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Morozzi G, Bellisai F, Fineschi I, et al. Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients. Auto Immun Highlights. 2011;2(1):29-33doi: 10.1007/s13317-011-0015-y.
Morozzi, G., Bellisai, F., Fineschi, I., Scaccia, F., Pucci, G., Simpatico, A., Tampoia, M., Chialà, A., Lapadula, G., & Galeazzi, M. (2011). Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients. Auto- immunity highlights, 2(1), 29-33. https://doi.org/10.1007/s13317-011-0015-y
Morozzi, Gabriella, et al. "Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients." Auto- immunity highlights vol. 2,1 (2011): 29-33. doi: https://doi.org/10.1007/s13317-011-0015-y
Morozzi G, Bellisai F, Fineschi I, Scaccia F, Pucci G, Simpatico A, Tampoia M, Chialà A, Lapadula G, Galeazzi M. Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients. Auto Immun Highlights. 2011 Mar 23;2(1):29-33. doi: 10.1007/s13317-011-0015-y. eCollection 2011 May. PMID: 26000117; PMCID: PMC4389072.
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Auto Immun Highlights. 2011 Mar 23;2(1):29-33. doi: 10.1007/s13317-011-0015-y. eCollection 2011 May.

Prevalence of anti-histone antibodies, their clinical significance and correlation with other autoantibodies in a cohort of Italian scleroderma patients.

Auto- immunity highlights

Gabriella Morozzi, Francesca Bellisai, Irene Fineschi, Francesca Scaccia, Gabriella Pucci, Antonella Simpatico, Marilina Tampoia, Alessandra Chialà, Giovanni Lapadula, Mauro Galeazzi

Affiliations

  1. Sezione di Reumatologia, Dipartimento di Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy.
  2. Patologia Clinica I, Ospedale Policlinico-Bari, Bari, Italy.
  3. Sezione di Reumatologia, Dipartimento di Medicina Interna e Medicina Pubblica (DiMIMP), Bari, Italy.

PMID: 26000117 PMCID: PMC4389072 DOI: 10.1007/s13317-011-0015-y

Abstract

PURPOSE: The aim of our study was to determine the prevalence, clinical significance of antibodies to individual histone components and to evaluate their correlation with other autoantibody specificities in a cohort of Italian SSc patients. Some authors, demonstrated high prevalence of anti-histone antibodies in Italian SSc patients, associated with cardiac and renal involvement, suggesting a prognostic value of these autoantibodies; however, these data need to be confirmed.

METHODS: Serum from 112 adult SSc patients, classified as diffuse (dc) and limited cutaneous (lc) SSc subsets were analyzed for autoantibodies by indirect immunofluorescence, fluoroenzyme immunoassay and enzyme immunoassay.

RESULTS: AHA were found in 13 patients (11.6%), nine with lcSSc and four with dcSSc. Among them, five patients were anti-Scl70+ and four were anti-CENP B+. The presence of AHA was not associated with multi-organ involvement or with diffuse subset, as already described. Anti-Scl70 was detected in 43% of patients, anti-CENP B in 32% and anti-RNA polymerase III in 7.1%. We confirmed the association between anti-Scl70 antibodies and pulmonary fibrosis (OR 15.75, p < 0.0001).

CONCLUSION: In our experience, the very low prevalence of AHA in Italian SSc patients and the lack of association with clinical manifestations suggest that this test is of little clinical use; however, it would be worthwhile extending the study to a larger population of patients.

Keywords: Anti-histone antibodies; Clinical manifestations; Prevalence; Systemic sclerosis

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