - PubMed
  110. J Control Release. 2012 Jul 20;161(2):175-87 - PubMed
  111. Front Immunol. 2014 Oct 22;5:518 - PubMed
  112. Placenta. 2012 Feb;33 Suppl:S48-54 - PubMed
  113. J Biol Chem. 2013 Jul 5;288(27):20014-33 - PubMed
  114. Curr Opin Cell Biol. 2009 Aug;21(4):575-81 - PubMed
  115. Int J Biochem Cell Biol. 2012 Sep;44(9):1574-84 - PubMed
  116. Mol Ther. 2006 Feb;13(2):289-300 - PubMed
  117. PLoS One. 2013;8(1):e48814 - PubMed
  118. J Mol Med (Berl). 2007 May;85(5):511-21 - PubMed
  119. J Mol Med (Berl). 2006 Dec;84(12):1067-76 - PubMed
  120. Annu Rev Cell Dev Biol. 2014;30:255-89 - PubMed
  121. Science. 2001 Aug 24;293(5534):1491-5 - PubMed
  122. PLoS Pathog. 2010 Mar 26;6(3):e1000740 - PubMed
  123. Nat Immunol. 2002 Dec;3(12):1156-62 - PubMed
  124. J Transl Med. 2005 Mar 02;3(1):10 - PubMed
  125. Nat Rev Immunol. 2014 Mar;14(3):195-208 - PubMed
  126. J Immunol Methods. 2008 Jun 1;335(1-2):98-105 - PubMed
  127. Am J Reprod Immunol. 2006 Nov-Dec;56(5-6):345-55 - PubMed
  128. Cell Commun Signal. 2013 Nov 18;11:88 - PubMed
  129. J Exp Med. 2002 May 20;195(10):1303-16 - PubMed
  130. Mol Ther. 2008 Apr;16(4):782-90 - PubMed
  131. Front Immunol. 2014 Aug 20;5:403 - PubMed
  132. Microbes Infect. 2007 Nov-Dec;9(14-15):1614-22 - PubMed
  133. J Mol Cell Cardiol. 2012 Dec;53(6):848-57 - PubMed
  134. Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94 - PubMed
  135. Vaccine. 2006 Mar 20;24(13):2264-74 - PubMed
  136. Cancer Res. 2010 Dec 1;70(23):9621-30 - PubMed
  137. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33 - PubMed
  138. Cancer Gene Ther. 2014 Apr;21(4):139-41 - PubMed
  139. J Immunol. 2005 May 15;174(10):6440-8 - PubMed

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