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Kulkarni C, Chaudhuri UR, Jagathesan A. Bilateral acute angle-closure glaucoma following treatment with topiramate for headache. Neurol Ther. 2013;2(1):57-62doi: 10.1007/s40120-013-0008-z.
Kulkarni, C., Chaudhuri, U. R., & Jagathesan, A. (2013). Bilateral acute angle-closure glaucoma following treatment with topiramate for headache. Neurology and therapy, 2(1), 57-62. https://doi.org/10.1007/s40120-013-0008-z
Kulkarni, Chanda, et al. "Bilateral acute angle-closure glaucoma following treatment with topiramate for headache." Neurology and therapy vol. 2,1 (2013): 57-62. doi: https://doi.org/10.1007/s40120-013-0008-z
Kulkarni C, Chaudhuri UR, Jagathesan A. Bilateral acute angle-closure glaucoma following treatment with topiramate for headache. Neurol Ther. 2013 Mar 26;2(1):57-62. doi: 10.1007/s40120-013-0008-z. eCollection 2013 Dec. PMID: 26000216; PMCID: PMC4389031.
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Neurol Ther. 2013 Mar 26;2(1):57-62. doi: 10.1007/s40120-013-0008-z. eCollection 2013 Dec.

Bilateral acute angle-closure glaucoma following treatment with topiramate for headache.

Neurology and therapy

Chanda Kulkarni, Urmimala Ray Chaudhuri, Annalakshmi Jagathesan

Affiliations

  1. Division of Clinical Pharmacology, St. John's Medical College, Bangalore, India.
  2. Dayananda Sagar College of Dental Sciences, Kumaraswamy Layout, Bangalore, Karnataka India ; University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX USA.

PMID: 26000216 PMCID: PMC4389031 DOI: 10.1007/s40120-013-0008-z

Abstract

INTRODUCTION: This case report adds supportive evidence to the development of acute angle-closure glaucoma (AACG), a rare but serious adverse effect following the use of topiramate (TPM) for a severe headache.

CASE REPORT: A 25-year-old female reported with severe headache, suspected to be migraine, and was started on TPM 25 mg/day on the first day. However, she presented at the emergency clinic of a hospital with sudden blurring of vision and colored halos 5 days after stopping the drug, i.e., day 8. She was subjected to ophthalmic examination and was diagnosed with AACG. The intraocular pressure (IOP) was found to be elevated and she was hence started on acetazolamide 500 mg instantly, maintained on tablet acetazolamide 250 mg four times a day (QID), pilocarpine 2% eye drops QID, travoprost 0.004% once a day (OD), and dorzolamide 2% eye drops three times a day (TID). After a week's treatment, there was rapid improvement with return of IOP to normal.

CONCLUSION: TPM-induced AACG is a rare serious adverse event leading to blindness but is preventable, when diagnosed early and by instituting appropriate treatment.

Keywords: Acute angle-closure glaucoma; Headache; Intraocular pressure; Neurology; Ophthalmology; Topiramate

References

  1. Ophthalmology. 2004 Jul;111(7):1275-9 - PubMed
  2. Indian J Ophthalmol. 2010 May-Jun;58(3):248-52 - PubMed
  3. Ann Gen Psychiatry. 2005 Feb 16;4(1):5 - PubMed
  4. J Med Case Rep. 2011 Jan 26;5:33 - PubMed
  5. Indian J Psychiatry. 2011 Apr;53(2):163-5 - PubMed
  6. Br J Ophthalmol. 2003 May;87(5):648-9 - PubMed
  7. Hong Kong Med J. 2012 Apr;18(2):139-45 - PubMed
  8. Cases J. 2009 Jul 03;2:7430 - PubMed
  9. Am Fam Physician. 2006 Jan 1;73(1):72-8 - PubMed
  10. Indian J Ophthalmol. 1998 Jun;46(2):81-6 - PubMed
  11. J Postgrad Med. 2006 Jan-Mar;52(1):72-3 - PubMed
  12. Cases J. 2009 Jan 26;2(1):87 - PubMed
  13. Curr Opin Ophthalmol. 2002 Apr;13(2):55-60 - PubMed
  14. Clin Ther. 1997 Nov-Dec;19(6):1294-308 - PubMed
  15. Ophthalmology. 2004 Jan;111(1):109-11 - PubMed
  16. J Ocul Pharmacol Ther. 2012 Apr;28(2):205-7 - PubMed

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