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Brown PD, Blanchard M, Jethwa K, et al. The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study. Neurooncol Pract. 2014;1(1):22-28doi: 10.1093/nop/npt001.
Brown, P. D., Blanchard, M., Jethwa, K., Flemming, K. D., Brown, C. A., Kline, R. W., Jacobson, D. J., St Sauver, J., Pollock, B. E., Garces, Y. I., Stafford, S. L., Link, M. J., Erickson, D., Foote, R. L., & Laack, N. N. (2014). The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study. Neuro-oncology practice, 1(1), 22-28. https://doi.org/10.1093/nop/npt001
Brown, Paul D, et al. "The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study." Neuro-oncology practice vol. 1,1 (2014): 22-28. doi: https://doi.org/10.1093/nop/npt001
Brown PD, Blanchard M, Jethwa K, Flemming KD, Brown CA, Kline RW, Jacobson DJ, St Sauver J, Pollock BE, Garces YI, Stafford SL, Link MJ, Erickson D, Foote RL, Laack NN. The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study. Neurooncol Pract. 2014 Mar;1(1):22-28. doi: 10.1093/nop/npt001. PMID: 26034611; PMCID: PMC4369699.
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Neurooncol Pract. 2014 Mar;1(1):22-28. doi: 10.1093/nop/npt001.

The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study.

Neuro-oncology practice

Paul D Brown, Miran Blanchard, Krishan Jethwa, Kelly D Flemming, Cerise A Brown, Robert W Kline, Debra J Jacobson, Jennifer St Sauver, Bruce E Pollock, Yolanda I Garces, Scott L Stafford, Michael J Link, Dana Erickson, Robert L Foote, Nadia N I Laack

Affiliations

  1. Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

PMID: 26034611 PMCID: PMC4369699 DOI: 10.1093/nop/npt001

Abstract

BACKGROUND: To assess the risk of cerebrovascular accidents (CVAs) and second brain tumors (SBTs) in patients with pituitary adenoma after surgery or radiotherapy.

METHODS: A cohort of 143 people from Olmsted County, who were diagnosed with pituitary adenoma between 1933 and 2000, was studied. Only patients from Olmsted County were included because of the unique nature of medical care in Olmsted County, which allows the ascertainment of virtually all cases of pituitary adenoma for this community's residents and comparisons to the general population in the county. Surgical resection was performed in 76 patients, 29 patients underwent radiotherapy (with 21 undergoing both surgery and radiotherapy), 5 patients were reirradiated, and 59 patients were managed conservatively and observed.

RESULTS: Median follow-up was 15.5 years. There was no difference in CVA-free survival between treatment groups. On univariate analysis age > 60 years (hazard ratio [HR], 11.93; 95% CI, 6.26-23.03;

CONCLUSION: CVA is a significant risk for patients with pituitary tumors, but treatment does not seem to impact the risk. Even with long-term follow-up, SBTs are a rare event regardless of treatment modality.

Keywords: pituitary adenoma; radiotherapy; secondary malignancy; stroke; surgery

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