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Espinosa G, Cervera R. Management of the antiphospholipid syndrome. Auto Immun Highlights. 2010;1(1):15-22doi: 10.1007/s13317-010-0004-6.
Espinosa, G., & Cervera, R. (2010). Management of the antiphospholipid syndrome. Auto- immunity highlights, 1(1), 15-22. https://doi.org/10.1007/s13317-010-0004-6
Espinosa, Gerard, and Cervera, Ricard. "Management of the antiphospholipid syndrome." Auto- immunity highlights vol. 1,1 (2010): 15-22. doi: https://doi.org/10.1007/s13317-010-0004-6
Espinosa G, Cervera R. Management of the antiphospholipid syndrome. Auto Immun Highlights. 2010 Jul 10;1(1):15-22. doi: 10.1007/s13317-010-0004-6. eCollection 2010 May. PMID: 26000103; PMCID: PMC4389060.
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Auto Immun Highlights. 2010 Jul 10;1(1):15-22. doi: 10.1007/s13317-010-0004-6. eCollection 2010 May.

Management of the antiphospholipid syndrome.

Auto- immunity highlights

Gerard Espinosa, Ricard Cervera

Affiliations

  1. Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Villarroel 170, 08036 Barcelona, Catalonia, Spain.

PMID: 26000103 PMCID: PMC4389060 DOI: 10.1007/s13317-010-0004-6

Abstract

Antiphospholipid syndrome (APS) is characterized by recurrent venous or arterial thromboses, fetal losses and thrombocytopenia in the presence of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies or antibodies directed to various proteins, mainly β2 glycoprotein I, or all three. There is consensus in treating patients with APS and first venous thrombosis with oral anticoagulation to a target international normalized ratio (INR) of 2.0-3.0. A recent systematic review recommended a target INR of >3.0 in those patients with APS and arterial thrombosis. The approach in women with obstetric manifestations of APS is based on the use of aspirin plus heparin. The best treatment for patients with the catastrophic variant of the APS is a combination of anticoagulation, corticosteroids, and plasma exchange or intravenous immunoglobulins.

Keywords: Antiphospholipid antibodies; Antiphospholipid syndrome; Therapy

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